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The map label for this gene is infB

Identifier: 126698908

GI number: 126698908

Start: 1518523

End: 1520463

Strand: Direct

Name: infB

Synonym: CD1309

Alternate gene names: 126698908

Gene position: 1518523-1520463 (Clockwise)

Preceding gene: 126698907

Following gene: 126698909

Centisome position: 35.39

GC content: 33.75

Gene sequence:

>1941_bases
GTGTCAAAAACAAGAGTATACCAAATAGCAGAAGAATTAAATATATCAAATGAAGAGCTTATAAATAAGTTAGCTGAATT
AGATATAAATGTAACTGACAAAGATTCAGTATTAGAAGGTGAAGAGTTAGAATTAGCACTTGAAATGTTAGGTGAAGATT
TATCTCAAGAAAATGGAAATGTTATAGAAATAGATGGAAAGTTGACAGTACAAGTATTAGCAACGAAATTAGATAAATCT
CCATCAGAAATAATTATGAAGCTTATGAAAATGGGAACTATGGCAACAATAAATCAAGAGATAAGTTTTGAGATTGCTGC
TTTGGCTGCCAAAGACTATGGATTTGAATTAACAGTAGCTGAAAGTGATGATACAGAAGCTTTAGAAATAGAAGCTTTAA
TGGAAATTGAAGAAGATAAAGAAGAGGATTTAAAACCTAGACCACCAGTTGTTACAGTTATGGGACATGTTGACCATGGT
AAGACATCTTTACTAGATGCAATAAGAAAAACTGATGTGATTTCAGGTGAAGCTGGAGGAATAACTCAGCATATAGGTGC
TTCAGAAGTTAAAATCAATGGACACAAAATAGTATTTTTAGATACTCCAGGACATGAGGCTTTCACATCAATGAGAGCAA
GAGGAGCACAAGTTACAGATATAGCAATATTAGTAGTTGCAGCAGATGATGGTATAATGCCTCAAACAGTTGAAGCTATA
AACCATGCTAAAGCAGCAGGTGTACCTTTAATAGTTGCTATTAATAAAATAGATAAACCAGGTGCAAACCCAGATAAGGT
TAAACAGGAATTAGCAGACCAAGGATTATTAGTTGAAGACTGGGGTGGAGAAGTAATAGCAGTTCCAGTATCAGCTAAGA
AAAAAGAAGGAATAGATACACTTTTAGAAATGGTATTATTGGTTGCTGAAATGGAAGAGTTAAGAGCTAATCCAAATAAA
AGAGCAGTAGGAACTGTTATAGAAGCTGAGCTTGATAAAGGAAGAGGGCCAGTTGCAACAGTACTTGTTCAAGGTGGTAC
TTTAACAGTAGGTGACCCAATCGTTGCAGGTGTTGCATGTGGTAAAGTTAGAGCAATGATAAATGCAAAAGGTAAGAGAG
TAAAAACAGCAGGACCATCTACAGCAGTCGAGATATTAGGTCTATCAGAAGTTCCACAAGGAGGAGACCAATTTGTCGAA
GTTCCAACTGATAAGATTGCTAGAAGTGTAGCAGCAAGAAGACAACAAATAGTTAGAGATGAAATGTTAAAATCAACTCA
AAGATTATCACTAGATGCTCTATTTAGTCAAATGAGTGAAGGTTCTATAAAAGACCTTAATATAGTTATAAAAGCAGATG
TACAAGGTTCAGTACAGGCAGTTAAACAATCTTTAGAAAAATTATCAAATGAAGAAGTTCAAGTTAAAGTAATACATGGT
GGTGTTGGAGCTGTAACAGAATCAGACATATTACTTGCAGCAGCTTCTAACGCAATAATAATAGGATTCAATGTAAGACC
AGTTCCAGGTGCAGAATCTCTAGGAGAAAAAGAAAATGTTGATATAAGAACATATACTATAATATACAAGGCAATAGAAG
ATATACAAGCGGCTATGACTGGTATGTTAGACCCTGAATATGTTGATGAAGAAACAGGAAAAGCTGAAATAAGAGAAATA
TATAAAATATCTGGTGTTGGAACAGTAGCTGGATGTTATGTGACTAATGGTAAGATATTTAGAAATTGTAAAGTAAGATT
AGTTAGAGATAGCATAATAATACATGAAGGTGAGCTTGCAGCACTTAAGAGATTTAAAGATGATGTAAAAGAAGTTAATT
CTGGATACGAATGTGGTATGAGTTTTGTAAATTATAACGACATAAAAGAAGGCGATATAGTAGAAGCTTATATAACTAAA
GAAGTAGAAAGAAAATTATAA

Upstream 100 bases:

>100_bases
AGGAAAATCTCCAAGAGCAGTTGTAGGAATAAAAGATGAAAATTTTTCTAAAAAGATAATTGAACTAATAGAAATTTAAA
ATAAAATAGGGGGTGATCTT

Downstream 100 bases:

>100_bases
ATTCGTATCAAAGAAAATCAGTTAGTAAAGAAGGTCGATGGTATGGCATCATATAATAGAACAAGAAGGATAGCAGAAGA
AATAAGAAAAGTCGTAAGTA

Product: translation initiation factor IF-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELELALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKS
PSEIIMKLMKMGTMATINQEISFEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHG
KTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQVTDIAILVVAADDGIMPQTVEAI
NHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGLLVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNK
RAVGTVIEAELDKGRGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVPQGGDQFVE
VPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVIKADVQGSVQAVKQSLEKLSNEEVQVKVIHG
GVGAVTESDILLAAASNAIIIGFNVRPVPGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREI
YKISGVGTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVNYNDIKEGDIVEAYITK
EVERKL

Sequences:

>Translated_646_residues
MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELELALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKS
PSEIIMKLMKMGTMATINQEISFEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHG
KTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQVTDIAILVVAADDGIMPQTVEAI
NHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGLLVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNK
RAVGTVIEAELDKGRGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVPQGGDQFVE
VPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVIKADVQGSVQAVKQSLEKLSNEEVQVKVIHG
GVGAVTESDILLAAASNAIIIGFNVRPVPGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREI
YKISGVGTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVNYNDIKEGDIVEAYITK
EVERKL
>Mature_645_residues
SKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELELALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKSP
SEIIMKLMKMGTMATINQEISFEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHGK
TSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQVTDIAILVVAADDGIMPQTVEAIN
HAKAAGVPLIVAINKIDKPGANPDKVKQELADQGLLVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNKR
AVGTVIEAELDKGRGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVPQGGDQFVEV
PTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVIKADVQGSVQAVKQSLEKLSNEEVQVKVIHGG
VGAVTESDILLAAASNAIIIGFNVRPVPGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREIY
KISGVGTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVNYNDIKEGDIVEAYITKE
VERKL

Specific function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 7

COG id: COG0532

COG function: function code J; Translation initiation factor 2 (IF-2; GTPase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-2 family

Homologues:

Organism=Homo sapiens, GI53729339, Length=547, Percent_Identity=40.036563071298, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI53729337, Length=547, Percent_Identity=40.036563071298, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI84043963, Length=468, Percent_Identity=29.4871794871795, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI157426893, Length=284, Percent_Identity=27.4647887323944, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789559, Length=579, Percent_Identity=53.713298791019, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI2367247, Length=274, Percent_Identity=32.8467153284672, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI48994988, Length=139, Percent_Identity=35.9712230215827, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788922, Length=227, Percent_Identity=27.7533039647577, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790412, Length=140, Percent_Identity=39.2857142857143, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789737, Length=140, Percent_Identity=39.2857142857143, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994658, Length=558, Percent_Identity=34.7670250896057, Blast_Score=301, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI212656558, Length=468, Percent_Identity=29.2735042735043, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17557151, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17556456, Length=142, Percent_Identity=37.3239436619718, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324550, Length=621, Percent_Identity=36.231884057971, Blast_Score=357, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6319282, Length=471, Percent_Identity=27.1762208067941, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324761, Length=132, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28572034, Length=633, Percent_Identity=38.7045813586098, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24656849, Length=457, Percent_Identity=29.3216630196937, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI160714833, Length=75, Percent_Identity=72, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI78706572, Length=216, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281363316, Length=134, Percent_Identity=37.3134328358209, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17864358, Length=134, Percent_Identity=37.3134328358209, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: 1150 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): IF2_CLOD6 (Q18BH4)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087805.1
- ProteinModelPortal:   Q18BH4
- SMR:   Q18BH4
- STRING:   Q18BH4
- GeneID:   4914468
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1309
- NMPDR:   fig|1496.1.peg.3423
- eggNOG:   COG0532
- HOGENOM:   HBG635083
- OMA:   QYGRIRS
- ProtClustDB:   PRK05306
- GO:   GO:0005737
- HAMAP:   MF_00100_B
- InterPro:   IPR006847
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000178
- InterPro:   IPR015760
- InterPro:   IPR023115
- InterPro:   IPR009000
- Gene3D:   G3DSA:3.40.50.10050
- PANTHER:   PTHR23115:SF41
- TIGRFAMs:   TIGR00487
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF11987 IF-2; PF04760 IF2_N; SSF52156 TIF_IF2_dom3; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 69712; Mature: 69581

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS01176 IF2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELELALEMLGEDLSQENGN
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
VIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEISFEIAALAAKDYGFELTVA
EEEECCCEEEEEHHHHHCCCHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCEEEEEE
ESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHGKTSLLDAIRKTDVISGEAGG
CCCCCCCEEHHHHHHHHCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCC
ITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQVTDIAILVVAADDGIMPQTVEAI
CHHCCCCCEEEECCEEEEEEECCCHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHH
NHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGLLVEDWGGEVIAVPVSAKKKEGIDT
HHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCHHH
LLEMVLLVAEMEELRANPNKRAVGTVIEAELDKGRGPVATVLVQGGTLTVGDPIVAGVAC
HHHHHHHHHHHHHHHCCCCCCHHHHHEEEHHCCCCCCEEEEEEECCEEEECCHHHHHHHH
GKVRAMINAKGKRVKTAGPSTAVEILGLSEVPQGGDQFVEVPTDKIARSVAARRQQIVRD
HHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHH
EMLKSTQRLSLDALFSQMSEGSIKDLNIVIKADVQGSVQAVKQSLEKLSNEEVQVKVIHG
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEC
GVGAVTESDILLAAASNAIIIGFNVRPVPGAESLGEKENVDIRTYTIIYKAIEDIQAAMT
CCCCCCCCCEEEEECCCEEEEEEEECCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHHHH
GMLDPEYVDEETGKAEIREIYKISGVGTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELA
CCCCCHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECCEEEECCEEEEEEEEEEEECCHHH
ALKRFKDDVKEVNSGYECGMSFVNYNDIKEGDIVEAYITKEVERKL
HHHHHHHHHHHHCCCHHHCCEEECCCCCCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
SKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELELALEMLGEDLSQENGN
CCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
VIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEISFEIAALAAKDYGFELTVA
EEEECCCEEEEEHHHHHCCCHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCEEEEEE
ESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHGKTSLLDAIRKTDVISGEAGG
CCCCCCCEEHHHHHHHHCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCC
ITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQVTDIAILVVAADDGIMPQTVEAI
CHHCCCCCEEEECCEEEEEEECCCHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHH
NHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGLLVEDWGGEVIAVPVSAKKKEGIDT
HHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCHHH
LLEMVLLVAEMEELRANPNKRAVGTVIEAELDKGRGPVATVLVQGGTLTVGDPIVAGVAC
HHHHHHHHHHHHHHHCCCCCCHHHHHEEEHHCCCCCCEEEEEEECCEEEECCHHHHHHHH
GKVRAMINAKGKRVKTAGPSTAVEILGLSEVPQGGDQFVEVPTDKIARSVAARRQQIVRD
HHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHH
EMLKSTQRLSLDALFSQMSEGSIKDLNIVIKADVQGSVQAVKQSLEKLSNEEVQVKVIHG
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEC
GVGAVTESDILLAAASNAIIIGFNVRPVPGAESLGEKENVDIRTYTIIYKAIEDIQAAMT
CCCCCCCCCEEEEECCCEEEEEEEECCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHHHH
GMLDPEYVDEETGKAEIREIYKISGVGTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELA
CCCCCHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECCEEEECCEEEEEEEEEEEECCHHH
ALKRFKDDVKEVNSGYECGMSFVNYNDIKEGDIVEAYITKEVERKL
HHHHHHHHHHHHCCCHHHCCEEECCCCCCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA