Click here to switch to the map view.

The map label for this gene is adh [H]

Identifier: 126447560

GI number: 126447560

Start: 1651346

End: 1652386

Strand: Reverse

Name: adh [H]

Synonym: BMA10247_A1718

Alternate gene names: 126447560

Gene position: 1652386-1651346 (Counterclockwise)

Preceding gene: 126446046

Following gene: 126445919

Centisome position: 70.23

GC content: 68.97

Gene sequence:

>1041_bases
ATGAAAGCGCTGGTGTATCACGGGCCGGGCCGCAAGTCGCTGGACGAGCGCCCGATGCCCGAGCTGGCCGCGCCGACGGA
CGTCATCGTGCGCGTCACGCGCACGACGATCTGCGGCACCGATCTGCACATCCTGAAGGGCGACGTGCCGAGCTGCGAGC
CGGGGCGCGTGCTCGGCCATGAGGGCGTGGGCGTTGTGCATCGCGCGGGCGGCGCGGTGAGCACGTTCAAGGAGGGCGAC
CGCGTGCTGATCTCGTGCATTTCGTCGTGCGGGCAGTGCGAATACTGCCGGCGCGGGATGTATTCGCACTGCGCGACGGG
CGGCTGGATTCTCGGCAACCGGATCGACGGCACGCAGGCCGAATACGTGCGGATTCCGCACGCGCAGACGAGCCTGTACC
GGATCGCGCCGGGCGCCGACGAGGAGGCGCTCGTGATGCTGTCCGACATCCTGCCGACGGGCTTCGAGTGCGGCGTGCTG
AACGGCCGCGTGCAGCCGGGGGGCACGGTCGCGATCATCGGCGCGGGGCCGATCGGGCTCGCGGCGCTGTTGACCGCGCA
GTTCTATTCGCCCGCGCAGATCGTGATGATCGATCCGGACCCGAACCGGCTCGCGCTCGCGCGGCGCTTCGGCGCGACCG
CGTGCATCGACAACGGCCAGGTCGACGCGGTGGCCGGCGTGAAGGCGTTGACGGGCGACGGCGTGGATTGCGCGATCGAG
GCAGTCGGCATTCCGGCGTCGTTCGAGCTGTGCCAGCGGATCATCGCGCCGGGCGGCGTGATCGCCAACGTCGGCGTGCA
CGGCATGAAGGCGGATCTGCATCTCGAGACGCTGTGGGACCGTAACATCACGATCACGACCCGGCTCGTCGACACGTCGA
GCACGCCGATGCTGCTGAAGACCGTCGGCGCGGGACGGCTCGACCCGAAGCAACTGATCACGCACCGTTTTTCGCTCGCG
GATATCGGGCAGGCGTACGAGACGTTCGGTCATGCGGCGCACACGCGCGCGCTGAAGGTCATCGTCGAGGTGTCCGAGTA
G

Upstream 100 bases:

>100_bases
CGCGCGCCGCGCCGTTTGACGCGCGTCAACGGGCGGGCGTGCGACGCGCCTAGAGTGAGGCGTGAGGGGCATTGCGCGCC
CCGCGAGCGGAGGACACGAC

Downstream 100 bases:

>100_bases
GCGGGCGCGCGGCGGCAGGCACGGCGCGAGGGCTTGTCGCTTTTTGCCGTTTGCGGCGCTCGCGCCTCGCTGCCTGCTGC
TTGTTGCGCGTTGCTCGCGA

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKALVYHGPGRKSLDERPMPELAAPTDVIVRVTRTTICGTDLHILKGDVPSCEPGRVLGHEGVGVVHRAGGAVSTFKEGD
RVLISCISSCGQCEYCRRGMYSHCATGGWILGNRIDGTQAEYVRIPHAQTSLYRIAPGADEEALVMLSDILPTGFECGVL
NGRVQPGGTVAIIGAGPIGLAALLTAQFYSPAQIVMIDPDPNRLALARRFGATACIDNGQVDAVAGVKALTGDGVDCAIE
AVGIPASFELCQRIIAPGGVIANVGVHGMKADLHLETLWDRNITITTRLVDTSSTPMLLKTVGAGRLDPKQLITHRFSLA
DIGQAYETFGHAAHTRALKVIVEVSE

Sequences:

>Translated_346_residues
MKALVYHGPGRKSLDERPMPELAAPTDVIVRVTRTTICGTDLHILKGDVPSCEPGRVLGHEGVGVVHRAGGAVSTFKEGD
RVLISCISSCGQCEYCRRGMYSHCATGGWILGNRIDGTQAEYVRIPHAQTSLYRIAPGADEEALVMLSDILPTGFECGVL
NGRVQPGGTVAIIGAGPIGLAALLTAQFYSPAQIVMIDPDPNRLALARRFGATACIDNGQVDAVAGVKALTGDGVDCAIE
AVGIPASFELCQRIIAPGGVIANVGVHGMKADLHLETLWDRNITITTRLVDTSSTPMLLKTVGAGRLDPKQLITHRFSLA
DIGQAYETFGHAAHTRALKVIVEVSE
>Mature_346_residues
MKALVYHGPGRKSLDERPMPELAAPTDVIVRVTRTTICGTDLHILKGDVPSCEPGRVLGHEGVGVVHRAGGAVSTFKEGD
RVLISCISSCGQCEYCRRGMYSHCATGGWILGNRIDGTQAEYVRIPHAQTSLYRIAPGADEEALVMLSDILPTGFECGVL
NGRVQPGGTVAIIGAGPIGLAALLTAQFYSPAQIVMIDPDPNRLALARRFGATACIDNGQVDAVAGVKALTGDGVDCAIE
AVGIPASFELCQRIIAPGGVIANVGVHGMKADLHLETLWDRNITITTRLVDTSSTPMLLKTVGAGRLDPKQLITHRFSLA
DIGQAYETFGHAAHTRALKVIVEVSE

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=27.8443113772455, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI71565154, Length=351, Percent_Identity=25.3561253561254, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4501929, Length=351, Percent_Identity=25.3561253561254, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI34577061, Length=353, Percent_Identity=26.0623229461756, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=26.0623229461756, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=26.0623229461756, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=26.1838440111421, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=26.1838440111421, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4501933, Length=353, Percent_Identity=23.7960339943343, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=375, Percent_Identity=29.6, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1788073, Length=325, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=26.2247838616715, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI87082125, Length=349, Percent_Identity=29.2263610315186, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788075, Length=360, Percent_Identity=28.0555555555556, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786552, Length=345, Percent_Identity=30.7246376811594, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790045, Length=324, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=28.3489096573209, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI226510992, Length=332, Percent_Identity=26.5060240963855, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788407, Length=339, Percent_Identity=28.023598820059, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=292, Percent_Identity=29.1095890410959, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=27.4924471299094, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=345, Percent_Identity=27.8260869565217, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=346, Percent_Identity=27.1676300578035, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71997431, Length=352, Percent_Identity=27.5568181818182, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=27.893175074184, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=359, Percent_Identity=27.5766016713092, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=340, Percent_Identity=27.3529411764706, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=27.3529411764706, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=341, Percent_Identity=26.9794721407625, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=304, Percent_Identity=26.9736842105263, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=359, Percent_Identity=24.2339832869081, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=271, Percent_Identity=28.0442804428044, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=269, Percent_Identity=28.996282527881, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=275, Percent_Identity=29.0909090909091, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=269, Percent_Identity=28.996282527881, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=29.2168674698795, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=30.7228915662651, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17737895, Length=352, Percent_Identity=26.1363636363636, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221457811, Length=324, Percent_Identity=23.1481481481481, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45550770, Length=324, Percent_Identity=23.1481481481481, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45551930, Length=324, Percent_Identity=23.1481481481481, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36566; Mature: 36566

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVYHGPGRKSLDERPMPELAAPTDVIVRVTRTTICGTDLHILKGDVPSCEPGRVLGH
CCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEHEECCCCEEEEECCCCCCCCCCEECC
EGVGVVHRAGGAVSTFKEGDRVLISCISSCGQCEYCRRGMYSHCATGGWILGNRIDGTQA
CCCEEEEECCCCCHHHHCCCHHHHHHHHCCCCCHHHHCCHHHHHCCCCEEECCCCCCCCC
EYVRIPHAQTSLYRIAPGADEEALVMLSDILPTGFECGVLNGRVQPGGTVAIIGAGPIGL
EEEECCCCCCCEEEECCCCCCCHHHEEEHHCCCCCEEEEECCEECCCCEEEEEECCHHHH
AALLTAQFYSPAQIVMIDPDPNRLALARRFGATACIDNGQVDAVAGVKALTGDGVDCAIE
HHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCEEHHHCEEEECCCCCEEEEE
AVGIPASFELCQRIIAPGGVIANVGVHGMKADLHLETLWDRNITITTRLVDTSSTPMLLK
EECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEECCCCEEEEEEEEECCCCCEEEE
TVGAGRLDPKQLITHRFSLADIGQAYETFGHAAHTRALKVIVEVSE
ECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEEEECC
>Mature Secondary Structure
MKALVYHGPGRKSLDERPMPELAAPTDVIVRVTRTTICGTDLHILKGDVPSCEPGRVLGH
CCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEHEECCCCEEEEECCCCCCCCCCEECC
EGVGVVHRAGGAVSTFKEGDRVLISCISSCGQCEYCRRGMYSHCATGGWILGNRIDGTQA
CCCEEEEECCCCCHHHHCCCHHHHHHHHCCCCCHHHHCCHHHHHCCCCEEECCCCCCCCC
EYVRIPHAQTSLYRIAPGADEEALVMLSDILPTGFECGVLNGRVQPGGTVAIIGAGPIGL
EEEECCCCCCCEEEECCCCCCCHHHEEEHHCCCCCEEEEECCEECCCCEEEEEECCHHHH
AALLTAQFYSPAQIVMIDPDPNRLALARRFGATACIDNGQVDAVAGVKALTGDGVDCAIE
HHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCEEHHHCEEEECCCCCEEEEE
AVGIPASFELCQRIIAPGGVIANVGVHGMKADLHLETLWDRNITITTRLVDTSSTPMLLK
EECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEECCCCEEEEEEEEECCCCCEEEE
TVGAGRLDPKQLITHRFSLADIGQAYETFGHAAHTRALKVIVEVSE
ECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]