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The map label for this gene is purG [H]

Identifier: 126697792

GI number: 126697792

Start: 284276

End: 285352

Strand: Direct

Name: purG [H]

Synonym: CD0221

Alternate gene names: 126697792

Gene position: 284276-285352 (Clockwise)

Preceding gene: 126697791

Following gene: 126697793

Centisome position: 6.63

GC content: 31.75

Gene sequence:

>1077_bases
ATGTTAACATATAAAGAATCAGGTGTAGATATAGATGAAGGAAATAGAGCAGTAGACCTTATAAAAGGTAAAATAAAAGG
AACTTATGATGGAAATGTAGTTGGAGATTTAGGTAACTTCAGTGGATTATACAGTTTAAAAGATTTTGTAGGTATGAAAG
AACCAGTTTTGCTTGCATCTACAGATGGTGTTGGGACTAAGTTAAAAATAGCTCAGATGATGGACAAGCATGATACTGTT
GGAATAGATTTAGTTGCAATGTGCGTGAATGATTTAATTTGTCAAGGAGCAAAACCATTATTCTTCCTTGACTATATAGC
TCTTGGGAAATTAGTGCCTGAGCATATCGAAAAAATAGTTGGTGGAATTGCAGATGGTTGTAAAATGTCTGGTTGTGCAC
TAATTGGTGGAGAAACTGCTGAAATGCCTGGAATGTATGGAGAAGATGACTATGATTTAGCAGGATTTTCTGTAGGAATA
GCAGACAAAGAAAAGATTGTTTCTGGAAACAATGTTAAATCAGGAGATGTATTGGTTGGTATATCTTCAAGTGGAGTACA
CAGCAATGGATTTTCTTTTATAAGAAAGATATTTTTAGAAACTTACAATTATAAAATGGAACAATATGTTGAAGAACTAG
GAATGACAGTTGGAGAAGCACTTTTAACACCAACTAAAATATATGTTAAATTAGCTTTAGATGTATTAGCTAAACATGAC
ATAAAAGCTATAGCTCACATAACTGGTGGAGGGCTTATAGAAAATATAACAAGAGTTATACCTAAAGGGTTAGGACTAGA
TATCAATAAAAAATCTTGGGAGAAGCCTCCTATATTTAAAATGATAGAAGGTTTTAATGCTGTTGATGAGAGAGAACTTC
ATAAGAGTTTTAACATGGGTATTGGGCTAGTTTTAATAGTAGATAAAGAAAATGCTGATGATGTTGTAAACTTTATAAAT
AATAGAGAAAATGACAATGCTGATTATGTAGATAAAAAATATAGTGAATTATTAGAAGATAAAGCTTATATAATTGGTGA
AGTAGTAGATAGTCATGAAGGTGTAGAATTATGCTAA

Upstream 100 bases:

>100_bases
AAGGAATGTTAGATGCAACAGAACATAAGTCTACTTTCTGTAAAGCTTGTTTTGATGGAGAATACCCAGTTAAGAAAATT
GATAAGGAGGAACTACTTTC

Downstream 100 bases:

>100_bases
ATATAGGAGTTTTAATATCTGGTGGGGGAACAAATTTACAAGCAGTTATAGATGGTACTGAGTCTGGAGAAATAAAAGGT
CAGGTTAAAGTAGTTATCTC

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLYSLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTV
GIDLVAMCVNDLICQGAKPLFFLDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI
ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVGEALLTPTKIYVKLALDVLAKHD
IKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKPPIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFIN
NRENDNADYVDKKYSELLEDKAYIIGEVVDSHEGVELC

Sequences:

>Translated_358_residues
MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLYSLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTV
GIDLVAMCVNDLICQGAKPLFFLDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI
ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVGEALLTPTKIYVKLALDVLAKHD
IKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKPPIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFIN
NRENDNADYVDKKYSELLEDKAYIIGEVVDSHEGVELC
>Mature_358_residues
MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLYSLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTV
GIDLVAMCVNDLICQGAKPLFFLDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI
ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVGEALLTPTKIYVKLALDVLAKHD
IKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKPPIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFIN
NRENDNADYVDKKYSELLEDKAYIIGEVVDSHEGVELC

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=355, Percent_Identity=47.3239436619718, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI209869995, Length=355, Percent_Identity=47.3239436619718, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI209869993, Length=355, Percent_Identity=47.3239436619718, Blast_Score=318, Evalue=4e-87,
Organism=Escherichia coli, GI1788845, Length=324, Percent_Identity=48.7654320987654, Blast_Score=310, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17567511, Length=359, Percent_Identity=39.2757660167131, Blast_Score=220, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=319, Percent_Identity=46.3949843260188, Blast_Score=273, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24582400, Length=268, Percent_Identity=42.910447761194, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38918; Mature: 38918

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLYSLKDFVGMKEPVLLAS
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCEEEEE
TDGVGTKLKIAQMMDKHDTVGIDLVAMCVNDLICQGAKPLFFLDYIALGKLVPEHIEKIV
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGIADKEKIVSGNNVKSGDVLVG
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCCCCEEEE
ISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVGEALLTPTKIYVKLALDVLAKHD
ECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKPPIFKMIEGFNAVDERELHKSFNMG
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCC
IGLVLIVDKENADDVVNFINNRENDNADYVDKKYSELLEDKAYIIGEVVDSHEGVELC
EEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLYSLKDFVGMKEPVLLAS
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCEEEEE
TDGVGTKLKIAQMMDKHDTVGIDLVAMCVNDLICQGAKPLFFLDYIALGKLVPEHIEKIV
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGIADKEKIVSGNNVKSGDVLVG
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCCCCEEEE
ISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVGEALLTPTKIYVKLALDVLAKHD
ECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKPPIFKMIEGFNAVDERELHKSFNMG
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCC
IGLVLIVDKENADDVVNFINNRENDNADYVDKKYSELLEDKAYIIGEVVDSHEGVELC
EEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA