Click here to switch to the map view.

The map label for this gene is thyX [H]

Identifier: 126697620

GI number: 126697620

Start: 80900

End: 81658

Strand: Direct

Name: thyX [H]

Synonym: CD0054

Alternate gene names: 126697620

Gene position: 80900-81658 (Clockwise)

Preceding gene: 126697619

Following gene: 126697621

Centisome position: 1.89

GC content: 30.3

Gene sequence:

>759_bases
ATGAAAGTAAAATTAATATCACATACACCTGAACCAGAAAAAGTAATAGCTATGGCAGCTAAGCTATGTTATTCACCAGT
TGGGACAGACGAAATAGAAAAAGACTTAACAGATGAAAGTATAGAGAAATTTTTAAATATGTTATTAAGTATAGGTCATG
GGTCAATATTAGAACATGCTTCATTTACATTTTCAATAGAAGGTATTTCAAGGGCTTGTTCACATCAAATTGTTAGACAT
CGTATAGCTAGTTTTTCACAACAAAGTCAAAGATATGTTAAATTAGAACAATTTGAGTACATAATTCCTCCAGAAATAGA
AAAAATAGAAAAGGCAAAAGAGTTATTTATAGACTCCATGAAAAAAGACCAAGAGAATTATGATAAGTTAGTTGAAATAT
TGTTTGAAAATCATTATAATGACCTAATAAAAAACGGTAAAAATGAGAAAACAGCTAAAAGACAAGCTGAAAAGAAAGCA
ATAGAAGATGCTAGATACGTATTTCCAAATGCATGTGAAACAAAAATGGTATTTACTATAAATGCTAGAAGTTTGTTTAA
TTTCTTTGAACATAGATGCTGTGAAAGAGCACAGTGGGAAATAAGAAATTTAGCTGTGGAGATGTTAAGAGAGGTTAAAA
AGGTTGCTCCTATATTATTTAAAAAGACTGGTCCAAGTTGTGTAAATGGAAGTTGTCCAGAAGGAACTATGACTTGTGGA
GATATAGTTCAAGTTAGAGAAAAATTTAAGGCCTTGTAG

Upstream 100 bases:

>100_bases
AAAGAGTGTTGTCTTAATAATAAGTAATAAGGCAACACTTTTTTTATAACTAATGTATAATAAATATATAGAAATTAGTA
ATGAGAAAGGATAAAAAGTT

Downstream 100 bases:

>100_bases
GAGGTGAATAATTTGGCGAGTATAGAAGGAAGAAATCCGGTAATAGAAGCAATAAAAAGCGACAGAGAAATAGATAAAAT
ATTAATTGCAAATTCAGCTA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKFLNMLLSIGHGSILEHASFTFSIEGISRACSHQIVRH
RIASFSQQSQRYVKLEQFEYIIPPEIEKIEKAKELFIDSMKKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKA
IEDARYVFPNACETKMVFTINARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPILFKKTGPSCVNGSCPEGTMTCG
DIVQVREKFKAL

Sequences:

>Translated_252_residues
MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKFLNMLLSIGHGSILEHASFTFSIEGISRACSHQIVRH
RIASFSQQSQRYVKLEQFEYIIPPEIEKIEKAKELFIDSMKKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKA
IEDARYVFPNACETKMVFTINARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPILFKKTGPSCVNGSCPEGTMTCG
DIVQVREKFKAL
>Mature_252_residues
MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKFLNMLLSIGHGSILEHASFTFSIEGISRACSHQIVRH
RIASFSQQSQRYVKLEQFEYIIPPEIEKIEKAKELFIDSMKKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKA
IEDARYVFPNACETKMVFTINARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPILFKKTGPSCVNGSCPEGTMTCG
DIVQVREKFKAL

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 29015; Mature: 29015

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKFLNMLLSIGHGSILEHA
CEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHC
SFTFSIEGISRACSHQIVRHRIASFSQQSQRYVKLEQFEYIIPPEIEKIEKAKELFIDSM
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKAIEDARYVFPNACETKMVFTI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPILFKKTGPSCVNGSCPEGTMTCG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
DIVQVREKFKAL
HHHHHHHHHHCC
>Mature Secondary Structure
MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKFLNMLLSIGHGSILEHA
CEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHC
SFTFSIEGISRACSHQIVRHRIASFSQQSQRYVKLEQFEYIIPPEIEKIEKAKELFIDSM
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKAIEDARYVFPNACETKMVFTI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPILFKKTGPSCVNGSCPEGTMTCG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
DIVQVREKFKAL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]