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The map label for this gene is panE [H]

Identifier: 126697761

GI number: 126697761

Start: 245986

End: 246912

Strand: Direct

Name: panE [H]

Synonym: CD0188

Alternate gene names: 126697761

Gene position: 245986-246912 (Clockwise)

Preceding gene: 126697760

Following gene: 126697763

Centisome position: 5.73

GC content: 26.97

Gene sequence:

>927_bases
ATGAAAAATCAATTAAATGAAAATAATAAAAAGGTTGTATTTTTTGGAGTAGGTGCTGTAGGAGCTACTTTTGCAGAACA
ATTTTTTAACTCTAAATATGATTTTAAAATTCTTTGTGATAATGAAAGAAAGAAAAGATATTTAGAAGAAGGATTTATAA
TAAATGGAAAAAGGTATGATTTTGATTATGTAACTAAAGATGAGTATAAACAAGAGGCTGATTTTATAATTATAGGTCTA
AAATATAATAATTTAAAAGAAAATATAAAAGAATTAGATGGATTAGTTGGAAAAAATACAGTTATAATGTCTCTGCTAAA
TGGAGTTGATAGCGAAGAGATAATAGGAGAAAGATTTGGAATTGAAAAAATGGTATATTCATATGTTACCAATATAGATG
CAAAGAAAATCAATAATAATATTATACACACTACTAATGGGATAATTGTATTTGGTAACAAAGATAATAGTGAAGATAGA
AAAACTAATATAATAACCGAAGTCTTTGATGATGTAAATATAGAATATACTTTATCAAAAGATATTCAACGAGATATGTG
GTGGAAGTACATGGTTAATATTGGTGTAAATCAAACTTCAGCTATACTTGGTGCACCTTATGGAGTTTTTCAGAGTTCTG
AGCATTTAAGAGAATTAGCAAAATCTGCAATGAGGGAAGTTGTTGCTATAGCACAAGCAAAAGACATATCTCTTACAGAA
GATGATGTGGAACATTCATTACATAGAATACTAGAACATTCAAAAGAAGGAAGAACATCAATGCTTCAAGATGTGGAAGC
TCATAGACTTACAGAAGTAGATATGTTTTCTAAGAATATCTGTAAACTTGGAAAAAAATATAACATACCTACTCCTATAA
ATCAGACTTTCTTTTATATGATAAAAGTAATTGAAAGTAGATTTTAA

Upstream 100 bases:

>100_bases
TAGCTGTTTTTTTTGTTAAAAATATATTTACAAAATAAGAGATAGTAGCAGTACAATATAAGTATAAGGTAAAAGTATTA
TATATTAGGGAGGGGTAAGT

Downstream 100 bases:

>100_bases
AGGGGCTTTGTAAGAAATATTGATAATTATTGATTTTAAATTTTATTAATGTTATATACTATTTAAGTTACTAAATATTT
TTAACTCTTCAATGAAAATA

Product: ketopantoate reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKNQLNENNKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERKKRYLEEGFIINGKRYDFDYVTKDEYKQEADFIIIGL
KYNNLKENIKELDGLVGKNTVIMSLLNGVDSEEIIGERFGIEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDR
KTNIITEVFDDVNIEYTLSKDIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRELAKSAMREVVAIAQAKDISLTE
DDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMFSKNICKLGKKYNIPTPINQTFFYMIKVIESRF

Sequences:

>Translated_308_residues
MKNQLNENNKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERKKRYLEEGFIINGKRYDFDYVTKDEYKQEADFIIIGL
KYNNLKENIKELDGLVGKNTVIMSLLNGVDSEEIIGERFGIEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDR
KTNIITEVFDDVNIEYTLSKDIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRELAKSAMREVVAIAQAKDISLTE
DDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMFSKNICKLGKKYNIPTPINQTFFYMIKVIESRF
>Mature_308_residues
MKNQLNENNKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERKKRYLEEGFIINGKRYDFDYVTKDEYKQEADFIIIGL
KYNNLKENIKELDGLVGKNTVIMSLLNGVDSEEIIGERFGIEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDR
KTNIITEVFDDVNIEYTLSKDIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRELAKSAMREVVAIAQAKDISLTE
DDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMFSKNICKLGKKYNIPTPINQTFFYMIKVIESRF

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=300, Percent_Identity=22.3333333333333, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 35585; Mature: 35585

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQLNENNKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERKKRYLEEGFIINGKRYD
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCEECCCCCC
FDYVTKDEYKQEADFIIIGLKYNNLKENIKELDGLVGKNTVIMSLLNGVDSEEIIGERFG
CCCCCHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
IEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDRKTNIITEVFDDVNIEYTLSK
HHHHHHHHHHCCCHHHHCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECH
DIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRELAKSAMREVVAIAQAKDISLTE
HHHHHHHHHHHHHCCCCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMFSKNICKLGKKYNIPTPINQTFFYM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IKVIESRF
HHHHHHCC
>Mature Secondary Structure
MKNQLNENNKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERKKRYLEEGFIINGKRYD
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCEECCCCCC
FDYVTKDEYKQEADFIIIGLKYNNLKENIKELDGLVGKNTVIMSLLNGVDSEEIIGERFG
CCCCCHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
IEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDRKTNIITEVFDDVNIEYTLSK
HHHHHHHHHHCCCHHHHCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECH
DIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRELAKSAMREVVAIAQAKDISLTE
HHHHHHHHHHHHHCCCCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMFSKNICKLGKKYNIPTPINQTFFYM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IKVIESRF
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]