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The map label for this gene is hisB

Identifier: 126699154

GI number: 126699154

Start: 1798477

End: 1799055

Strand: Direct

Name: hisB

Synonym: CD1550

Alternate gene names: 126699154

Gene position: 1798477-1799055 (Clockwise)

Preceding gene: 126699153

Following gene: 126699155

Centisome position: 41.92

GC content: 30.92

Gene sequence:

>579_bases
ATGAGAATTTGGAAGGTAGAAAGAAATACTCTTGAAACACAGATTTTAGTAGAATTAAATATTGATGGTTCTGGTAAAGC
TGAAATAGATACTGGAATAGGATTTTTAGACCATATGCTTACCTTAATGTCATTTCATGGCAAGTTCGATTTAAAAGTGA
TTTGTAAGGGTGATACATATGTAGATGACCACCATAGTGTAGAAGATATAGGTATAGCTATAGGTGAAGCATTTAAAAAT
GCTCTAGGTGACAAAAAAGGAATACGAAGATATTCTAATATCTATATACCTATGGATGAATCTCTATCAATGGTAGCAAT
AGATATAAGCAATAGACCTTATCTTGTATTTAATGCTAAATTTGATACCCAAATGATTGGTAGTATGAGTACTCAATGCT
TTAAAGAATTTTTTAGAGCTTTTGTAAATGAATCGAGAGTAACATTACATATCAATCTCTTATATGGGGAAAATGACCAT
CATAAGATAGAAAGTATTTTTAAAGCATTTGCAAGAGCTTTAAAAGAGGGTAGTGAAATAGTTTCTAATGAGATAGCATC
TTCAAAGGGGGTTTTGTAG

Upstream 100 bases:

>100_bases
GAAAGTTAGAAAATTATTACAGAGTTACAATTGGTGATAAAGAAGAAAATTCTATGTTTGTTGGAGCTATAAGAGATATT
TTGAAAAAGGAGAAATAGGT

Downstream 100 bases:

>100_bases
AATGAATATAATAGTAGACTATGGTCTTGGAAATATAGATTCTGTGTCTAGGGGTTTTAGAAAAGCTGGAATAGAAACTA
AAATTTCTAGTGATATAGAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMSFHGKFDLKVICKGDTYVDDHHSVEDIGIAIGEAFKN
ALGDKKGIRRYSNIYIPMDESLSMVAIDISNRPYLVFNAKFDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDH
HKIESIFKAFARALKEGSEIVSNEIASSKGVL

Sequences:

>Translated_192_residues
MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMSFHGKFDLKVICKGDTYVDDHHSVEDIGIAIGEAFKN
ALGDKKGIRRYSNIYIPMDESLSMVAIDISNRPYLVFNAKFDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDH
HKIESIFKAFARALKEGSEIVSNEIASSKGVL
>Mature_192_residues
MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMSFHGKFDLKVICKGDTYVDDHHSVEDIGIAIGEAFKN
ALGDKKGIRRYSNIYIPMDESLSMVAIDISNRPYLVFNAKFDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDH
HKIESIFKAFARALKEGSEIVSNEIASSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=48.6910994764398, Blast_Score=191, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=45.4545454545455, Blast_Score=167, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CLOD6 (Q18C69)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088051.1
- ProteinModelPortal:   Q18C69
- SMR:   Q18C69
- STRING:   Q18C69
- GeneID:   4913341
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1550
- NMPDR:   fig|1496.1.peg.3368
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21685; Mature: 21685

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMSFHGKFDLKVICKGDTY
CEEEEECCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCE
VDDHHSVEDIGIAIGEAFKNALGDKKGIRRYSNIYIPMDESLSMVAIDISNRPYLVFNAK
ECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCEEEECCCCCEEEEEEECCCCEEEEECC
FDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDHHKIESIFKAFARALKEGSEI
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHH
VSNEIASSKGVL
HHHHHHHCCCCC
>Mature Secondary Structure
MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMSFHGKFDLKVICKGDTY
CEEEEECCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCE
VDDHHSVEDIGIAIGEAFKNALGDKKGIRRYSNIYIPMDESLSMVAIDISNRPYLVFNAK
ECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCEEEECCCCCEEEEEEECCCCEEEEECC
FDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDHHKIESIFKAFARALKEGSEI
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHH
VSNEIASSKGVL
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA