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The map label for this gene is adhA [H]

Identifier: 126446697

GI number: 126446697

Start: 160844

End: 161830

Strand: Direct

Name: adhA [H]

Synonym: BMA10247_A0189

Alternate gene names: 126446697

Gene position: 160844-161830 (Clockwise)

Preceding gene: 126445965

Following gene: 126446163

Centisome position: 6.84

GC content: 71.63

Gene sequence:

>987_bases
ATGCGCGCGATGGTATTCGACGGCGGCGCGCCGCGGCTGCGCGAAGCCGAGCTGCCGGACCCCGTGCCGGCGGCGGGGCA
ACTGCTGATCGACGTGCACGCGTGCGGCGTGTGCCGGACCGATCTGCACGTCGTCGACGGCGATCTGCGCGATCCGAAGC
GGCCGGTGATTCCGGGGCACGAGATCGTCGGCACGGTGGCCGCGCTCGGCGCGCTCGCGAAGGGTTTCACGATCGGCGAG
CGTGTCGGCGTGCCTTGGCTCGGGCGCACGTGCGGCCATTGCGCGTACTGCGCGAGCGGCCGCGAGAACCTGTGCGATGC
GCCCGGCTTCACCGGCTACACGATCGACGGCGGCTATGCGCAGCGCACGGTCGCCGACGCGCGCTTTTGCGTGCACGTGC
CGAGCCGCTACGACGATATTCATGCGGCGCCGCTGCTGTGCGCGGGTCTCATCGGCTACCGGACGCTGAAGATGGCCGGT
TCCGCGCGGCGCATCGGCCTGTACGGATTCGGCGCGGCCGCGCACCTCGTCGCGCAGGTCGCGCGTTTTCAGGGGCGCAC
CGTTTATGCGTTCACGCGCCCGGGCGACGCCGCCGCACAGCGGCTCGCGCGCCGGCTCGGCGCCGCGTGGGCGGGCGGCA
GCGACGAAGCCGCGCCCGAGCCGCTCGATGCGGCGCTGATCTTCGCATCGGTCGGCGCGCTCGTGCCGGCCGCGCTCGCG
GCGGTCGTGAAGGGCGGCGCCGTCGTGTGCGGTGGGATTCACATGTCGGACATTCCGTCGTTTTCGTACGATTTGTTGTG
GGGCGAGCGGCGGATCGTATCGGTCGCGAACCTGACGCGCGACGACGCGGCCGAATTCATGCGGATTGCGAACGACGTGC
CGCTCGACGTGGAGGCAACGCCGTATCCGCTCGCGCAGGCGAACCAGGCACTCGACGATCTGCGCGCCGGACGTCTGGCC
GGGGCGGCGGTGTTGACGATGCGCTAG

Upstream 100 bases:

>100_bases
ACTATCTGCGCGTGATCGCGATCAGGCGGGTGCGCGAACGGATCGTGTCGCACGCGCGCGCGGCGGACGAGGCGCATGCG
CGCCGTCCGGGAGCGCGTTG

Downstream 100 bases:

>100_bases
CGCCGGAGCGCGTGCGCGCCTGCGTGGCGGTTGCCGAGGGCATGCGGCGAGATGCGGCCGCGCCGCGTCGGTCGCCGGGA
ACGGAGGCGGGCCCGTCGCG

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRAMVFDGGAPRLREAELPDPVPAAGQLLIDVHACGVCRTDLHVVDGDLRDPKRPVIPGHEIVGTVAALGALAKGFTIGE
RVGVPWLGRTCGHCAYCASGRENLCDAPGFTGYTIDGGYAQRTVADARFCVHVPSRYDDIHAAPLLCAGLIGYRTLKMAG
SARRIGLYGFGAAAHLVAQVARFQGRTVYAFTRPGDAAAQRLARRLGAAWAGGSDEAAPEPLDAALIFASVGALVPAALA
AVVKGGAVVCGGIHMSDIPSFSYDLLWGERRIVSVANLTRDDAAEFMRIANDVPLDVEATPYPLAQANQALDDLRAGRLA
GAAVLTMR

Sequences:

>Translated_328_residues
MRAMVFDGGAPRLREAELPDPVPAAGQLLIDVHACGVCRTDLHVVDGDLRDPKRPVIPGHEIVGTVAALGALAKGFTIGE
RVGVPWLGRTCGHCAYCASGRENLCDAPGFTGYTIDGGYAQRTVADARFCVHVPSRYDDIHAAPLLCAGLIGYRTLKMAG
SARRIGLYGFGAAAHLVAQVARFQGRTVYAFTRPGDAAAQRLARRLGAAWAGGSDEAAPEPLDAALIFASVGALVPAALA
AVVKGGAVVCGGIHMSDIPSFSYDLLWGERRIVSVANLTRDDAAEFMRIANDVPLDVEATPYPLAQANQALDDLRAGRLA
GAAVLTMR
>Mature_328_residues
MRAMVFDGGAPRLREAELPDPVPAAGQLLIDVHACGVCRTDLHVVDGDLRDPKRPVIPGHEIVGTVAALGALAKGFTIGE
RVGVPWLGRTCGHCAYCASGRENLCDAPGFTGYTIDGGYAQRTVADARFCVHVPSRYDDIHAAPLLCAGLIGYRTLKMAG
SARRIGLYGFGAAAHLVAQVARFQGRTVYAFTRPGDAAAQRLARRLGAAWAGGSDEAAPEPLDAALIFASVGALVPAALA
AVVKGGAVVCGGIHMSDIPSFSYDLLWGERRIVSVANLTRDDAAEFMRIANDVPLDVEATPYPLAQANQALDDLRAGRLA
GAAVLTMR

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081918, Length=324, Percent_Identity=31.7901234567901, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082401, Length=300, Percent_Identity=28, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786518, Length=226, Percent_Identity=34.070796460177, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788073, Length=311, Percent_Identity=26.6881028938907, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787863, Length=205, Percent_Identity=27.3170731707317, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790045, Length=195, Percent_Identity=31.2820512820513, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=102, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=158, Percent_Identity=32.9113924050633, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=162, Percent_Identity=32.0987654320988, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=193, Percent_Identity=30.5699481865285, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=132, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=130, Percent_Identity=33.0769230769231, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=211, Percent_Identity=35.5450236966825, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323961, Length=160, Percent_Identity=39.375, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323729, Length=160, Percent_Identity=37.5, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=160, Percent_Identity=37.5, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=146, Percent_Identity=36.986301369863, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=186, Percent_Identity=32.258064516129, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=205, Percent_Identity=29.7560975609756, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34368; Mature: 34368

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMVFDGGAPRLREAELPDPVPAAGQLLIDVHACGVCRTDLHVVDGDLRDPKRPVIPGH
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCEECCCCEEECCCCCCCCCCCCCCH
EIVGTVAALGALAKGFTIGERVGVPWLGRTCGHCAYCASGRENLCDAPGFTGYTIDGGYA
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCHHHHCCCCCCCCCCCCCCEEEECCCHH
QRTVADARFCVHVPSRYDDIHAAPLLCAGLIGYRTLKMAGSARRIGLYGFGAAAHLVAQV
HHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHH
ARFQGRTVYAFTRPGDAAAQRLARRLGAAWAGGSDEAAPEPLDAALIFASVGALVPAALA
HHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AVVKGGAVVCGGIHMSDIPSFSYDLLWGERRIVSVANLTRDDAAEFMRIANDVPLDVEAT
HHHCCCEEEECCCCCCCCCCCCEEEEECCHHEEHHHHCCHHHHHHHHHHHCCCCCCCCCC
PYPLAQANQALDDLRAGRLAGAAVLTMR
CCCHHHHHHHHHHHHHHHHCCEEEEEEC
>Mature Secondary Structure
MRAMVFDGGAPRLREAELPDPVPAAGQLLIDVHACGVCRTDLHVVDGDLRDPKRPVIPGH
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCEECCCCEEECCCCCCCCCCCCCCH
EIVGTVAALGALAKGFTIGERVGVPWLGRTCGHCAYCASGRENLCDAPGFTGYTIDGGYA
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCHHHHCCCCCCCCCCCCCCEEEECCCHH
QRTVADARFCVHVPSRYDDIHAAPLLCAGLIGYRTLKMAGSARRIGLYGFGAAAHLVAQV
HHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHH
ARFQGRTVYAFTRPGDAAAQRLARRLGAAWAGGSDEAAPEPLDAALIFASVGALVPAALA
HHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AVVKGGAVVCGGIHMSDIPSFSYDLLWGERRIVSVANLTRDDAAEFMRIANDVPLDVEAT
HHHCCCEEEECCCCCCCCCCCCEEEEECCHHEEHHHHCCHHHHHHHHHHHCCCCCCCCCC
PYPLAQANQALDDLRAGRLAGAAVLTMR
CCCHHHHHHHHHHHHHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]