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The map label for this gene is pyrE

Identifier: 126697760

GI number: 126697760

Start: 245187

End: 245771

Strand: Direct

Name: pyrE

Synonym: CD0187

Alternate gene names: 126697760

Gene position: 245187-245771 (Clockwise)

Preceding gene: 126697759

Following gene: 126697761

Centisome position: 5.71

GC content: 33.33

Gene sequence:

>585_bases
ATGAGTAAAGTAGATGTAGTGGATATATTAAAGAAAAGTGATGCATTGTTGGAGGGACATTTTTTATTATCTTCAGGAAA
ACACAGTAATAGATACGTACAATGTGCAAAAGTATTAAGATTCCCAGAATATGCTGCTGAGGTATTAAGTACAGTTGTTG
AACAAATAAAAGACTTAGATATAGACTTAGTAGTAGGACCAGCTATGGGTGGAGTAATAGTTTCTTATGAGTTAGGAAGA
CAATTAGGAAAAGAAGCTGTATTTACTGAGAGAAAAGACAATACAATGGAGTTAAGAAGAGGATTTGAAGTTAAAAAAGG
AGCAAAGATAATAATTGCTGAAGACGTTGTAACTACTGGTAAATCAACTATGGAGACAAAAAGAGTATTAGAAGCCTTAG
GTGGAGAAGTTGTAGGTGTTGCATGTATAGCAGATAGAACTAATCATGATATAGGTATGCCTATATATAGTGCTATAAAA
CTTGATATTCAAGTTTATGAATCTGATGAGTGTCCTTTATGTAAGGAAGGAAAATTACCAGTTGTTAAGCCTGGAAGTAG
AGAGTTCAAGGAATTAGGGATGTAA

Upstream 100 bases:

>100_bases
AAGAGGAATTATATAAGGTAGAATAAATAGTATTTTAAAGATAAAAAATATAGATTAAATAAACAATAATTTTATAACAT
TAACATGGAGGAAAAATAAT

Downstream 100 bases:

>100_bases
TAAAAACTTAATTATTTATAGTGTTACTTAAAAAATGTAAATTTTTTAGAGTAAAAATTTGTAATATAACATATAACTTA
AAAATAAAAAGCAGTTAGCC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEYAAEVLSTVVEQIKDLDIDLVVGPAMGGVIVSYELGR
QLGKEAVFTERKDNTMELRRGFEVKKGAKIIIAEDVVTTGKSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIK
LDIQVYESDECPLCKEGKLPVVKPGSREFKELGM

Sequences:

>Translated_194_residues
MSKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEYAAEVLSTVVEQIKDLDIDLVVGPAMGGVIVSYELGR
QLGKEAVFTERKDNTMELRRGFEVKKGAKIIIAEDVVTTGKSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIK
LDIQVYESDECPLCKEGKLPVVKPGSREFKELGM
>Mature_193_residues
SKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEYAAEVLSTVVEQIKDLDIDLVVGPAMGGVIVSYELGRQ
LGKEAVFTERKDNTMELRRGFEVKKGAKIIIAEDVVTTGKSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIKL
DIQVYESDECPLCKEGKLPVVKPGSREFKELGM

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CLOD6 (Q18CS5)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086657.1
- ProteinModelPortal:   Q18CS5
- STRING:   Q18CS5
- GeneID:   4915023
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0187
- NMPDR:   fig|1496.1.peg.1476
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 21301; Mature: 21170

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 118-118 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEYAAEVLSTVVEQIKDLD
CCCCHHHHHHHHCCCCEECEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
IDLVVGPAMGGVIVSYELGRQLGKEAVFTERKDNTMELRRGFEVKKGAKIIIAEDVVTTG
EEEEECCCCCCEEEEEHHHHHHCHHHHHCCCCCCHHHHHCCCCCCCCCEEEEECCHHHCC
KSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIKLDIQVYESDECPLCKEGKLP
CHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCC
VVKPGSREFKELGM
EECCCCHHHHHCCC
>Mature Secondary Structure 
SKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEYAAEVLSTVVEQIKDLD
CCCHHHHHHHHCCCCEECEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
IDLVVGPAMGGVIVSYELGRQLGKEAVFTERKDNTMELRRGFEVKKGAKIIIAEDVVTTG
EEEEECCCCCCEEEEEHHHHHHCHHHHHCCCCCCHHHHHCCCCCCCCCEEEEECCHHHCC
KSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIKLDIQVYESDECPLCKEGKLP
CHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCC
VVKPGSREFKELGM
EECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA