Click here to switch to the map view.

The map label for this gene is acoB [H]

Identifier: 126697603

GI number: 126697603

Start: 59447

End: 60433

Strand: Direct

Name: acoB [H]

Synonym: CD0037

Alternate gene names: 126697603

Gene position: 59447-60433 (Clockwise)

Preceding gene: 126697602

Following gene: 126697604

Centisome position: 1.39

GC content: 35.06

Gene sequence:

>987_bases
ATGAGTACAAGGGAATTAACATATGCACAAGCAATAAAGGAAGCAATGTCAGAAGAAATGAGAAGAGATGAAAATGTAAT
ATTTATGGGAGAAGATATAGGAATATATGGAGGAGCATTTGGTGTATCAGTTGGTATGATAGATGAATTTGGACCAGAAA
GAGTAAGGGATACTCCTATATCAGAAGCAGCTATAGCAGGAGCGGCAGCAGGTGCAGCAGCAACTGGCTTAAGACCTATT
ATGGAAGTAATGTTTATGGACTTTGTAACAATTTCTATGGATGCAATTGTAAATCAAGCGGCAAAAATGAGATATATGTT
TGGAGGAAAAGCACAAGTTCCAATGGTTGTTAGATGTCCAGGAGGTTCTGGAACTGGTTCAGCAGAGCAACATTCACAAA
GTTTAGAAGCTTGGTTTTGTCATGTACCAGGAGTAAAAGTAGTTGCACCTTCTACACCAGCAGATGCTAAGGGATTGTTG
AAAGCAGCTATAAGAGATAATAATCCAGTCATATTTGTTGAGAATAAATTGTTATACAGAAAAAAAGGTTTTGTGCCAGA
AGATGATTATGTAATTGAAATTGGAAAGGCAGATATTAAAAGAGAGGGTACTGATGTTACAGTAATTACTTATGGAAGAA
TGTTACAAAGTGTTGAAGAAGCAGCAGAGACTCTATCAAAAGAAAATATAAATGTTGAAATTATAGATTTAAGAACTTTA
TATCCATTAGATAAAGAGACTATAGTAAAGAGTGTATGTAAAACTGGGAGAGTTTTAATTTGCCATGAAGCAGCTAAGAC
TGGTGGGCTAGGTGGAGAAATATCAGCCCTGATAACAGAAAGTGAATCATTTGATTATTTAGATGCTCCAGTAAAAAGAA
TTTGTGGAAAAGATGTGCCAATACCATATAATCCAGAGTTAGAAAAAGCAGTTGTCCCAAGAGTTGATGAAATAGAAGAA
GCAATAAAATCTTTAATTGTTAGATAA

Upstream 100 bases:

>100_bases
AGATGCAGTAGAGTTTGCTCAAAATAGCCCAAATCCAAAAATAGAGTCTTTATTAGAGGATGTATATGCAGACTAAGAAT
GGTAAAGGAGGAAAATAAAA

Downstream 100 bases:

>100_bases
GGAGGGATAGATATGGTGGCAAATAAAATAAAAGCCACACCAGCAGCTAGAAGTCAGGCAAGAAAAGACAATATAAAATT
AGATAGGCTGATTGGAAGTG

Product: acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSTRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSVGMIDEFGPERVRDTPISEAAIAGAAAGAAATGLRPI
MEVMFMDFVTISMDAIVNQAAKMRYMFGGKAQVPMVVRCPGGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLL
KAAIRDNNPVIFVENKLLYRKKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSVEEAAETLSKENINVEIIDLRTL
YPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISALITESESFDYLDAPVKRICGKDVPIPYNPELEKAVVPRVDEIEE
AIKSLIVR

Sequences:

>Translated_328_residues
MSTRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSVGMIDEFGPERVRDTPISEAAIAGAAAGAAATGLRPI
MEVMFMDFVTISMDAIVNQAAKMRYMFGGKAQVPMVVRCPGGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLL
KAAIRDNNPVIFVENKLLYRKKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSVEEAAETLSKENINVEIIDLRTL
YPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISALITESESFDYLDAPVKRICGKDVPIPYNPELEKAVVPRVDEIEE
AIKSLIVR
>Mature_327_residues
STRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSVGMIDEFGPERVRDTPISEAAIAGAAAGAAATGLRPIM
EVMFMDFVTISMDAIVNQAAKMRYMFGGKAQVPMVVRCPGGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLLK
AAIRDNNPVIFVENKLLYRKKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSVEEAAETLSKENINVEIIDLRTLY
PLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISALITESESFDYLDAPVKRICGKDVPIPYNPELEKAVVPRVDEIEEA
IKSLIVR

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=46.319018404908, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=43.8650306748466, Blast_Score=268, Evalue=4e-72,
Organism=Homo sapiens, GI4557353, Length=329, Percent_Identity=40.7294832826748, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI34101272, Length=329, Percent_Identity=40.7294832826748, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17538422, Length=329, Percent_Identity=45.5927051671732, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17506935, Length=323, Percent_Identity=40.2476780185758, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319698, Length=329, Percent_Identity=45.2887537993921, Blast_Score=300, Evalue=3e-82,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=42.3312883435583, Blast_Score=277, Evalue=8e-75,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=42.3312883435583, Blast_Score=277, Evalue=8e-75,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=42.3312883435583, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI160714832, Length=326, Percent_Identity=42.3312883435583, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24650943, Length=96, Percent_Identity=41.6666666666667, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650945, Length=96, Percent_Identity=41.6666666666667, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35625; Mature: 35494

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSVGMIDEFGPERVRDTPI
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCHHHCEECCHHHCCCHHHCCCCC
SEAAIAGAAAGAAATGLRPIMEVMFMDFVTISMDAIVNQAAKMRYMFGGKAQVPMVVRCP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEECC
GGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLLKAAIRDNNPVIFVENKLLYR
CCCCCCCHHHHHHHHHHEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEH
KKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSVEEAAETLSKENINVEIIDLRTL
HCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEE
YPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISALITESESFDYLDAPVKRICGKDVP
CCCCHHHHHHHHHHCCCEEEEECCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
IPYNPELEKAVVPRVDEIEEAIKSLIVR
CCCCCCHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSVGMIDEFGPERVRDTPI
CCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCHHHCEECCHHHCCCHHHCCCCC
SEAAIAGAAAGAAATGLRPIMEVMFMDFVTISMDAIVNQAAKMRYMFGGKAQVPMVVRCP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEECC
GGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLLKAAIRDNNPVIFVENKLLYR
CCCCCCCHHHHHHHHHHEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEH
KKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSVEEAAETLSKENINVEIIDLRTL
HCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEE
YPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISALITESESFDYLDAPVKRICGKDVP
CCCCHHHHHHHHHHCCCEEEEECCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
IPYNPELEKAVVPRVDEIEEAIKSLIVR
CCCCCCHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]