Click here to switch to the map view.

The map label for this gene is gcp

Identifier: 126697724

GI number: 126697724

Start: 200727

End: 201743

Strand: Direct

Name: gcp

Synonym: CD0152

Alternate gene names: 126697724

Gene position: 200727-201743 (Clockwise)

Preceding gene: 126697723

Following gene: 126697725

Centisome position: 4.68

GC content: 32.94

Gene sequence:

>1017_bases
ATGAGTGATATAATAACATTAGCTATAGAGAGTAGTTGTGACGAAACAGCTGCATCAGTTTTAAAAAATGGTAGAGAAGT
ACTTTCAAACATAATCTCTACTCAAATCGAGACACATAAAAAATTTGGTGGTGTAGTTCCAGAAGTGGCCTCAAGAAAAC
ATGTGGAAAATATTGATATAGTTGTTCAAGAAGCTTTAGACAAAGCAAATATAGGTTTTAATGATATAGACCATATCGCA
GTTACATATGGACCTGGGCTAGTAGGTGCTTTATTGGTTGGTCTATCTTATGCTAAAGCACTTGCATATACTTTGAATAT
TCCACTTGTAGGAGTAAATCATATAGAAGGGCATCTAAGTGCAAACTATATAGAGCATAAGGATTTAAAACCTCCTTTTA
TAACATTAATAGTATCTGGAGGTCATACTCACTTGGTTGAAGTAAAAGATTATGGCAAGTATGAAATTTTAGGAAAAACA
AGAGATGATGCATCTGGAGAAGCATTTGATAAGATTTCAAGAGCTATGAATTTAGGCTATCCAGGAGGTCCTATTATTGA
TAATCTGGCCAAAAATGGAAATAAACATGCTATAGAATTTCCAAGAGCCTATTTAGAAGAAGATAGCTATGATTTTAGTT
TTAGTGGATTAAAATCTTCTGTATTAAATTATCTAAATGGAAAAAGAATGAAAAATGAAGAAATAGTAGTTGAAGATGTA
GCAGCATCTTTCCAAGAGGCTGTAGTAGAGGTTTTATCTACTAAAGCACTAAAAGCAGTAAAAGACAAAGGATACAATAT
CATAACTCTTTCTGGTGGGGTTGCTTCTAATTCGGGGCTTAGAGCTAAAATAACAGAGCTTGCTAAAGACAATGGTATTA
CTGTTAAGTATCCTCCTCTAATTTTATGCACAGATAATGCAGCTATGATAGGGTGTGCAGGATATTATAATTTTATAAAT
GGGAAAACGCATGATATGAGTTTAAATGCAGTTCCAAATTTAAAGATAAATCAGTAG

Upstream 100 bases:

>100_bases
AATATGGATTTAAAATGGGTGGAATAAGAAAAGAATACTACAGTGATAATAAAGAAGATGCAATTATAATGTGGAACCAA
TTAAAAGAGGTGTAGAGTTT

Downstream 100 bases:

>100_bases
AGTTAGATGAATTTGTAAATATAAAAGTATTGTTTCAAAAAAGTAAGTAGAAGTGAAATTAAATATAATAAAAATAAATA
TAGTATATATTAAAACTTGA

Product: DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGGVVPEVASRKHVENIDIVVQEALDKANIGFNDIDHIA
VTYGPGLVGALLVGLSYAKALAYTLNIPLVGVNHIEGHLSANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKT
RDDASGEAFDKISRAMNLGYPGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLKSSVLNYLNGKRMKNEEIVVEDV
AASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVASNSGLRAKITELAKDNGITVKYPPLILCTDNAAMIGCAGYYNFIN
GKTHDMSLNAVPNLKINQ

Sequences:

>Translated_338_residues
MSDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGGVVPEVASRKHVENIDIVVQEALDKANIGFNDIDHIA
VTYGPGLVGALLVGLSYAKALAYTLNIPLVGVNHIEGHLSANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKT
RDDASGEAFDKISRAMNLGYPGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLKSSVLNYLNGKRMKNEEIVVEDV
AASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVASNSGLRAKITELAKDNGITVKYPPLILCTDNAAMIGCAGYYNFIN
GKTHDMSLNAVPNLKINQ
>Mature_337_residues
SDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGGVVPEVASRKHVENIDIVVQEALDKANIGFNDIDHIAV
TYGPGLVGALLVGLSYAKALAYTLNIPLVGVNHIEGHLSANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKTR
DDASGEAFDKISRAMNLGYPGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLKSSVLNYLNGKRMKNEEIVVEDVA
ASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVASNSGLRAKITELAKDNGITVKYPPLILCTDNAAMIGCAGYYNFING
KTHDMSLNAVPNLKINQ

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=33.7278106508876, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI8923380, Length=328, Percent_Identity=30.7926829268293, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=40.7185628742515, Blast_Score=274, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17557464, Length=327, Percent_Identity=30.2752293577982, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71995670, Length=330, Percent_Identity=30, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320099, Length=338, Percent_Identity=35.207100591716, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322891, Length=328, Percent_Identity=28.6585365853659, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20129063, Length=342, Percent_Identity=31.2865497076023, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI21357207, Length=330, Percent_Identity=30.3030303030303, Blast_Score=124, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_CLOD6 (Q18CP0)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086621.1
- ProteinModelPortal:   Q18CP0
- SMR:   Q18CP0
- STRING:   Q18CP0
- MEROPS:   M22.001
- GeneID:   4914358
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0152
- NMPDR:   fig|1496.1.peg.1514
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36493; Mature: 36362

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGGVVPEVASRKHVENIDI
CCCEEEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHH
VVQEALDKANIGFNDIDHIAVTYGPGLVGALLVGLSYAKALAYTLNIPLVGVNHIEGHLS
HHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCC
ANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKTRDDASGEAFDKISRAMNLGY
CCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
PGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLKSSVLNYLNGKRMKNEEIVVEDV
CCCHHHHHHHCCCCCCEEECCHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHH
AASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVASNSGLRAKITELAKDNGITVKYPPL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEECCE
ILCTDNAAMIGCAGYYNFINGKTHDMSLNAVPNLKINQ
EEECCCCEEEEEHHHHHHCCCCCCCEEECCCCCCEECC
>Mature Secondary Structure 
SDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGGVVPEVASRKHVENIDI
CCEEEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHH
VVQEALDKANIGFNDIDHIAVTYGPGLVGALLVGLSYAKALAYTLNIPLVGVNHIEGHLS
HHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCC
ANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKTRDDASGEAFDKISRAMNLGY
CCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
PGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLKSSVLNYLNGKRMKNEEIVVEDV
CCCHHHHHHHCCCCCCEEECCHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHH
AASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVASNSGLRAKITELAKDNGITVKYPPL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEECCE
ILCTDNAAMIGCAGYYNFINGKTHDMSLNAVPNLKINQ
EEECCCCEEEEEHHHHHHCCCCCCCEEECCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA