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The map label for this gene is iscS2 [H]

Identifier: 126698876

GI number: 126698876

Start: 1485277

End: 1486470

Strand: Direct

Name: iscS2 [H]

Synonym: CD1279

Alternate gene names: 126698876

Gene position: 1485277-1486470 (Clockwise)

Preceding gene: 126698875

Following gene: 126698877

Centisome position: 34.62

GC content: 31.99

Gene sequence:

>1194_bases
ATGGAAAAAAGAAGATTGTATATGGATTATTCTGCAACAACACCTATTAAAAAAGAAGTATTGGATGCAATGATGCCATA
CCTAACAGATTATTTTGGTAATGCATCTAGTTTTCACACATTCGGAAGAGAAGCAAAAGATGCTTTGGATAAAGCAAGAG
AACAAGTAGCAGCCCTTATAAATGCTGAACCTAGTGAAATATATTTTACAGCAGGTGGTTCAGAAAGTGATAACTGGACA
CTAGAGGGTATAGCTTATGCTAATAAAAACAAAGGTAATCATATAATAACTTCAAAAATAGAACACCATGCAATACTTCA
TACATGTGAATACTTAGCAAAACATCATGGATTTGAAATAACTTATTTAGATGTTGATAGCGAAGGAAAAGTAGACTTAA
AGCAACTAGAAGATTCAATAAAAGATACTACTATACTTATAAGTATAATGTTTGCAAATAATGAAATAGGAACTATACAG
CCTATTAAAGAAATATCCGAAATAGCTAAAAAACATAAGATATTATTCCACACTGATGCAGTACAAGCTACAGGTAATAT
TCCAGTAGATGTTAAAGAATTAGGAATAGATTTGATGAGTATGTCTTCACATAAAATATATGGACCAAAAGGTGTAGGAG
CTTTATACATAAGAAAAGGTGTAAGACTTCATAACTTTGTTCATGGTGGAGCACAAGAAAAAAGCAAAAGAGCTGGTACA
GAAAATATACCTGCAATAGTTGGATATGGAAAAGCAGCAGAATTAGCTAAGGAAAATATGCAAAATCATGTAGAAACTTT
AACTCGTCTTAGAAATAAGTTAATAGATGGTGTGTTAGAAAGAATACCTTACACAAGAGTAAATGGTAGCTTAGAAAATA
GATTGCCAGGAAATGCAAACTTTGCATTCCAATTTATAGAAGGTGAAGGAATACTTTTATTATTAGATATGTTAGGAATT
GCTGGTTCAAGTGGTTCTGCATGTACTTCTGGTTCATTAGACCCTTCACATGTACTTCTTGCAATAGGTTTACCACATGA
AATAGCACATGGTTCATTAAGACTTACAGTTGGAGATTTTACAACAGATGATGATATAGATTATATACTAGAGAACTTAC
CAAAAGTAATAGAAAGACTTAGAAGCATGTCACCACTTTATGATGATGCGAAGAAACAAGGTTTAGTAAAATAG

Upstream 100 bases:

>100_bases
TAGATTCAATTACTCTTAAAGATATGATAAATGACTATAACAAAAATAAATTAGAAAATGATATAACAAATATTAAAAAA
TAGATTTGGAGATGAATGTA

Downstream 100 bases:

>100_bases
ACATAAAGATAAAGCATAAAAAATAGACATAAATTGAGTAGGAGGAAAAGATAATGCAATATAGTGATAAAGTTATGGAA
CATTTTATGAATCCAAGAAA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGREAKDALDKAREQVAALINAEPSEIYFTAGGSESDNWT
LEGIAYANKNKGNHIITSKIEHHAILHTCEYLAKHHGFEITYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQ
PIKEISEIAKKHKILFHTDAVQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIRKGVRLHNFVHGGAQEKSKRAGT
ENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLIDGVLERIPYTRVNGSLENRLPGNANFAFQFIEGEGILLLLDMLGI
AGSSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRLTVGDFTTDDDIDYILENLPKVIERLRSMSPLYDDAKKQGLVK

Sequences:

>Translated_397_residues
MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGREAKDALDKAREQVAALINAEPSEIYFTAGGSESDNWT
LEGIAYANKNKGNHIITSKIEHHAILHTCEYLAKHHGFEITYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQ
PIKEISEIAKKHKILFHTDAVQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIRKGVRLHNFVHGGAQEKSKRAGT
ENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLIDGVLERIPYTRVNGSLENRLPGNANFAFQFIEGEGILLLLDMLGI
AGSSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRLTVGDFTTDDDIDYILENLPKVIERLRSMSPLYDDAKKQGLVK
>Mature_397_residues
MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGREAKDALDKAREQVAALINAEPSEIYFTAGGSESDNWT
LEGIAYANKNKGNHIITSKIEHHAILHTCEYLAKHHGFEITYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQ
PIKEISEIAKKHKILFHTDAVQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIRKGVRLHNFVHGGAQEKSKRAGT
ENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLIDGVLERIPYTRVNGSLENRLPGNANFAFQFIEGEGILLLLDMLGI
AGSSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRLTVGDFTTDDDIDYILENLPKVIERLRSMSPLYDDAKKQGLVK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=46.6494845360825, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=35.5072463768116, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=48.1012658227848, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1787970, Length=341, Percent_Identity=26.9794721407625, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1789175, Length=396, Percent_Identity=25.5050505050505, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=46.2532299741602, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17533177, Length=323, Percent_Identity=32.8173374613003, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319831, Length=388, Percent_Identity=46.6494845360825, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI20129463, Length=390, Percent_Identity=47.1794871794872, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43820; Mature: 43820

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00595 AA_TRANSFER_CLASS_5 ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGREAKDALDKAREQVAALI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NAEPSEIYFTAGGSESDNWTLEGIAYANKNKGNHIITSKIEHHAILHTCEYLAKHHGFEI
CCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHCCCEE
TYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQPIKEISEIAKKHKILFHTDA
EEEEECCCCCCHHHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECC
VQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIRKGVRLHNFVHGGAQEKSKRAGT
HHCCCCCCEEHHHHCCHHEECCCCCEECCCCCCCHHHHCCCHHHHHHCCCCHHHHHHCCC
ENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLIDGVLERIPYTRVNGSLENRLPGNAN
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHCCCCCCC
FAFQFIEGEGILLLLDMLGIAGSSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRLTVGDF
EEEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCEEEEEECCC
TTDDDIDYILENLPKVIERLRSMSPLYDDAKKQGLVK
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
>Mature Secondary Structure
MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGREAKDALDKAREQVAALI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NAEPSEIYFTAGGSESDNWTLEGIAYANKNKGNHIITSKIEHHAILHTCEYLAKHHGFEI
CCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHCCCEE
TYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQPIKEISEIAKKHKILFHTDA
EEEEECCCCCCHHHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECC
VQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIRKGVRLHNFVHGGAQEKSKRAGT
HHCCCCCCEEHHHHCCHHEECCCCCEECCCCCCCHHHHCCCHHHHHHCCCCHHHHHHCCC
ENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLIDGVLERIPYTRVNGSLENRLPGNAN
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHCCCCCCC
FAFQFIEGEGILLLLDMLGIAGSSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRLTVGDF
EEEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCEEEEEECCC
TTDDDIDYILENLPKVIERLRSMSPLYDDAKKQGLVK
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA