Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 126697767

GI number: 126697767

Start: 252260

End: 253888

Strand: Direct

Name: groEL

Synonym: CD0194

Alternate gene names: 126697767

Gene position: 252260-253888 (Clockwise)

Preceding gene: 126697766

Following gene: 126697768

Centisome position: 5.88

GC content: 33.27

Gene sequence:

>1629_bases
ATGGCTAAAGAAATTAAATTTTCAGAGGAAACAAGAAGAGCTTTAGAAGCTGGTGTAAATAAATTAGCAGATACAGTAAA
AGTAACATTAGGACCTAAAGGAAGAAATGTTATATTAGATAAAAAATTTGGTTCTCCACTTATAACTAATGATGGAGTAA
CTATAGCAAAAGAGATAGAACTAGAAGATAGATTTGAAAATATGGGTGCTCAATTAGTTAAAGAAGTAGCAACTAAAACT
AATGATGTAGCTGGAGATGGTACTACAACTGCTACAGTTTTAGCACAAGCTATAATAAGAGAAGGTTTAAAGAATGTAAC
AGCAGGGGCTAACCCAATACTTTTAAGAAAAGGAATACAAAAAGCAGTAACAGTAGCAGTAGAAGAATTAAAAAATCAAT
CAAGAATAGTAGAAACACAAGAGGCTATATCTCAAGTTGCTTCTATATCTGCTGGTGATGAAGAAGTTGGAAAATTAATA
GCAGAAGCTATGGAAATAGTAGGTAAAGATGGAGTTATAACTGTTGAAGAGTCTCAAACTATGAATACTGAATTAGATGC
TGTTGAAGGTATGCAGTTTGATAGAGGATTTGTTTCTGCATATATGGTTACAGATGTAGATAAAATGGAAGCAGTTTTAA
ATGACCCATATATATTAATTACTGATAAAAAAATATCTAACATACAAGAATTATTACCAGTTCTTGAACAAATAGTTCAA
CAAGGTAAAAAGCTATTGATAATAGCTGAAGATGTAGAAGGTGAAGCATTATCTACATTAGTAGTAAATAAATTAAGAGG
AACATTTGATGTAGTAGCAGTTAAAGCTCCAGGCTTTGGAGATAGAAGAAAAGAAATGCTTCAAGATATAGCAATACTTA
CAGGTGCTCAAGTAATATCAGAAGAATTAGGTTATGATTTAAAAGAAGCTGATTTATCTATGCTAGGTAGAGCTTCATCT
GTTAAGGTAACTAAAGAAAGTACTACAATAGTAGATGGTTCTGGAGATAAAAAAGCTATAGAAGATAGAGTAACTCAAAT
TAAACATCAAGTAGAGCAAACTACTTCAGATTTTGATAGAGAGAAATTAATGGAAAGATTAGCTAAACTTGCTGGAGGAG
TAGCTGTTGTAAAAGTTGGAGCTGCTACAGAAGTAGAGTTAAAAGAAAGAAAGTTAAGAATAGAAGATGCTCTTAATGCA
ACTAGAGCAGCTGTAGAAGAAGGAATAGTAGCTGGTGGAGGAACTGCTTTTGTTAGTGTTATACCAGCAATAGGAACACT
AATTGAGAGTTTAGAAGGAGAAGTTAAACTAGGTGCTCAAATAGTTAAAAAAGCGTTAGAAGAGCCATTAAGACAAATAG
CTATAAATGCTGGTCTTGAAGGTGCTGTAATTGTGCAAAATGTTGTTAATTCTGAAGCAGAAACTGGATTTGACGCATTG
AATGAAAAATATGTAAATATGATAGAAGCTGGTATAGTTGACCCAACTAAAGTTAGTAGAAGTGCTTTACAAAATGCTGC
ATCAATAGCAAGTACTTTCTTAACTACTGAAGCTGCTGTTGCTGACCTTCCTGAAAAAGAAGATGCAGGAATGCCAGGAA
TGGGTGGCGGAATGCCTGGTATGATGTAA

Upstream 100 bases:

>100_bases
AAGTTAAGATAGAAGGACAAGAATACACAATACTAAGACAGAGTGATGTATTAGCTGTTATTGAATAAATATAGAATAAA
TTTATTAGGAGGGGTTTAAA

Downstream 100 bases:

>100_bases
TTTAAAAAATTTAAAATATAAATTTTAATATAAAGAACTATTTCGACTTAGATTTTAAACTCTAAGTTGAAATAGTTCTT
TTGTATATATCTAATTTTTG

Product: 60 kDa chaperonin

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKT
NDVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLI
AEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYILITDKKISNIQELLPVLEQIVQ
QGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASS
VKVTKESTTIVDGSGDKKAIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNA
TRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDAL
NEKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGMGGGMPGMM

Sequences:

>Translated_542_residues
MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKT
NDVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLI
AEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYILITDKKISNIQELLPVLEQIVQ
QGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASS
VKVTKESTTIVDGSGDKKAIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNA
TRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDAL
NEKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGMGGGMPGMM
>Mature_541_residues
AKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKTN
DVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLIA
EAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYILITDKKISNIQELLPVLEQIVQQ
GKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASSV
KVTKESTTIVDGSGDKKAIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNAT
RAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDALN
EKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGMGGGMPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=50.4725897920605, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=50.4725897920605, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI38455427, Length=540, Percent_Identity=23.1481481481481, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI24307939, Length=175, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=60.8286252354049, Blast_Score=620, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=49.7175141242938, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=49.7630331753554, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=32.3699421965318, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=51.8095238095238, Blast_Score=511, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322524, Length=515, Percent_Identity=24.2718446601942, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24641193, Length=530, Percent_Identity=50.377358490566, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=530, Percent_Identity=50.377358490566, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=48.1060606060606, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=48.1060606060606, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=48.1060606060606, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=43.3579335793358, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=36.1058601134215, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=36.1058601134215, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24645179, Length=513, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647245, Length=176, Percent_Identity=29.5454545454545, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_CLOD6 (Q18CT5)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086664.1
- ProteinModelPortal:   Q18CT5
- SMR:   Q18CT5
- STRING:   Q18CT5
- GeneID:   4915463
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0194
- NMPDR:   fig|1496.1.peg.1469
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   AEYENCK
- ProtClustDB:   CLSK2534418
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57772; Mature: 57641

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCEEEECCC
LEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLIAEAMEIVGKDGVITVEESQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
MNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYILITDKKISNIQELLPVLEQIVQ
CCCHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVIS
CCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EELGYDLKEADLSMLGRASSVKVTKESTTIVDGSGDKKAIEDRVTQIKHQVEQTTSDFDR
HHHCCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNATRAAVEEGIVAGGGTAFVSV
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDAL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCHHHH
NEKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGMGGGMPG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MM
CC
>Mature Secondary Structure 
AKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCEEEECCC
LEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLIAEAMEIVGKDGVITVEESQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
MNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYILITDKKISNIQELLPVLEQIVQ
CCCHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVIS
CCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EELGYDLKEADLSMLGRASSVKVTKESTTIVDGSGDKKAIEDRVTQIKHQVEQTTSDFDR
HHHCCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNATRAAVEEGIVAGGGTAFVSV
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDAL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCHHHH
NEKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGMGGGMPG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA