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The map label for this gene is tyrR [H]

Identifier: 126699125

GI number: 126699125

Start: 1763201

End: 1764409

Strand: Direct

Name: tyrR [H]

Synonym: CD1521

Alternate gene names: 126699125

Gene position: 1763201-1764409 (Clockwise)

Preceding gene: 126699124

Following gene: 126699127

Centisome position: 41.1

GC content: 30.77

Gene sequence:

>1209_bases
ATGAAATCGATAGACGAGCAAATGCGAATAATTATGAAAGGTGTAGATGATTTAATAGATGAGAAAGAGTTAAGGGAAAA
GCTTATTAAATCAGAAAAAGAAGGAAAACCTATGATAGTAAAATTGGGTCTAGACCCAAGTGCTCCAGATATACATTTAG
GGCATACAGTAGTTCTTAGAAAGATGAAACAATTACAAGATTTAGGTCATCAAATAGTAATAATAATTGGAGATTTTACA
GGAAAAATTGGAGACCCAACTGGAAAATCTAAAGCTAGAAAAGCTTTAACAACAGAGCAAGTTCTTGCAAATGCAAAAAC
TTATGAAGAACAAATTTTCAAAGTTTTAGATAAAGAAAAAACTATTGTAAGATTTAATAGCGAGTGGTTAGCTAAGTTAA
ATTTTGAAGATGTAATAAAATTAGCAGCAACTATTACTGTTGCGAGAATGTTAGAAAGAGAAGATTTTAAAAAGAGATAT
GAAGGACAAATGCCAATATCAGTACATGAGTTCTTCTACCCATTAATGCAAGCATATGACTCTATAGCATTAGAAGCTGA
TATAGAACTTGGTGGAACTGACCAAAGATTCAATTTACTAATGGGAAGATCATTACAAAGAGAATTTGGTATGGAGTCTC
AAATAGTAATAATGATGCCTTTAATAGAAGGATTAGATGGTAAAGAAAAAATGAGTAAGAGTTTAGGTAACTATATTGGA
ATAGATGAAGAAGCGGGAATAATGTACCAAAAATCTATGGAAATTCCTGATGAACTTATAATTAAATACTACAATTTAGT
GACAGATGTTCATCCTGATGAAGTTAATAAAATAGAATCTCAGTTGAAAGAGGGTTCAGTAAACCCAAGAGATATAAAGA
TGAACTTAGCAAGAGAAATAGTAACATTATACCATGGAGAAGAATCTGCTAAAGAAGCTGAAGAAAGATTTAAATCTGTA
TTCCAAAAAGGTCAAATACCTGAAGATATACAAACAATTCAAGTTAAGGAAGATGGATTTGACTTAATCGAAGTACTAGT
TTCTAATGAGATTGTTAAGAGTAAGAGTGAAGTTAGAAGATTAGCTTCTCAAGGTGGAGTAAAGGTAAATGGTGAAAAAG
TAGAGGATTTAAGCACTATTGTAAAAGAGAGTGAATTAGTTGTTCAAATAGGAAAGAAAAAATTTGTAAAAATCGAGCTA
GTAAAATAG

Upstream 100 bases:

>100_bases
ACACGTAAGCAATGCTTTCGTCCTTTTAAGAGGATGAAAGCTTTTTTTATTATAAAAATAAAAATTATAGATTATATAAA
TATTTTAGGAGGAATGAAAA

Downstream 100 bases:

>100_bases
AGTAAAGTAAAAGCAAGTCTATTGAGTATAAAATGTACATTCAATAAACTTGCTTTTTTATTATATTAAAATTTTAAATT
GATAACCATTGTCTTTAAAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase 2; TyrRS 2 [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGLDPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFT
GKIGDPTGKSKARKALTTEQVLANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRY
EGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIMMPLIEGLDGKEKMSKSLGNYIG
IDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVNKIESQLKEGSVNPRDIKMNLAREIVTLYHGEESAKEAEERFKSV
FQKGQIPEDIQTIQVKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGKKKFVKIEL
VK

Sequences:

>Translated_402_residues
MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGLDPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFT
GKIGDPTGKSKARKALTTEQVLANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRY
EGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIMMPLIEGLDGKEKMSKSLGNYIG
IDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVNKIESQLKEGSVNPRDIKMNLAREIVTLYHGEESAKEAEERFKSV
FQKGQIPEDIQTIQVKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGKKKFVKIEL
VK
>Mature_402_residues
MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGLDPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFT
GKIGDPTGKSKARKALTTEQVLANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRY
EGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIMMPLIEGLDGKEKMSKSLGNYIG
IDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVNKIESQLKEGSVNPRDIKMNLAREIVTLYHGEESAKEAEERFKSV
FQKGQIPEDIQTIQVKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGKKKFVKIEL
VK

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=411, Percent_Identity=25.3041362530414, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787925, Length=413, Percent_Identity=27.8450363196126, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25145802, Length=375, Percent_Identity=25.6, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325160, Length=445, Percent_Identity=26.5168539325843, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130383, Length=401, Percent_Identity=25.6857855361596, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45733; Mature: 45733

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGLDPSAPDIHLGHTVVLR
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEECCHHHHHH
KMKQLQDLGHQIVIIIGDFTGKIGDPTGKSKARKALTTEQVLANAKTYEEQIFKVLDKEK
HHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRYEGQMPISVHEFFYPLMQAYD
EEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIMMPLIEGLDGKEKMSKSLGNYIG
HHEEEEEEEECCCCHHHHHHHCCHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHCCCCC
IDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVNKIESQLKEGSVNPRDIKMNLAREI
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VTLYHGEESAKEAEERFKSVFQKGQIPEDIQTIQVKEDGFDLIEVLVSNEIVKSKSEVRR
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LASQGGVKVNGEKVEDLSTIVKESELVVQIGKKKFVKIELVK
HHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGLDPSAPDIHLGHTVVLR
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEECCHHHHHH
KMKQLQDLGHQIVIIIGDFTGKIGDPTGKSKARKALTTEQVLANAKTYEEQIFKVLDKEK
HHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRYEGQMPISVHEFFYPLMQAYD
EEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIMMPLIEGLDGKEKMSKSLGNYIG
HHEEEEEEEECCCCHHHHHHHCCHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHCCCCC
IDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVNKIESQLKEGSVNPRDIKMNLAREI
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VTLYHGEESAKEAEERFKSVFQKGQIPEDIQTIQVKEDGFDLIEVLVSNEIVKSKSEVRR
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LASQGGVKVNGEKVEDLSTIVKESELVVQIGKKKFVKIELVK
HHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]