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The map label for this gene is purH

Identifier: 126697794

GI number: 126697794

Start: 285932

End: 287464

Strand: Direct

Name: purH

Synonym: CD0223

Alternate gene names: 126697794

Gene position: 285932-287464 (Clockwise)

Preceding gene: 126697793

Following gene: 126697795

Centisome position: 6.66

GC content: 28.38

Gene sequence:

>1533_bases
ATGAGTAAGAGAGCTTTAATAAGTGTAACTGACAAGACTGGTGTAGTGGAATTTGCTAAAGAGTTAAATAAATTAGATTA
TGAAATTATATCTACAGGAAATACATTTAAAACATTAAAAGAAAATGGTGTTAATGTAATGCAAGTTGAAGATGTTACAA
ATTTTCCAGAAATATTAGATGGAAGAGTAAAAACATTAAATCCATATATACATGGTGGTATACTTTATAAAAGAGATAAA
GAATCTCATGTAGAAACTGTAAATGAACACAAAATACATTCAATAGATTTAGTAGCTGTAAATCTATATGATTTTGAAGG
AACTTTAAAAGCTGGAAAAAGTCATGATGAAATAATTGAAAATATAGATATTGGTGGACCATCTATGATACGTTCTGCTG
CCAAAAACTATAAGGATGTAATAGTAGTAGTAGATATAAAAGATTATGATTCTATAATAGAAAAATTAAAAACAGATACA
ATGACATTAGAAGACAGAAAAAAATTATCATATAAAGCTTTCTCAACTACAGGAAGATATGATGCGTTAATATCTAGTTA
TTTTGCTGGAGAAGTTGGAGATACGTATCCTGACATATTAAATTTAACTTTCCAAAAAGAACAAACTTTAAGATATGGAG
AAAATCCACATCAAAATGGTTTCTTATATTCACAGTCAAATGCAAAAAATCCAATCTTAAATTATGAGCAATTAGGCGGT
AAAGAACTTTCTTTTAACAACTTAAATGATTTACATGGATGTTTAGAAGTAATGAGAGAATTTAAAGATAGTGAAGAAGT
AGTTTCAGTAGCTATAAAACATGCTAATTCATGTGGGGTAGGTTTAGGAAAAGATGCTTTTGAAGCATATACAAAATGTT
ATGAAGCGGATAAGGTTTCAATATTTGGAGGAATAGTAGGAATAACTTCTACTATAGATAAAGCTACAGCAGAGAAATTA
AATGAAATATTCTTAGAAATAGTAGTAGCATATGATTTTGAACCAGAAGCTTTAGAGATACTTAAACAAAAGAAAAATCT
AAGAATATTAAAATTAGCTAAAATAGAAAATAGTTTACAACCATATGAAATGAAATATTTAGATGGAAAATTATTGATAC
AAGATAGAAACAATATATTAGCAGAAAAAAGTGAAAATGTAACAAAGGAAAAACCAACAGATGCACAACTTAAGGACATG
GAATTTGGTATGAGAGTAGTAAAAAATATGAAATCAAATGCAATTGCAATAGTAAAAAATGGACAAACTCTAGCTTTAGG
TTGTGGACAAACATCAAGAATTTGGGCATTAAAAAATGCTCTTGAAAATAACAAAGATAAAGATTTTACAGGAGCTGTTT
TAGCGTCAGACGCATTTTTCCCATTTGATGATTGTGTAACATTAGCTCATGAATATGGAATATCAGCAGTAGTTCAACCA
GGTGGCTCTATAAAAGATAAAGATTCAATAGAAGCTTGTGACAAGTATGATATGGTTATGGTATTTACAGGAATAAGACA
CTTCAAACACTAA

Upstream 100 bases:

>100_bases
GCAAAAAGAGTGTTAGAAGTTGAACATAGGATTTTAAAAGAAAGTATAAGTCTTTTTTGTGAAAATAAATTAAAACTTCA
AGGTAGGAGAGTGTTTATAA

Downstream 100 bases:

>100_bases
GGAGGATATTATGAAGATATTGGTTGTAGGCGGTGGCGGAAGAGAGCATGCTATATGCTGGAAACTAAGCAAAGAAAAAA
ATGTAGAAAAAATTTATTGT

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGVNVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDK
ESHVETVNEHKIHSIDLVAVNLYDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDT
MTLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQNGFLYSQSNAKNPILNYEQLGG
KELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHANSCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKL
NEIFLEIVVAYDFEPEALEILKQKKNLRILKLAKIENSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKEKPTDAQLKDM
EFGMRVVKNMKSNAIAIVKNGQTLALGCGQTSRIWALKNALENNKDKDFTGAVLASDAFFPFDDCVTLAHEYGISAVVQP
GGSIKDKDSIEACDKYDMVMVFTGIRHFKH

Sequences:

>Translated_510_residues
MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGVNVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDK
ESHVETVNEHKIHSIDLVAVNLYDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDT
MTLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQNGFLYSQSNAKNPILNYEQLGG
KELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHANSCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKL
NEIFLEIVVAYDFEPEALEILKQKKNLRILKLAKIENSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKEKPTDAQLKDM
EFGMRVVKNMKSNAIAIVKNGQTLALGCGQTSRIWALKNALENNKDKDFTGAVLASDAFFPFDDCVTLAHEYGISAVVQP
GGSIKDKDSIEACDKYDMVMVFTGIRHFKH
>Mature_509_residues
SKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGVNVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDKE
SHVETVNEHKIHSIDLVAVNLYDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDTM
TLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQNGFLYSQSNAKNPILNYEQLGGK
ELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHANSCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKLN
EIFLEIVVAYDFEPEALEILKQKKNLRILKLAKIENSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKEKPTDAQLKDME
FGMRVVKNMKSNAIAIVKNGQTLALGCGQTSRIWALKNALENNKDKDFTGAVLASDAFFPFDDCVTLAHEYGISAVVQPG
GSIKDKDSIEACDKYDMVMVFTGIRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=602, Percent_Identity=31.5614617940199, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1790439, Length=527, Percent_Identity=41.7457305502846, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71985564, Length=606, Percent_Identity=32.3432343234323, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71985574, Length=298, Percent_Identity=28.8590604026846, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71985556, Length=61, Percent_Identity=49.1803278688525, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323768, Length=464, Percent_Identity=31.8965517241379, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323056, Length=465, Percent_Identity=32.9032258064516, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24649832, Length=603, Percent_Identity=31.6749585406302, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_CLOD6 (Q18CW0)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086691.1
- ProteinModelPortal:   Q18CW0
- SMR:   Q18CW0
- STRING:   Q18CW0
- GeneID:   4916698
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0223
- NMPDR:   fig|1496.1.peg.1440
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   VILAHEY
- ProtClustDB:   PRK00881
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 57108; Mature: 56976

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGVNVMQVEDVTNFPEILD
CCCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHCCCEEEEECCCCCCHHHHC
GRVKTLNPYIHGGILYKRDKESHVETVNEHKIHSIDLVAVNLYDFEGTLKAGKSHDEIIE
CCCEECCCEEECCEEEECCCHHHHHHHHCCCCEEEEEEEEEEEECCCHHCCCCCHHHHHH
NIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDTMTLEDRKKLSYKAFSTTGRY
HCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCEEHHHHHHCCEEEECCCCHH
DALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQNGFLYSQSNAKNPILNYEQLGG
HHHHHHHHCCCCCCCCHHHHEEEECCHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHCCC
KELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHANSCGVGLGKDAFEAYTKCYEADKVS
CEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEE
IFGGIVGITSTIDKATAEKLNEIFLEIVVAYDFEPEALEILKQKKNLRILKLAKIENSLQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCEEEEEEHHHCCCC
PYEMKYLDGKLLIQDRNNILAEKSENVTKEKPTDAQLKDMEFGMRVVKNMKSNAIAIVKN
CEEEEECCCEEEEEECCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
GQTLALGCGQTSRIWALKNALENNKDKDFTGAVLASDAFFPFDDCVTLAHEYGISAVVQP
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEECC
GGSIKDKDSIEACDKYDMVMVFTGIRHFKH
CCCCCCCCHHHHCCCCCEEHEEHHHHHHCC
>Mature Secondary Structure 
SKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGVNVMQVEDVTNFPEILD
CCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHCCCEEEEECCCCCCHHHHC
GRVKTLNPYIHGGILYKRDKESHVETVNEHKIHSIDLVAVNLYDFEGTLKAGKSHDEIIE
CCCEECCCEEECCEEEECCCHHHHHHHHCCCCEEEEEEEEEEEECCCHHCCCCCHHHHHH
NIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDTMTLEDRKKLSYKAFSTTGRY
HCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCEEHHHHHHCCEEEECCCCHH
DALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQNGFLYSQSNAKNPILNYEQLGG
HHHHHHHHCCCCCCCCHHHHEEEECCHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHCCC
KELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHANSCGVGLGKDAFEAYTKCYEADKVS
CEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEE
IFGGIVGITSTIDKATAEKLNEIFLEIVVAYDFEPEALEILKQKKNLRILKLAKIENSLQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCEEEEEEHHHCCCC
PYEMKYLDGKLLIQDRNNILAEKSENVTKEKPTDAQLKDMEFGMRVVKNMKSNAIAIVKN
CEEEEECCCEEEEEECCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
GQTLALGCGQTSRIWALKNALENNKDKDFTGAVLASDAFFPFDDCVTLAHEYGISAVVQP
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEECC
GGSIKDKDSIEACDKYDMVMVFTGIRHFKH
CCCCCCCCHHHHCCCCCEEHEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA