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The map label for this gene is spaR [H]

Identifier: 126698058

GI number: 126698058

Start: 569476

End: 570168

Strand: Direct

Name: spaR [H]

Synonym: CD0481

Alternate gene names: 126698058

Gene position: 569476-570168 (Clockwise)

Preceding gene: 126698057

Following gene: 126698059

Centisome position: 13.27

GC content: 35.06

Gene sequence:

>693_bases
TTGAGTAAAATATTGATTATTGATGATGAAATGGACCTAGTAATGCTACTTGAGGATGAATTGAAGGCAAAAGGACATGA
AGTGTTGATAGCTTATGATGGTCAGGCAGGTATAGAGTTATCAAAACAGGAGCCTGACCTTATTATACTGGATATTATGA
TGCCTAAAATGAATGGATTTGAGGTATGTCAGGCAATTAGAGATGATGTTTTATGCCCAATTATATTTTTAAGTGCAAAG
CAATCAGAAACCGACAAAATCAAAGGGTTGACCTTTGGAGGGGATGATTATGTAACAAAGCCATTTGGACTGCGTGAACT
TATGGCAAGGATTGAAGCTAATCTGCGTAGGGAAAAGCGTTCACAGTATATCAATGAAGAGAACAAGAGATCTACTTTGT
ATTTTGGGAAGTTATGCTTATATATGAAGGAACGTGCAATTAAAATTGATGGTAAGAATATTGATTTAACAAAAATAGAG
TATGATATTGTTGAATTACTAGCACTCCATGCAGGACAAGTTTTCTCAAGAGAACAAATCTATGAAAAAGTATGGGGGTG
TGATTCTGAAGGTGATTCCTCAACTGTTGTTGAACGAGTAAAAAAAATACGAGCTAAGTTTTCTGCTGTGACACCAGAAA
AAGAATATATTTCCACAGTTTGGGGTATTGGGTATAAGTGGAATAAAATGTAA

Upstream 100 bases:

>100_bases
AGGCGTTATTTGGTTTAAAATGTGGGAGGGAAGGAAAAGTTATTAGTAGACGAATATTGTTTTAATACTGACCTTCCCAT
AAGAGAAAGGTGGTGTTATA

Downstream 100 bases:

>100_bases
AGAGAGAGAGGTTATTAAATGAAAAATCAATCCCTTATTACCCAATTTAGACATACTTTTATTTTTATTATAATAGCCAG
TATAGTTGCCACAGTGATTA

Product: lantibiotic resistance two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQEPDLIILDIMMPKMNGFEVCQAIRDDVLCPIIFLSAK
QSETDKIKGLTFGGDDYVTKPFGLRELMARIEANLRREKRSQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIE
YDIVELLALHAGQVFSREQIYEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYISTVWGIGYKWNKM

Sequences:

>Translated_230_residues
MSKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQEPDLIILDIMMPKMNGFEVCQAIRDDVLCPIIFLSAK
QSETDKIKGLTFGGDDYVTKPFGLRELMARIEANLRREKRSQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIE
YDIVELLALHAGQVFSREQIYEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYISTVWGIGYKWNKM
>Mature_229_residues
SKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQEPDLIILDIMMPKMNGFEVCQAIRDDVLCPIIFLSAKQ
SETDKIKGLTFGGDDYVTKPFGLRELMARIEANLRREKRSQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIEY
DIVELLALHAGQVFSREQIYEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYISTVWGIGYKWNKM

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=37.6106194690265, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.4801762114537, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=34.5132743362832, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=31.6964285714286, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=33.7777777777778, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.2775330396476, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=31.5555555555556, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=27.5862068965517, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=32.7510917030568, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.5309734513274, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=25.1082251082251, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=32.1100917431193, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26417; Mature: 26286

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQEPDLIILDIMMPKMNGF
CCEEEEEECCCCEEEEEEHHHCCCCCEEEEEECCCCCCEECCCCCCEEEEEEECCCCCHH
EVCQAIRDDVLCPIIFLSAKQSETDKIKGLTFGGDDYVTKPFGLRELMARIEANLRREKR
HHHHHHHHCCCCHHEEEECCCCCCHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
SQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIEYDIVELLALHAGQVFSREQI
HHHCCCCCCCHHHHHHHHHHHHHHCEEEECCCCCEEEEHHHHHHHHHHHHHCHHHHHHHH
YEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYISTVWGIGYKWNKM
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
SKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQEPDLIILDIMMPKMNGF
CEEEEEECCCCEEEEEEHHHCCCCCEEEEEECCCCCCEECCCCCCEEEEEEECCCCCHH
EVCQAIRDDVLCPIIFLSAKQSETDKIKGLTFGGDDYVTKPFGLRELMARIEANLRREKR
HHHHHHHHCCCCHHEEEECCCCCCHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
SQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIEYDIVELLALHAGQVFSREQI
HHHCCCCCCCHHHHHHHHHHHHHHCEEEECCCCCEEEEHHHHHHHHHHHHHCHHHHHHHH
YEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYISTVWGIGYKWNKM
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]