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The map label for this gene is fnr [H]

Identifier: 126447426

GI number: 126447426

Start: 31336

End: 32091

Strand: Reverse

Name: fnr [H]

Synonym: BMA10247_A0037

Alternate gene names: 126447426

Gene position: 32091-31336 (Counterclockwise)

Preceding gene: 126446632

Following gene: 126447570

Centisome position: 1.36

GC content: 67.2

Gene sequence:

>756_bases
ATGCTTACGCCCGTCGCCCGACCTGCCGCCGCCGCGGCTCCCGTCCATGCCTCCAGCACGTGGGCGCCGCGTCAGGCCGC
GCACTGCTCGACGTGCGCGATGCGTCATCTCTGCATGCCCCAGGGGCTCGCGCCGGAAGCGCTCGCGCGCCTCGAATCCG
TGATCTGCACCGCCCGCCCGGTCCGCCGCGGCGAAACGCTGTTCCGCGAGGGCGATACGTTCGACAACCTGTACGCGGTG
CGCTCGGGATCGCTGAAGACCATCGCGACGCGCCACGACGGCCGCGAGCAGGTCACCGGCCTGCATCTCGCGGGCGAGGC
GCTCGGCCTCGACGGCATCTGCGACGACGCGCATCCGCGCACCGCGGTCGCGCTCGAAGACAGCTCGGTCTGCGTGATTC
CGTACAGCGCGTTGAAAACGCTGTGCTCGGAGGCGGGCACGATTCAATTGCGGATGCACAAGCTGATGAGCGAGCAGATC
GTCCGCGAGACGTCGCAGACGATGGTGCTCGGCTCGCTGAACGCCGAAGAACGCGTCGCGGCGTTCCTGCTCGACGTGTC
GTCGCGTTACATGAAGCGCGGCTATTCGCCGAACGAATTCAACCTGCGAATGACGCGCGAGGACATCGGCAGCTATCTCG
GCATGACGCTCGAGACGGTCAGCCGCACGCTGTCGAAATTCCACAAGCGCGGCCTGATCGAGATGCAGGGCCGGATGGTC
CGCATCGTCGATTTCGACGGGCTGCACCGGCTGTAA

Upstream 100 bases:

>100_bases
ACAAGGAAATCGCACGGGGAGTCGCGGCGTTTTGTCGCTAAACAGGCTTAGTCCACGATGGGACAATGGCTTTACCGATT
CAACCTCAGAGCCATCCATC

Downstream 100 bases:

>100_bases
CCGGGCGCGCGGCGCCCGCCCCTTTCGCCTCGCCCCCCTCAACCGGTCAGTCGAGATACTGCGCGGCGCTCGCCTTGAGC
GCCGCGCTGAACTCGTCCAG

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLTPVARPAAAAAPVHASSTWAPRQAAHCSTCAMRHLCMPQGLAPEALARLESVICTARPVRRGETLFREGDTFDNLYAV
RSGSLKTIATRHDGREQVTGLHLAGEALGLDGICDDAHPRTAVALEDSSVCVIPYSALKTLCSEAGTIQLRMHKLMSEQI
VRETSQTMVLGSLNAEERVAAFLLDVSSRYMKRGYSPNEFNLRMTREDIGSYLGMTLETVSRTLSKFHKRGLIEMQGRMV
RIVDFDGLHRL

Sequences:

>Translated_251_residues
MLTPVARPAAAAAPVHASSTWAPRQAAHCSTCAMRHLCMPQGLAPEALARLESVICTARPVRRGETLFREGDTFDNLYAV
RSGSLKTIATRHDGREQVTGLHLAGEALGLDGICDDAHPRTAVALEDSSVCVIPYSALKTLCSEAGTIQLRMHKLMSEQI
VRETSQTMVLGSLNAEERVAAFLLDVSSRYMKRGYSPNEFNLRMTREDIGSYLGMTLETVSRTLSKFHKRGLIEMQGRMV
RIVDFDGLHRL
>Mature_251_residues
MLTPVARPAAAAAPVHASSTWAPRQAAHCSTCAMRHLCMPQGLAPEALARLESVICTARPVRRGETLFREGDTFDNLYAV
RSGSLKTIATRHDGREQVTGLHLAGEALGLDGICDDAHPRTAVALEDSSVCVIPYSALKTLCSEAGTIQLRMHKLMSEQI
VRETSQTMVLGSLNAEERVAAFLLDVSSRYMKRGYSPNEFNLRMTREDIGSYLGMTLETVSRTLSKFHKRGLIEMQGRMV
RIVDFDGLHRL

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=226, Percent_Identity=42.4778761061947, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI1789756, Length=179, Percent_Identity=22.9050279329609, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27613; Mature: 27613

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPVARPAAAAAPVHASSTWAPRQAAHCSTCAMRHLCMPQGLAPEALARLESVICTARP
CCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
VRRGETLFREGDTFDNLYAVRSGSLKTIATRHDGREQVTGLHLAGEALGLDGICDDAHPR
CCCCHHHHHCCCCHHHEEEECCCCEEEEEECCCCHHHHHEEEECCHHCCCCCCCCCCCCC
TAVALEDSSVCVIPYSALKTLCSEAGTIQLRMHKLMSEQIVRETSQTMVLGSLNAEERVA
EEEEECCCCEEEEEHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHH
AFLLDVSSRYMKRGYSPNEFNLRMTREDIGSYLGMTLETVSRTLSKFHKRGLIEMQGRMV
HHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEE
RIVDFDGLHRL
EEEECCCCCCC
>Mature Secondary Structure
MLTPVARPAAAAAPVHASSTWAPRQAAHCSTCAMRHLCMPQGLAPEALARLESVICTARP
CCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
VRRGETLFREGDTFDNLYAVRSGSLKTIATRHDGREQVTGLHLAGEALGLDGICDDAHPR
CCCCHHHHHCCCCHHHEEEECCCCEEEEEECCCCHHHHHEEEECCHHCCCCCCCCCCCCC
TAVALEDSSVCVIPYSALKTLCSEAGTIQLRMHKLMSEQIVRETSQTMVLGSLNAEERVA
EEEEECCCCEEEEEHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHH
AFLLDVSSRYMKRGYSPNEFNLRMTREDIGSYLGMTLETVSRTLSKFHKRGLIEMQGRMV
HHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEE
RIVDFDGLHRL
EEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]