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The map label for this gene is glcD [H]

Identifier: 126698768

GI number: 126698768

Start: 1372065

End: 1373456

Strand: Direct

Name: glcD [H]

Synonym: CD1173

Alternate gene names: 126698768

Gene position: 1372065-1373456 (Clockwise)

Preceding gene: 126698767

Following gene: 126698770

Centisome position: 31.98

GC content: 29.89

Gene sequence:

>1392_bases
ATGTATAAATTAATTGATAAAAAAGATATAGATTTTTTAATAGATACTTGTGGAGAAGAAAATGTATTAGTTGGAAGTGA
TATAAATGAAGATTTTTCACATGATGAACTTGGAGGGATTGAGAAGTACCCTGAAGTTTTAGTAAATGTACTTGAAACTG
AACAAGTATCTAAAATAATGAAATACGCATATAAAAATAATATACCAGTCACACCAAGAGGTCAAGGTACTGGTCTTGTA
GGTGCTGCTGTTGCCATAAATGGTGGAATAATGATTAATCTATGTAAAATGAATAAAATACTTGAAGTTGATTATGAAAA
TTTAACATTGACAGTAGAACCAGGTGTTTTATTGATGACAATAGGTCAATATGTTCAAGATAGAGATTTATTTTACCCAC
CTGACCCAGGTGAAAAAAGTGCTACAATTGCAGGTAATATAAACACTAATGCAGGTGGTATGAGAGCAGTAAAATATGGC
GTTACAAGGGATTATGTAAGAGGTCTTGAAGTTGTACTACCAAATGGAGAAATTATAAATGTAGGTGGAAAGGTAGTTAA
AAATAGTTCTGGATATAGTATAAAGGATTTATTAGTGGGCTCAGAAGGTACTTTAGGAATAGTTACTAAAGCTATATTAA
AATTGCTTCCTTTACCAAAGAAAAGTATAAGTTTGCTTATACCATTTCCAGATTTATCAATGGCAATAGAAACTGTTCCT
AAAATAATAAAATCAAAATCAATACCAACGGCTATAGAATTTATGGAAAGAGATGTAATATTGGCAGCAGAAGAATTTTT
AGGTAAAAAGTTTCCAGATAATACATCAGATGCTTATCTTTTGCTTACATTTGATGGAAATAGCACTGAAGATATAGAAA
AAGAATATGAAAAAGTAGCTAATTTATGTTTAGAAAATGGTGCATTAGATGTATTTATATCAGATACACAAGAAAGAAAC
GATTCTATATGGTCAGCCAGAGGTGCATTTTTAGAAGCTATAAAGGCATCTACGACACAAATGGATGAATGTGATGTCGT
TGTTCCAAGAGATAAGATAGCAGAGTTTATAAGATACACTCACGAGCTTCAAGACAAATTAAAAATAAGAATAAAAAGTT
TTGGTCATGCAGGAGATGGAAATCTACACATATATATTTTAAAAGATGGTATGGATGATAATACATGGAAAATAAGATTA
AAAGAAACTTTTGACTATATGTATAAAAAATCTAGAGAACTTAGTGGTCAAGTTTCTGGTGAACATGGCATAGGATATGC
TAAAAAAGAGTACTTACATGAATCAAATTCAGATGCTTATATGATGTTAATTAAAAATATAAAGTTAGCTTTTGACCCTA
AAAATATTTTAAATCCAGGAAAAATATATTAG

Upstream 100 bases:

>100_bases
GATATTTATGATATTATTCCTAAATTGATTGAAAAAATAGAAAATAACAAAGATAATAATCAAAAATATATGGCATCAGC
AGCTAAATAGGGGGATAGAA

Downstream 100 bases:

>100_bases
AAATATTAATTTAATAATATTTATAAAACAAAAAATATTAAATTAGATTTAAATATAATATTTTAAACTTTACTTTTAAA
TCTGAAGCTAAATTGTAAAA

Product: FAD/FMN-containing dehydrogenase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYPEVLVNVLETEQVSKIMKYAYKNNIPVTPRGQGTGLV
GAAVAINGGIMINLCKMNKILEVDYENLTLTVEPGVLLMTIGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYG
VTRDYVRGLEVVLPNGEIINVGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPLPKKSISLLIPFPDLSMAIETVP
KIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTSDAYLLLTFDGNSTEDIEKEYEKVANLCLENGALDVFISDTQERN
DSIWSARGAFLEAIKASTTQMDECDVVVPRDKIAEFIRYTHELQDKLKIRIKSFGHAGDGNLHIYILKDGMDDNTWKIRL
KETFDYMYKKSRELSGQVSGEHGIGYAKKEYLHESNSDAYMMLIKNIKLAFDPKNILNPGKIY

Sequences:

>Translated_463_residues
MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYPEVLVNVLETEQVSKIMKYAYKNNIPVTPRGQGTGLV
GAAVAINGGIMINLCKMNKILEVDYENLTLTVEPGVLLMTIGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYG
VTRDYVRGLEVVLPNGEIINVGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPLPKKSISLLIPFPDLSMAIETVP
KIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTSDAYLLLTFDGNSTEDIEKEYEKVANLCLENGALDVFISDTQERN
DSIWSARGAFLEAIKASTTQMDECDVVVPRDKIAEFIRYTHELQDKLKIRIKSFGHAGDGNLHIYILKDGMDDNTWKIRL
KETFDYMYKKSRELSGQVSGEHGIGYAKKEYLHESNSDAYMMLIKNIKLAFDPKNILNPGKIY
>Mature_463_residues
MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYPEVLVNVLETEQVSKIMKYAYKNNIPVTPRGQGTGLV
GAAVAINGGIMINLCKMNKILEVDYENLTLTVEPGVLLMTIGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYG
VTRDYVRGLEVVLPNGEIINVGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPLPKKSISLLIPFPDLSMAIETVP
KIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTSDAYLLLTFDGNSTEDIEKEYEKVANLCLENGALDVFISDTQERN
DSIWSARGAFLEAIKASTTQMDECDVVVPRDKIAEFIRYTHELQDKLKIRIKSFGHAGDGNLHIYILKDGMDDNTWKIRL
KETFDYMYKKSRELSGQVSGEHGIGYAKKEYLHESNSDAYMMLIKNIKLAFDPKNILNPGKIY

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=459, Percent_Identity=31.1546840958606, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI37595754, Length=482, Percent_Identity=29.6680497925311, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI119964728, Length=433, Percent_Identity=29.0993071593533, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4501993, Length=474, Percent_Identity=25.5274261603376, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1789351, Length=432, Percent_Identity=31.712962962963, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=25.5020080321285, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI48994907, Length=452, Percent_Identity=22.1238938053097, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994914, Length=129, Percent_Identity=34.8837209302326, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=451, Percent_Identity=31.9290465631929, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71992381, Length=451, Percent_Identity=30.5986696230599, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71992392, Length=381, Percent_Identity=31.496062992126, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17534361, Length=436, Percent_Identity=28.8990825688073, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17556096, Length=468, Percent_Identity=23.7179487179487, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320023, Length=479, Percent_Identity=29.8538622129436, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320764, Length=494, Percent_Identity=30.7692307692308, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6320027, Length=435, Percent_Identity=29.4252873563218, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18921117, Length=420, Percent_Identity=30.7142857142857, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24639277, Length=420, Percent_Identity=30.7142857142857, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24639275, Length=420, Percent_Identity=30.7142857142857, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24653753, Length=228, Percent_Identity=26.7543859649123, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51477; Mature: 51477

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYPEVLVNVLETEQVSKIM
CCCCCCCCCCHHHEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KYAYKNNIPVTPRGQGTGLVGAAVAINGGIMINLCKMNKILEVDYENLTLTVEPGVLLMT
HHHHHCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCEEEEECCCEEEEECCCEEEEE
IGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYGVTRDYVRGLEVVLPNGEIIN
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCHHHHCCEEEEECCCCEEE
VGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPLPKKSISLLIPFPDLSMAIETVP
CCCEEEECCCCCEEEHEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHH
KIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTSDAYLLLTFDGNSTEDIEKEYEKVA
HHHHCCCCCHHHHHHHCCHHEEHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHH
NLCLENGALDVFISDTQERNDSIWSARGAFLEAIKASTTQMDECDVVVPRDKIAEFIRYT
HHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHH
HELQDKLKIRIKSFGHAGDGNLHIYILKDGMDDNTWKIRLKETFDYMYKKSRELSGQVSG
HHHHHHHEEEEEECCCCCCCCEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCC
EHGIGYAKKEYLHESNSDAYMMLIKNIKLAFDPKNILNPGKIY
CCCCCHHHHHHHHCCCCCEEEEEEECCEEEECCHHCCCCCCCC
>Mature Secondary Structure
MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYPEVLVNVLETEQVSKIM
CCCCCCCCCCHHHEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KYAYKNNIPVTPRGQGTGLVGAAVAINGGIMINLCKMNKILEVDYENLTLTVEPGVLLMT
HHHHHCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCEEEEECCCEEEEECCCEEEEE
IGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYGVTRDYVRGLEVVLPNGEIIN
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCHHHHCCEEEEECCCCEEE
VGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPLPKKSISLLIPFPDLSMAIETVP
CCCEEEECCCCCEEEHEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHH
KIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTSDAYLLLTFDGNSTEDIEKEYEKVA
HHHHCCCCCHHHHHHHCCHHEEHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHH
NLCLENGALDVFISDTQERNDSIWSARGAFLEAIKASTTQMDECDVVVPRDKIAEFIRYT
HHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHH
HELQDKLKIRIKSFGHAGDGNLHIYILKDGMDDNTWKIRLKETFDYMYKKSRELSGQVSG
HHHHHHHEEEEEECCCCCCCCEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCC
EHGIGYAKKEYLHESNSDAYMMLIKNIKLAFDPKNILNPGKIY
CCCCCHHHHHHHHCCCCCEEEEEEECCEEEECCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]