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The map label for this gene is yclK [H]

Identifier: 126699069

GI number: 126699069

Start: 1693059

End: 1694312

Strand: Direct

Name: yclK [H]

Synonym: CD1465

Alternate gene names: 126699069

Gene position: 1693059-1694312 (Clockwise)

Preceding gene: 126699068

Following gene: 126699070

Centisome position: 39.46

GC content: 26.24

Gene sequence:

>1254_bases
GTGAAAATAGTGTTTCTATATAATCCAGAAGTGAAGAAGTTTTTAAGTAAGTATGTTACTTTGATGTTTATTGTTATCAT
AATATCTATTGGATTTAGCATAATCAACGTGTCCTTAACTAAAGAGATGGTTGTAAGAAATAATCAGGCTATAATAGGAA
CTTTATCAAGCAAGTATCCAAACTTAGAAAGTCAGATAGTAGACATAATAACTCAAGGGAAGTCTATGGAGAACATAGAT
TATGGTCAGAAAATATTAATTAAGTATAATTATGATAAATCTATTAGGATAAACTCTGAGCCTATTATTTCTAAATTAGT
TTTAGAGACTATCAAAATAAATATAATATTAGTATGTATAATATTTATTTTGATATTTGTGTTGATTGTTAGATATTTTA
CGTCAATTTACAATGATTTATCAGATATGACTAAGTATGTTTACTATAGTTCAGAGGGTAAGCCATTTGATATGAAAAAC
AAGAATCAAGAAGGGCAGATAGGTCTTCTAAAAACTGAACTCTTAAAAATGACGACAATTCTTAATGAAAAGGTTGAACT
TTTAAAAAGAGAAAAGATATTTTTAAACAATACAATTTCCGATATATCACATCAATTAAAAACTCCTATGACTTCTTTAA
TAATGTTGAATGATTTATTATATAATGATGTACCATACGAAGTAAAAATCGATTTTTTAAATAAGATAAAAAATCAATTA
AATAGAATGGATTGGTTGATTAAAAGCATGCTTAAATTATCAAAGGTAGAAGCAAAAGTGATAAATTTTAAAAAAGATAA
GGTAAAATTTAGTGAACTCATACATAGAGCAATGCTATCTATGAAAATACCTATGGAGATTAAAAATCAAAAACTGACTA
TAGAGGGAAATGATAATGTATCTTATATTGGTGATATTGATTGGTCCGTGGAAGCATTAGTGAATATAATCAAAAATTGT
GTAGAACATACTCCTGAATTTGGAAATATAATTATAACCTATAAAGAAAATCCATTATTTTCTGAACTAATAATAAAAGA
TGAGGGTGAAGGTATAGATAAAAAAGATATACCACATGTATTTAAACGATTCTATAGAGGAAGAAGTAGTTCAAAAGAAG
ATAGTGTAGGAATAGGTCTTGCAATGTCAAAATCTATAATAGAAAGCCAAAATGGCGATATATATGTAAACAGCGAAAAA
GGTAAGGGTACAGAATTTCATATAATATTTCATAAAATGTATGATAGTGACTAA

Upstream 100 bases:

>100_bases
ACTGTTTATATAAAAAGGCTTAGAGAAAAAATAGGTGATGATTTATGTGAACCAATCTACATAGAAACTGTAAGGGGGAT
TGGTTATAAATGGATAGGAA

Downstream 100 bases:

>100_bases
TCTGTAATATTTAATTCACTTTATAGTAATAGCCAAAACCTAATATATGAAGTATAGAATATAAATATTGGAGGTAGTTA
TGGAAATTTTAAGAGTAGAA

Product: two-component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKIVFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRNNQAIIGTLSSKYPNLESQIVDIITQGKSMENID
YGQKILIKYNYDKSIRINSEPIISKLVLETIKINIILVCIIFILIFVLIVRYFTSIYNDLSDMTKYVYYSSEGKPFDMKN
KNQEGQIGLLKTELLKMTTILNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLYNDVPYEVKIDFLNKIKNQL
NRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAMLSMKIPMEIKNQKLTIEGNDNVSYIGDIDWSVEALVNIIKNC
VEHTPEFGNIIITYKENPLFSELIIKDEGEGIDKKDIPHVFKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIYVNSEK
GKGTEFHIIFHKMYDSD

Sequences:

>Translated_417_residues
MKIVFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRNNQAIIGTLSSKYPNLESQIVDIITQGKSMENID
YGQKILIKYNYDKSIRINSEPIISKLVLETIKINIILVCIIFILIFVLIVRYFTSIYNDLSDMTKYVYYSSEGKPFDMKN
KNQEGQIGLLKTELLKMTTILNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLYNDVPYEVKIDFLNKIKNQL
NRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAMLSMKIPMEIKNQKLTIEGNDNVSYIGDIDWSVEALVNIIKNC
VEHTPEFGNIIITYKENPLFSELIIKDEGEGIDKKDIPHVFKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIYVNSEK
GKGTEFHIIFHKMYDSD
>Mature_417_residues
MKIVFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRNNQAIIGTLSSKYPNLESQIVDIITQGKSMENID
YGQKILIKYNYDKSIRINSEPIISKLVLETIKINIILVCIIFILIFVLIVRYFTSIYNDLSDMTKYVYYSSEGKPFDMKN
KNQEGQIGLLKTELLKMTTILNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLYNDVPYEVKIDFLNKIKNQL
NRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAMLSMKIPMEIKNQKLTIEGNDNVSYIGDIDWSVEALVNIIKNC
VEHTPEFGNIIITYKENPLFSELIIKDEGEGIDKKDIPHVFKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIYVNSEK
GKGTEFHIIFHKMYDSD

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=31.1926605504587, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=25.9414225941423, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790861, Length=315, Percent_Identity=21.9047619047619, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=22.3214285714286, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=22.3214285714286, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=22.9166666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=25.4464285714286, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=24.0909090909091, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=293, Percent_Identity=22.8668941979522, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1788713, Length=218, Percent_Identity=22.9357798165138, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=23.4567901234568, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=22.0472440944882, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48200; Mature: 48200

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRNNQAIIGTLSSKYP
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCEEEEECCCCCC
NLESQIVDIITQGKSMENIDYGQKILIKYNYDKSIRINSEPIISKLVLETIKINIILVCI
CHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
IFILIFVLIVRYFTSIYNDLSDMTKYVYYSSEGKPFDMKNKNQEGQIGLLKTELLKMTTI
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHH
LNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLYNDVPYEVKIDFLNKIKNQL
HHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
NRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAMLSMKIPMEIKNQKLTIEGNDNV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCCCE
SYIGDIDWSVEALVNIIKNCVEHTPEFGNIIITYKENPLFSELIIKDEGEGIDKKDIPHV
EEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHEEECCCCCCCCCCHHHH
FKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIYVNSEKGKGTEFHIIFHKMYDSD
HHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MKIVFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRNNQAIIGTLSSKYP
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCEEEEECCCCCC
NLESQIVDIITQGKSMENIDYGQKILIKYNYDKSIRINSEPIISKLVLETIKINIILVCI
CHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
IFILIFVLIVRYFTSIYNDLSDMTKYVYYSSEGKPFDMKNKNQEGQIGLLKTELLKMTTI
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHH
LNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLYNDVPYEVKIDFLNKIKNQL
HHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
NRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAMLSMKIPMEIKNQKLTIEGNDNV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCCCE
SYIGDIDWSVEALVNIIKNCVEHTPEFGNIIITYKENPLFSELIIKDEGEGIDKKDIPHV
EEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHEEECCCCCCCCCCHHHH
FKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIYVNSEKGKGTEFHIIFHKMYDSD
HHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]