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The map label for this gene is malH [H]

Identifier: 126698441

GI number: 126698441

Start: 1040194

End: 1041522

Strand: Direct

Name: malH [H]

Synonym: CD0864

Alternate gene names: 126698441

Gene position: 1040194-1041522 (Clockwise)

Preceding gene: 126698440

Following gene: 126698442

Centisome position: 24.25

GC content: 31.15

Gene sequence:

>1329_bases
ATGGAAAAATTTTCAGTAGTAATAGCTGGAGGAGGAAGTACATATACCCCAGAAATCATATTAATGTTGCTAGATAACTT
AGATAGGTTACCATTAAGAGCAATCAAATTATATGATAATGATGAAGAAAGACAAAATAAGGTAGCTAAAGCTTGTGAAA
TACTAATAAAGGAAAAGGACCCTAATATAGAGTATTTAGCAACAACATGCCCTAAAGAGGCTTATACAGATGTAGATTTT
TGTTTAGCTCATATAAGAGTTGGAAAACTTGAAATGAGAGAACTAGATGAAAAGATACCTCTAAAACATGGAGTAGTTGG
TCAAGAAACTTGTGGACCAGGTGGAATAGCTTATGGAATGAGGTCTATAGAAGGTGTTCTTGAAAACATAGATTATATGG
AAAAGTATTCTCCAAATTGTTGGATGTTAAATTATTCTAATCCAGCATCAATAATAGCGGAAGCTGTTAGAAGGTTGAGA
CCTAATTCTAGGGTAATAAATATTTGTGATATGCCAATAGGTATGGAACATAATATAGCAAGGATTGCAGGACTCAAATC
TCGTAAACATATGGATATAAGATACTTTGGATTAAATCACTTTGGTTGGTATACTTCAATTAAAGATAAAAAAGGAAATG
AACTTTTACCAAAATTAGTAGAACATATAAAAGAATATGGTTTTATAAATGGTGAAGAAGGAATGAAAAATGACAAGAAA
GATAGTTGGTTTGAAACTAATTTATTTACTAAAGAAATAGTAAAAACAGATTTAACTACAATACCAAGTAGTTACTTAAA
GTACTATCTATTTCCAGATTATGTTGTAAATCATTCTGATGTAAATTATACTCGTGCCAATGAAGTTATTGATGGAAGAG
AAAAAGAAGTTTTTGGTTCATGTGCATTGATAGAAAAGCAAGGACATTCTAAGGGCAGTGGGCTTAAGATAGGAATACAT
GCAGAGTTTATAGTGGATTTAGCTACAGCTCTGGCTTTTAATACACAGGAGCGTATGTTATTGATAGTTCAAAATAATGG
AGCTATAGAAAATATACAAGATGATGCTATGGTTGAAATTCCATGTATAGTTGGAAAAGACGGGTATGAACCATTATCAA
TAGGGAAAATACCAACATTCCAAAAAGGTTTAATAGAACAACAATTAGCAGTTGAAAAATTAGTAGTTGATGCTTGGATT
GAGAAGTCTTATAATAAATTGTGGCAAGCACTTATGCTATCTAAGACAGTTCCTAGTGCAACAGTTGCAAAAGAATTACT
AGATGATTTAATAGAAGCAAATAAAAATTATTGGCCAAAACTTAATTAA

Upstream 100 bases:

>100_bases
ATAGATTTAATAAATGAACTCCCTTTTACTTTAAAGTACTAGTATTTATAAATATATTTATAAATACAGTAAATTTTTAA
ATAGAAAAGGAGATATTATT

Downstream 100 bases:

>100_bases
GAATAATATATTTTTAAAGTTCCTACAGTTTAGTACATAGCCTAGTTAATGTATTTGTAGGGACTTTATTTATCTACAAA
TGAGATACAAGTGGCAAACA

Product: 6-phospho-alpha-glucosidase

Products: NA

Alternate protein names: 6-phospho-alpha-glucosidase; 6-phospho-glucosidase; Maltose-6-phosphate hydrolase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEERQNKVAKACEILIKEKDPNIEYLATTCPKEAYTDVDF
CLAHIRVGKLEMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLR
PNSRVINICDMPIGMEHNIARIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPKLVEHIKEYGFINGEEGMKNDKK
DSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVVNHSDVNYTRANEVIDGREKEVFGSCALIEKQGHSKGSGLKIGIH
AEFIVDLATALAFNTQERMLLIVQNNGAIENIQDDAMVEIPCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVEKLVVDAWI
EKSYNKLWQALMLSKTVPSATVAKELLDDLIEANKNYWPKLN

Sequences:

>Translated_442_residues
MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEERQNKVAKACEILIKEKDPNIEYLATTCPKEAYTDVDF
CLAHIRVGKLEMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLR
PNSRVINICDMPIGMEHNIARIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPKLVEHIKEYGFINGEEGMKNDKK
DSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVVNHSDVNYTRANEVIDGREKEVFGSCALIEKQGHSKGSGLKIGIH
AEFIVDLATALAFNTQERMLLIVQNNGAIENIQDDAMVEIPCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVEKLVVDAWI
EKSYNKLWQALMLSKTVPSATVAKELLDDLIEANKNYWPKLN
>Mature_442_residues
MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEERQNKVAKACEILIKEKDPNIEYLATTCPKEAYTDVDF
CLAHIRVGKLEMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLR
PNSRVINICDMPIGMEHNIARIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPKLVEHIKEYGFINGEEGMKNDKK
DSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVVNHSDVNYTRANEVIDGREKEVFGSCALIEKQGHSKGSGLKIGIH
AEFIVDLATALAFNTQERMLLIVQNNGAIENIQDDAMVEIPCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVEKLVVDAWI
EKSYNKLWQALMLSKTVPSATVAKELLDDLIEANKNYWPKLN

Specific function: Catalyzes the hydrolysis of O-alpha-linked disaccharide 6-phosphates, including maltose-6'P and all five phosphorylated isomers of sucrose, but not sucrose-6P. Does not hydrolyze beta- linked disaccharide 6-phosphates such as cellobiose-6'P and gentiobios

COG id: COG1486

COG function: function code G; Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 4 family [H]

Homologues:

Organism=Escherichia coli, GI1788029, Length=455, Percent_Identity=29.010989010989, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790560, Length=453, Percent_Identity=22.7373068432671, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019802
- InterPro:   IPR001088
- InterPro:   IPR022616
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02056 Glyco_hydro_4; PF11975 Glyco_hydro_4C [H]

EC number: =3.2.1.122 [H]

Molecular weight: Translated: 50079; Mature: 50079

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEERQNKVAKACEILIKEKD
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
PNIEYLATTCPKEAYTDVDFCLAHIRVGKLEMRELDEKIPLKHGVVGQETCGPGGIAYGM
CCEEEEEECCCHHHHCCHHHHHHHHHCCCHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHH
RSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLRPNSRVINICDMPIGMEHNIA
HHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHH
RIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPKLVEHIKEYGFINGEEGMKNDKK
HHHCCCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
DSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVVNHSDVNYTRANEVIDGREKEVFGS
CCCCHHHHHHHHHHHHHHHHCCHHHHHEEECCCCEECCCCCCEEHHHHHHCCCCHHHHHC
CALIEKQGHSKGSGLKIGIHAEFIVDLATALAFNTQERMLLIVQNNGAIENIQDDAMVEI
EEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEE
PCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVEKLVVDAWIEKSYNKLWQALMLSKTVPSA
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TVAKELLDDLIEANKNYWPKLN
HHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEERQNKVAKACEILIKEKD
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
PNIEYLATTCPKEAYTDVDFCLAHIRVGKLEMRELDEKIPLKHGVVGQETCGPGGIAYGM
CCEEEEEECCCHHHHCCHHHHHHHHHCCCHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHH
RSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLRPNSRVINICDMPIGMEHNIA
HHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHH
RIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPKLVEHIKEYGFINGEEGMKNDKK
HHHCCCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
DSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVVNHSDVNYTRANEVIDGREKEVFGS
CCCCHHHHHHHHHHHHHHHHCCHHHHHEEECCCCEECCCCCCEEHHHHHHCCCCHHHHHC
CALIEKQGHSKGSGLKIGIHAEFIVDLATALAFNTQERMLLIVQNNGAIENIQDDAMVEI
EEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEE
PCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVEKLVVDAWIEKSYNKLWQALMLSKTVPSA
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TVAKELLDDLIEANKNYWPKLN
HHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11781805; 11466286 [H]