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The map label for this gene is purN [H]

Identifier: 126697793

GI number: 126697793

Start: 285346

End: 285939

Strand: Direct

Name: purN [H]

Synonym: CD0222

Alternate gene names: 126697793

Gene position: 285346-285939 (Clockwise)

Preceding gene: 126697792

Following gene: 126697794

Centisome position: 6.65

GC content: 31.82

Gene sequence:

>594_bases
ATGCTAAATATAGGAGTTTTAATATCTGGTGGGGGAACAAATTTACAAGCAGTTATAGATGGTACTGAGTCTGGAGAAAT
AAAAGGTCAGGTTAAAGTAGTTATCTCAAGTAAGCAAGGTGCTTATGGGCTAGAGAGAGCTAAAAATCATAACATAAAAG
CAATTTGTGAAACTGATGAAGACAAGATAATAGAAATTCTTAAGGAAAATAAAATAGATTTAGTAGTTTTGGCTGGTTAT
TTAAAAATAATCAGCCCAAAGCTGGTTAATGAGTTTAGAAACAAAATGATAAACATACATCCATCATTAATTCCTTCATT
TTGTGGAGCTGGATTCTATGGAGAAAAAGTTCATCAAGGTGTTATAGATTACGGAGCTAAAGTAACTGGTGCTACAGTTC
ATTTTGTTGATGAAGGTGCTGATACTGGACCAATCATAATGCAAGATGTAGTTAAGGTAAATCAAGATGATGATGCAAAG
ACACTTGCAAAAAGAGTGTTAGAAGTTGAACATAGGATTTTAAAAGAAAGTATAAGTCTTTTTTGTGAAAATAAATTAAA
ACTTCAAGGTAGGAGAGTGTTTATAAATGAGTAA

Upstream 100 bases:

>100_bases
ATGACAATGCTGATTATGTAGATAAAAAATATAGTGAATTATTAGAAGATAAAGCTTATATAATTGGTGAAGTAGTAGAT
AGTCATGAAGGTGTAGAATT

Downstream 100 bases:

>100_bases
GAGAGCTTTAATAAGTGTAACTGACAAGACTGGTGTAGTGGAATTTGCTAAAGAGTTAAATAAATTAGATTATGAAATTA
TATCTACAGGAAATACATTT

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGLERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGY
LKIISPKLVNEFRNKMINIHPSLIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK
TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE

Sequences:

>Translated_197_residues
MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGLERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGY
LKIISPKLVNEFRNKMINIHPSLIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK
TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE
>Mature_197_residues
MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGLERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGY
LKIISPKLVNEFRNKMINIHPSLIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK
TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=207, Percent_Identity=38.6473429951691, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI209869995, Length=207, Percent_Identity=38.6473429951691, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI209869993, Length=207, Percent_Identity=38.6473429951691, Blast_Score=135, Evalue=2e-32,
Organism=Escherichia coli, GI1788846, Length=204, Percent_Identity=36.2745098039216, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1787483, Length=136, Percent_Identity=34.5588235294118, Blast_Score=94, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17567511, Length=184, Percent_Identity=34.2391304347826, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320616, Length=198, Percent_Identity=29.7979797979798, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24582400, Length=189, Percent_Identity=37.5661375661376, Blast_Score=133, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 21599; Mature: 21599

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGLERAKNHNIKAICETDE
CEEEEEEEECCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHCCCCEEEEEECCH
DKIIEILKENKIDLVVLAGYLKIISPKLVNEFRNKMINIHPSLIPSFCGAGFYGEKVHQG
HHHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHEEECCHHHHHHHHCCCCCHHHHHHH
VIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAKTLAKRVLEVEHRILKESISL
HHHCCCEECCCEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FCENKLKLQGRRVFINE
HHCCCEEECCCEEEECC
>Mature Secondary Structure
MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGLERAKNHNIKAICETDE
CEEEEEEEECCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHCCCCEEEEEECCH
DKIIEILKENKIDLVVLAGYLKIISPKLVNEFRNKMINIHPSLIPSFCGAGFYGEKVHQG
HHHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHEEECCHHHHHHHHCCCCCHHHHHHH
VIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAKTLAKRVLEVEHRILKESISL
HHHCCCEECCCEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FCENKLKLQGRRVFINE
HHCCCEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]