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The map label for this gene is 126697764

Identifier: 126697764

GI number: 126697764

Start: 249367

End: 250242

Strand: Direct

Name: 126697764

Synonym: CD0191

Alternate gene names: NA

Gene position: 249367-250242 (Clockwise)

Preceding gene: 126697763

Following gene: 126697765

Centisome position: 5.81

GC content: 29.57

Gene sequence:

>876_bases
ATGAATGTTTATGAAAAAGGTAATGGAGTTATACTAGAAGGAGTAACAGATTTTGACCCAGTACATATATTTGAGTGTGG
TCAATGTTTTAGATGGCACAAACAAGAAGATGGCTCATACACTGGAGTTGCAAAGGGGAGAATATTAAATGTCAAAAAAG
AGAATGATAAAATATATTTAAATAATACTAATTTAAAGGAGTTTAACAGCATTTGGTATAATTACTTTGATTTAGGAACT
GATTATACAGAAATAAAGAATAAGCTAAAAAATATGGATGAATATTTAAATAAGGCTACTGAATTTGGATGGGGAATAAG
AATATTAAGACAAGATGGATGGGAAATGCTTATATCATTTATAATTTCCTCTAATAATAGGATTCCTATGATACAAAGAG
CGATAGAAAATTTATCAAGAAAATTTGGTAAGTATATAGGTGAATATGAAGGTAATGAATACTATGCATTCCCAACACCA
GAAGAACTAAATAAGGCCTCACAAGAGGAAATAAGAGCATGTCAAACAGGTTTTAGAGATAAGTACATAAAAAGTACTAC
ACAGGCAGTTATAGAGAATAATGATGAGGTATCTGAATATACAAATTTAAGTACAGAGGATTGTAGAAAAGAGCTTTTAA
AATTTAATGGAGTAGGACCAAAAGTATGTGATTGTATTGCATTATTTGGTATGCAAAAATATGATTCTTTTCCAGTTGAT
GTTTGGGTTAAGAGAGTTATGCAAGAATTTTATATAGATGAAGACATGAGTTTACCTAAAATGAGAACTTATGGAATCGA
TAAATTTAAAGAAATGTCTGGATTTGCTCAACAGTACTTATTTTACTATGCAAGAGAACTCGGTATAGGAAAATAA

Upstream 100 bases:

>100_bases
TACTTATCTTTGTGTTAAAATAAGTAAAATGCACATATTAGAGCTAAGTTTTTAAGTAAATAAACAAAATGAAAATATAA
ATATTAAGGAGATTTGGTAT

Downstream 100 bases:

>100_bases
ATTAAGGGGGAGAAATTATGGGAGTAATAGGAACAATATTTCTGTTCTATTTAATTATATCATATCTAGCTGGAGCCATA
ATTTCTGTGATTATATTACT

Product: DNA glycosylase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVAKGRILNVKKENDKIYLNNTNLKEFNSIWYNYFDLGT
DYTEIKNKLKNMDEYLNKATEFGWGIRILRQDGWEMLISFIISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTP
EELNKASQEEIRACQTGFRDKYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGVGPKVCDCIALFGMQKYDSFPVD
VWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFAQQYLFYYARELGIGK

Sequences:

>Translated_291_residues
MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVAKGRILNVKKENDKIYLNNTNLKEFNSIWYNYFDLGT
DYTEIKNKLKNMDEYLNKATEFGWGIRILRQDGWEMLISFIISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTP
EELNKASQEEIRACQTGFRDKYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGVGPKVCDCIALFGMQKYDSFPVD
VWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFAQQYLFYYARELGIGK
>Mature_291_residues
MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVAKGRILNVKKENDKIYLNNTNLKEFNSIWYNYFDLGT
DYTEIKNKLKNMDEYLNKATEFGWGIRILRQDGWEMLISFIISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTP
EELNKASQEEIRACQTGFRDKYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGVGPKVCDCIALFGMQKYDSFPVD
VWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFAQQYLFYYARELGIGK

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI8670534, Length=243, Percent_Identity=27.9835390946502, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI8670542, Length=243, Percent_Identity=27.9835390946502, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4505495, Length=243, Percent_Identity=27.9835390946502, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI8670540, Length=243, Percent_Identity=27.9835390946502, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI8670530, Length=243, Percent_Identity=27.9835390946502, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI8670532, Length=243, Percent_Identity=27.9835390946502, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI8670536, Length=213, Percent_Identity=26.2910798122066, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI8670538, Length=151, Percent_Identity=25.1655629139073, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323580, Length=158, Percent_Identity=41.7721518987342, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24640654, Length=271, Percent_Identity=29.520295202952, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 34115; Mature: 34115

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVAKGRILNVKKENDKIYL
CCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCEEEEEEECCCEEEE
NNTNLKEFNSIWYNYFDLGTDYTEIKNKLKNMDEYLNKATEFGWGIRILRQDGWEMLISF
ECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTPEELNKASQEEIRACQTGFRD
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
KYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGVGPKVCDCIALFGMQKYDSFPVD
HHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
VWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFAQQYLFYYARELGIGK
HHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVAKGRILNVKKENDKIYL
CCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCEEEEEEECCCEEEE
NNTNLKEFNSIWYNYFDLGTDYTEIKNKLKNMDEYLNKATEFGWGIRILRQDGWEMLISF
ECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTPEELNKASQEEIRACQTGFRD
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
KYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGVGPKVCDCIALFGMQKYDSFPVD
HHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
VWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFAQQYLFYYARELGIGK
HHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]