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The map label for this gene is glpK1 [H]

Identifier: 126698321

GI number: 126698321

Start: 903936

End: 905462

Strand: Direct

Name: glpK1 [H]

Synonym: CD0741

Alternate gene names: 126698321

Gene position: 903936-905462 (Clockwise)

Preceding gene: 126698319

Following gene: 126698322

Centisome position: 21.07

GC content: 33.2

Gene sequence:

>1527_bases
GTGAAATATGTATTAGCAATTGACCAAGGAACAACAGGAACAAGAGCAGTATTGATAAACGAAAAATCAGAGTTTGTTTT
TAGCGATTATATGGAACATACTCAAATATATCCACAATCTGGATATGTTGAACATGACCCTATAGAAATTTGGAATAATA
CAAAAACTGTGAGTAATAATGTATTACAACAAGCTTTTGAAAATGGAATCAATGAAAGTGATATAAAAGGAATTGGTATA
GATAATCAAGGTGAAACAGTAATGTTATGGGATAAAAATACAGGTAAACCACTTTACAATGCTATTGTGTGGCAGTGCAG
GAGAACTTATGATTATGTGGAAAATTTAAAGAATATACCAGGTTTAGAAAATAAGATAATAGATAAGACTGGGTTAATTA
TAGACCCATATTTCTCAGGTACAAAAATTAAATGGGTAATAGATAATGTAAAAGGTGTAAAAGAAAAAATTAAAAATGGA
GAAGTACTTGCAGGAACATTAGATAGTTGGTTAATATGGAAAATGACAGGAGGAAAATCTTTTTTAACTGATGTATCTAC
AGCAGCAAGAACAATGCTTTTTAATATAAGAGATATGGATTGGGATAGAGAGTTGCTTGACATTATAGGAGTACCTAGAA
GTATTTTAGCAGATATAATGCCTACGAGTGGTGATTTTGGAACTACAGATAAGGAGGCATTTTGTGGGGTTTCTATAAAA
ATTACTGCTTCAATGGTAGACCAACCAGCAGCTTTATTTGGCAATGGATGTTTTGAACCAGGAATGGTTAAAAATACTTA
TGGTACAGGATGTTTCCTATATATGAATATAGGTGAGGAACTAAATATAGCAGGTAATGGTATTTTGACAACTGTTGCTT
GGAAAATAGGAGATAAGGTTACATATGCTTATGATGGTGGAGTGTATATAGCAGGTGCTGCAATACAATGGCTTAGAGAT
GGCATTGGAGTTATAAAAAATTATTCAGAAACTGATGACATGGCAAATTCCATATCAAGTACTGGAGGTGTATATTTTGT
ACCAGCATTTGCAGGTATAGCAGCACCTTATTGGGACCAATATGCTAGAGGTACAATGGTTGGGATAACAGGAAGTACTA
AAAAAGAGCATATAGTAAGAGCGACTCTTGAGTCTGTTGCACTTCAAGTCAAAGATGTTGTTGATTCTATGAACTTAGCC
TCAGGGAAAAAAATAAAAATGTTGAGAGTAGATGGTGGAATTACTAAAAATAACTTTACAATGCAATTTCAATCCGACAT
ATTAGGCATACCAATTGAAATTGCAGAAAATCCTGAGACGACAGTACTTGGAGTAGGATATATGGCAGGTCTTTCTTGTG
GTGTCTGGAACAGTATTGATGAAATTAGAAGTGAATTTACAATAAGCAAAAAATATATTCCAAATATGACTACTCAAAAA
AGAGAAGAAATATTACTTGGATGGAACCAAGCAGTAAAAAGAGCTATGAATTGGGAAAACGATACCAAAAAGGTGTGTGC
TAATTAA

Upstream 100 bases:

>100_bases
ATCCACATGATGATATAAAATATAAATAACTTGAATAGATTATATATTCAAAAAATAAAAAAGAATTTATTAATTCTGAA
AATAAAGGGGGACATTTAAA

Downstream 100 bases:

>100_bases
GTTACAATAGAGTATTTTACATGTATAGGAGGAATTAAAAATGCCCTTTGATAAAATTATATTATACATAATGGCTGTGG
GAGTGCTTTTAGGAGCGTTA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVEHDPIEIWNNTKTVSNNVLQQAFENGINESDIKGIGI
DNQGETVMLWDKNTGKPLYNAIVWQCRRTYDYVENLKNIPGLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNG
EVLAGTLDSWLIWKMTGGKSFLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILADIMPTSGDFGTTDKEAFCGVSIK
ITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMNIGEELNIAGNGILTTVAWKIGDKVTYAYDGGVYIAGAAIQWLRD
GIGVIKNYSETDDMANSISSTGGVYFVPAFAGIAAPYWDQYARGTMVGITGSTKKEHIVRATLESVALQVKDVVDSMNLA
SGKKIKMLRVDGGITKNNFTMQFQSDILGIPIEIAENPETTVLGVGYMAGLSCGVWNSIDEIRSEFTISKKYIPNMTTQK
REEILLGWNQAVKRAMNWENDTKKVCAN

Sequences:

>Translated_508_residues
MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVEHDPIEIWNNTKTVSNNVLQQAFENGINESDIKGIGI
DNQGETVMLWDKNTGKPLYNAIVWQCRRTYDYVENLKNIPGLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNG
EVLAGTLDSWLIWKMTGGKSFLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILADIMPTSGDFGTTDKEAFCGVSIK
ITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMNIGEELNIAGNGILTTVAWKIGDKVTYAYDGGVYIAGAAIQWLRD
GIGVIKNYSETDDMANSISSTGGVYFVPAFAGIAAPYWDQYARGTMVGITGSTKKEHIVRATLESVALQVKDVVDSMNLA
SGKKIKMLRVDGGITKNNFTMQFQSDILGIPIEIAENPETTVLGVGYMAGLSCGVWNSIDEIRSEFTISKKYIPNMTTQK
REEILLGWNQAVKRAMNWENDTKKVCAN
>Mature_508_residues
MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVEHDPIEIWNNTKTVSNNVLQQAFENGINESDIKGIGI
DNQGETVMLWDKNTGKPLYNAIVWQCRRTYDYVENLKNIPGLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNG
EVLAGTLDSWLIWKMTGGKSFLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILADIMPTSGDFGTTDKEAFCGVSIK
ITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMNIGEELNIAGNGILTTVAWKIGDKVTYAYDGGVYIAGAAIQWLRD
GIGVIKNYSETDDMANSISSTGGVYFVPAFAGIAAPYWDQYARGTMVGITGSTKKEHIVRATLESVALQVKDVVDSMNLA
SGKKIKMLRVDGGITKNNFTMQFQSDILGIPIEIAENPETTVLGVGYMAGLSCGVWNSIDEIRSEFTISKKYIPNMTTQK
REEILLGWNQAVKRAMNWENDTKKVCAN

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=42.6294820717131, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4504007, Length=502, Percent_Identity=42.6294820717131, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI42794763, Length=506, Percent_Identity=41.897233201581, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI41393575, Length=502, Percent_Identity=41.0358565737052, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI88196792, Length=518, Percent_Identity=32.8185328185328, Blast_Score=292, Evalue=7e-79,
Organism=Escherichia coli, GI1790361, Length=498, Percent_Identity=48.5943775100402, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1789168, Length=498, Percent_Identity=21.8875502008032, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789987, Length=482, Percent_Identity=22.1991701244813, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=507, Percent_Identity=36.6863905325444, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI71986140, Length=524, Percent_Identity=25.5725190839695, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71986147, Length=300, Percent_Identity=29.6666666666667, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321755, Length=557, Percent_Identity=29.6229802513465, Blast_Score=252, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17864214, Length=510, Percent_Identity=39.2156862745098, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655555, Length=511, Percent_Identity=36.7906066536204, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655560, Length=511, Percent_Identity=36.7906066536204, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655570, Length=511, Percent_Identity=36.7906066536204, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655574, Length=511, Percent_Identity=36.7906066536204, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655565, Length=511, Percent_Identity=36.7906066536204, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24654573, Length=438, Percent_Identity=41.324200913242, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI19922058, Length=529, Percent_Identity=31.0018903591682, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24652871, Length=499, Percent_Identity=31.6633266533066, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI21357867, Length=531, Percent_Identity=26.7419962335217, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24656367, Length=520, Percent_Identity=27.6923076923077, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24656372, Length=376, Percent_Identity=27.9255319148936, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45552909, Length=329, Percent_Identity=27.9635258358663, Blast_Score=138, Evalue=1e-32,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 56218; Mature: 56218

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVEHDPIEIWNNTKTVSNN
CEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHEECCCCCCCCCCCEEEECCCCHHHHH
VLQQAFENGINESDIKGIGIDNQGETVMLWDKNTGKPLYNAIVWQCRRTYDYVENLKNIP
HHHHHHHCCCCCCCCCEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNGEVLAGTLDSWLIWKMTGGKS
CCCHHHHCCCCCEEECCCCCCEEEEEECCHHHHHHHHCCCCEEEEECCCEEEEEEECCCH
FLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILADIMPTSGDFGTTDKEAFCGVSIK
HHHHHHHHHHHHEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHCCEEEE
ITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMNIGEELNIAGNGILTTVAWKIGDKV
EEEHHHCCCHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCEEEEEEEECCCEE
TYAYDGGVYIAGAAIQWLRDGIGVIKNYSETDDMANSISSTGGVYFVPAFAGIAAPYWDQ
EEEECCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHCCHHHHH
YARGTMVGITGSTKKEHIVRATLESVALQVKDVVDSMNLASGKKIKMLRVDGGITKNNFT
HHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEECCCEE
MQFQSDILGIPIEIAENPETTVLGVGYMAGLSCGVWNSIDEIRSEFTISKKYIPNMTTQK
EEEECCCCCCEEEECCCCCCEEEECHHHHCCCCCCCCCHHHHHHHHEECHHHCCCCCHHH
REEILLGWNQAVKRAMNWENDTKKVCAN
HHHHHCCHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVEHDPIEIWNNTKTVSNN
CEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHEECCCCCCCCCCCEEEECCCCHHHHH
VLQQAFENGINESDIKGIGIDNQGETVMLWDKNTGKPLYNAIVWQCRRTYDYVENLKNIP
HHHHHHHCCCCCCCCCEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNGEVLAGTLDSWLIWKMTGGKS
CCCHHHHCCCCCEEECCCCCCEEEEEECCHHHHHHHHCCCCEEEEECCCEEEEEEECCCH
FLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILADIMPTSGDFGTTDKEAFCGVSIK
HHHHHHHHHHHHEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHCCEEEE
ITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMNIGEELNIAGNGILTTVAWKIGDKV
EEEHHHCCCHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCEEEEEEEECCCEE
TYAYDGGVYIAGAAIQWLRDGIGVIKNYSETDDMANSISSTGGVYFVPAFAGIAAPYWDQ
EEEECCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHCCHHHHH
YARGTMVGITGSTKKEHIVRATLESVALQVKDVVDSMNLASGKKIKMLRVDGGITKNNFT
HHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEECCCEE
MQFQSDILGIPIEIAENPETTVLGVGYMAGLSCGVWNSIDEIRSEFTISKKYIPNMTTQK
EEEECCCCCCEEEECCCCCCEEEECHHHHCCCCCCCCCHHHHHHHHEECHHHCCCCCHHH
REEILLGWNQAVKRAMNWENDTKKVCAN
HHHHHCCHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]