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The map label for this gene is hisH [H]

Identifier: 126699155

GI number: 126699155

Start: 1799057

End: 1799662

Strand: Direct

Name: hisH [H]

Synonym: CD1551

Alternate gene names: 126699155

Gene position: 1799057-1799662 (Clockwise)

Preceding gene: 126699154

Following gene: 126699156

Centisome position: 41.93

GC content: 29.37

Gene sequence:

>606_bases
ATGAATATAATAGTAGACTATGGTCTTGGAAATATAGATTCTGTGTCTAGGGGTTTTAGAAAAGCTGGAATAGAAACTAA
AATTTCTAGTGATATAGATGAAATAAAACAGGCAGATTCACTTATACTTCCGGGTGTTGGAGCTTTTAGAGATTCTATAA
GTGCCTTAGATAAACTAGGATTGATACCAATAATAAAGGAGCATGTTTCTAAGGGTAAATTTATGATAGGTATATGTCTA
GGAATGCAATTACTTTATGAAAAAAGTTATGAGTATGGAGAATATGAAGGATTAGGACTTATAAAAGGAAGTATTGATAA
ACTGGATATAAGTTTAAAAGTGCCACATATGGGATGGAATAATCTAAAATTTAATAAGGCAAATGATGATATACTTAAAT
ATATAAATGAAGATGATTATGTATACTTCGTTCACTCATATTATGCAAATTCATCAAATGAAGAACTAATTGCATTTTCA
GAATATGAAAAGAAAATCCCTGCTATTGTTAGAAAAGGCAATGTATATGGTATACAATTTCATCCTGAAAAAAGTGGAGA
AGTAGGGTTAAATATATTAAGAGCATATGGGGAGATGATAAAATGA

Upstream 100 bases:

>100_bases
CATAAGATAGAAAGTATTTTTAAAGCATTTGCAAGAGCTTTAAAAGAGGGTAGTGAAATAGTTTCTAATGAGATAGCATC
TTCAAAGGGGGTTTTGTAGA

Downstream 100 bases:

>100_bases
TAATATTTCCAGCAATAGATATAAAAGATAATAAGTGTGTAAGACTCACACAAGGAGAATTTGACAAAGTAAATGTATAT
TATGATAATCCATTAGAAGT

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILPGVGAFRDSISALDKLGLIPIIKEHVSKGKFMIGICL
GMQLLYEKSYEYGEYEGLGLIKGSIDKLDISLKVPHMGWNNLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFS
EYEKKIPAIVRKGNVYGIQFHPEKSGEVGLNILRAYGEMIK

Sequences:

>Translated_201_residues
MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILPGVGAFRDSISALDKLGLIPIIKEHVSKGKFMIGICL
GMQLLYEKSYEYGEYEGLGLIKGSIDKLDISLKVPHMGWNNLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFS
EYEKKIPAIVRKGNVYGIQFHPEKSGEVGLNILRAYGEMIK
>Mature_201_residues
MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILPGVGAFRDSISALDKLGLIPIIKEHVSKGKFMIGICL
GMQLLYEKSYEYGEYEGLGLIKGSIDKLDISLKVPHMGWNNLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFS
EYEKKIPAIVRKGNVYGIQFHPEKSGEVGLNILRAYGEMIK

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=198, Percent_Identity=38.8888888888889, Blast_Score=136, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319725, Length=206, Percent_Identity=31.0679611650485, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22570; Mature: 22570

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILPGVGAFRDSISALDKLG
CEEEEECCCCCHHHHHHHHHHCCCCCHHHCCHHHHHHCCCEECCCCHHHHHHHHHHHHCC
LIPIIKEHVSKGKFMIGICLGMQLLYEKSYEYGEYEGLGLIKGSIDKLDISLKVPHMGWN
CHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEECCCCCCC
NLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFSEYEKKIPAIVRKGNVYGIQF
CEEECCCCHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEHHHHHHHHHHEECCCEEEEEE
HPEKSGEVGLNILRAYGEMIK
CCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILPGVGAFRDSISALDKLG
CEEEEECCCCCHHHHHHHHHHCCCCCHHHCCHHHHHHCCCEECCCCHHHHHHHHHHHHCC
LIPIIKEHVSKGKFMIGICLGMQLLYEKSYEYGEYEGLGLIKGSIDKLDISLKVPHMGWN
CHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEECCCCCCC
NLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFSEYEKKIPAIVRKGNVYGIQF
CEEECCCCHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEHHHHHHHHHHEECCCEEEEEE
HPEKSGEVGLNILRAYGEMIK
CCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471 [H]