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The map label for this gene is hom1 [H]

Identifier: 126698761

GI number: 126698761

Start: 1364274

End: 1365479

Strand: Direct

Name: hom1 [H]

Synonym: CD1166

Alternate gene names: 126698761

Gene position: 1364274-1365479 (Clockwise)

Preceding gene: 126698760

Following gene: 126698764

Centisome position: 31.8

GC content: 28.77

Gene sequence:

>1206_bases
GTGAAGATAGCAATATTAGGGTATGGAACAGTAGGAAGTGGATTAATTGATTTAATAGAAAATAATACTTCAAAAAGAGA
TATAGAAGTTGTTGGAATTTTAGTTAAAAATAAAGAAAAACACAAGTATAAGAAGTATTTTGATAAGATAACTACTGATA
TAGAAGATATATTTGACAAGGATATTGATATACTAGTTGAAGTAATTGGAGGATTAAATCCAGCTTTTGATTATGTAACA
AGAGCGTTAAATAAAAAAATACATGTAGTGACAGCTAATAAAGATTTACTGGCTGAAAAAGGTAGTGACCTTATAGAATT
AGCTAACTTAAATAATGTTAGCATCAAGTTTGAAGCATCTGTGGCAGGTGGTATTCCAGTTTTAAAACCATTGATAGAAT
CACTGGAAGGCAACAATATAAAGAGCATAAACGCTATTTTAAATGGGACTTGTAATTTTATATTATCAAAGATGTATGAT
GAAAATTTACCGTATGATGTCGCTTTAAAACAGGCACAAGAGTTGGGATTTGCAGAAGTTAATCCAGATGCAGATGTTTT
AGGATATGATAGTGCTAGAAAGTTATCTATATTGTCTACTTTATCTTATGGAAAAATAGTATATTGGAAAGATTTATTAT
TAGAAGGAATAACTTCAATAGATGAAAAAGATATAGAATATGCAAAAAAATTAAATTGTAAGATAAAATTGGTTGCTAGA
AGTAAGTATGAATCAGGAGAAGTAAGTGGATTTGTTAGACCAGCATTAGTGGACAATAATAATATGCTTTCAAAGATAGA
TAATGAGTTCAACGTAGTTATTTTAGTAGGTGATTCAGTAGGTGAACTTTCTTTTGTAGGTAAGGGAGCTGGAAGAGGTG
CAACAGGAAGTGCTGTTTATGCAGATATTATAGATATAATAGATAATAGAAGTTCAAATATAAAGTCTTTTTCAAAAGGG
AAATTGGATTTAAGTGGACTTATAGAAGATGAGTGTAGTGCAGTAGTTAGATTTGGTGGGTATAATAATAAAGATGGAAT
TTTAGAATGTTTAGATAAATATGTAGATAGTTATGATATTATAGATGATGAAGAATTGGCGATTTTTGTAAGTGCAAAGT
CAGAACATGAGATTGATAGAGTTTTGGAAATTGTAAAAAGAAATAATTACAGTGAATCAGTTAAAAAATTATTGAAGATA
GATTAA

Upstream 100 bases:

>100_bases
AACCCGTCATATGGCTTGAGTTTATACTCAAGCTTTTTTTATTGGTATATTTATATATATAAATAATTTAATATAATCAA
AATGATGGGGGTATGTTACA

Downstream 100 bases:

>100_bases
TATGTTTATGCAAGAATTATGAAAATTTAATAGGGTGTCTCAAAATAGAGAGATAAGCCTTTTTTCCAGTGTTGAAATAA
TAAAAATATATTTGATTTTA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYKKYFDKITTDIEDIFDKDIDILVEVIGGLNPAFDYVT
RALNKKIHVVTANKDLLAEKGSDLIELANLNNVSIKFEASVAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYD
ENLPYDVALKQAQELGFAEVNPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGITSIDEKDIEYAKKLNCKIKLVAR
SKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILVGDSVGELSFVGKGAGRGATGSAVYADIIDIIDNRSSNIKSFSKG
KLDLSGLIEDECSAVVRFGGYNNKDGILECLDKYVDSYDIIDDEELAIFVSAKSEHEIDRVLEIVKRNNYSESVKKLLKI
D

Sequences:

>Translated_401_residues
MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYKKYFDKITTDIEDIFDKDIDILVEVIGGLNPAFDYVT
RALNKKIHVVTANKDLLAEKGSDLIELANLNNVSIKFEASVAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYD
ENLPYDVALKQAQELGFAEVNPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGITSIDEKDIEYAKKLNCKIKLVAR
SKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILVGDSVGELSFVGKGAGRGATGSAVYADIIDIIDNRSSNIKSFSKG
KLDLSGLIEDECSAVVRFGGYNNKDGILECLDKYVDSYDIIDDEELAIFVSAKSEHEIDRVLEIVKRNNYSESVKKLLKI
D
>Mature_401_residues
MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYKKYFDKITTDIEDIFDKDIDILVEVIGGLNPAFDYVT
RALNKKIHVVTANKDLLAEKGSDLIELANLNNVSIKFEASVAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYD
ENLPYDVALKQAQELGFAEVNPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGITSIDEKDIEYAKKLNCKIKLVAR
SKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILVGDSVGELSFVGKGAGRGATGSAVYADIIDIIDNRSSNIKSFSKG
KLDLSGLIEDECSAVVRFGGYNNKDGILECLDKYVDSYDIIDDEELAIFVSAKSEHEIDRVLEIVKRNNYSESVKKLLKI
D

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44199; Mature: 44199

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYKKYFDKITTDIEDIFDK
CEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
DIDILVEVIGGLNPAFDYVTRALNKKIHVVTANKDLLAEKGSDLIELANLNNVSIKFEAS
HHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCHHHHHCCCCEEEEECCCCEEEEEEEE
VAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYDENLPYDVALKQAQELGFAEV
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEC
NPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGITSIDEKDIEYAKKLNCKIKLVAR
CCCCCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEE
SKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILVGDSVGELSFVGKGAGRGATGSAVY
CCCCCCCCCCEECEEEECCCCHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCHHH
ADIIDIIDNRSSNIKSFSKGKLDLSGLIEDECSAVVRFGGYNNKDGILECLDKYVDSYDI
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCCC
IDDEELAIFVSAKSEHEIDRVLEIVKRNNYSESVKKLLKID
CCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYKKYFDKITTDIEDIFDK
CEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
DIDILVEVIGGLNPAFDYVTRALNKKIHVVTANKDLLAEKGSDLIELANLNNVSIKFEAS
HHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCHHHHHCCCCEEEEECCCCEEEEEEEE
VAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYDENLPYDVALKQAQELGFAEV
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEC
NPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGITSIDEKDIEYAKKLNCKIKLVAR
CCCCCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEE
SKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILVGDSVGELSFVGKGAGRGATGSAVY
CCCCCCCCCCEECEEEECCCCHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCHHH
ADIIDIIDNRSSNIKSFSKGKLDLSGLIEDECSAVVRFGGYNNKDGILECLDKYVDSYDI
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCCC
IDDEELAIFVSAKSEHEIDRVLEIVKRNNYSESVKKLLKID
CCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]