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The map label for this gene is mdh [H]

Identifier: 126446381

GI number: 126446381

Start: 447715

End: 448698

Strand: Reverse

Name: mdh [H]

Synonym: BMA10247_A0497

Alternate gene names: 126446381

Gene position: 448698-447715 (Counterclockwise)

Preceding gene: 126446456

Following gene: 126446777

Centisome position: 19.07

GC content: 66.67

Gene sequence:

>984_bases
ATGGCTAAGCCCGCAAAGCGCGTTGCCGTCACCGGCGCCGCAGGTCAGATCGCTTACTCACTGCTGTTTCGCATCGCGAA
CGGCGACCTGCTCGGCAAGGATCAGCCGGTCATCCTGCAACTGCTCGACCTCCCGCAAGCCCAGGCCGCCGTCAAAGGCG
TCGTGATGGAACTGGACGATTGCGCGTTCCCGCTGCTCGCGGGCGTCGTGATCACCGACGACCCGAAGGTCGCGTTCAAG
GACGCCGACGTCGCGCTGCTGGTGGGCGCGCGTCCGCGCTCGAAGGGCATGGAGCGCAAGGATCTGCTGTCGGCGAACGC
CGAGATCTTCACGGTCCAGGGCGCGGCGCTGAACGAAGTCGCGAGCCGCGACGTGAAGGTGCTGGTCGTCGGCAACCCGG
CGAACACGAACGCGTACATCGCGATGAAGTCGGCGCCGGATCTGCCGAAGAAGAACTTCACGGCGATGCTGCGCCTCGAC
CACAACCGCGCGCTGTCGCAGCTCGCCGCGAAGTCGGGCAAGCCGGTCGCGTCGATCGAGAAGCTCGCCGTGTGGGGCAA
CCACTCGCCGACGATGTACCCCGACTTCCGCTTCGCGACCGCCGAGGGCGAATCGCTGCTGAAGCTGATCAACGACGACG
TGTGGAACCGCGACACGTTCATCCCGACCGTCGGCAAGCGCGGCGCGGCGATCATCGAAGCGCGCGGCCTGTCGTCGGCG
GCGTCGGCGGCCAACGCGGCGATCGACCACGTGCGTGACTGGGTGCTCGGCACGAACGGCAAGTGGGTCACGATGGGCAT
CCCGTCGGACGGCTCGTACGGCATCCCCGAGGACATCATCTACGGCGTGCCGGTGATTTGCGAAAACGGCGAGTACAAGC
GCGTCGAGGGCCTGGAAATCGACGCGTTCTCGCGCGAGAAGATGGACGGCACGCTCGCCGAGCTGCTCGAGGAGCGCGAC
GGCGTCGCCCATCTGCTGAAGTAA

Upstream 100 bases:

>100_bases
GCCGCGAGTCCTCCGCCCTGCTTTAAAGCAACGCTTCGCGTAACGCGCATAGAATGGCGTTTTCCCTAGCGTCCCACGCT
CAATGTCCTGGAGATTTTCA

Downstream 100 bases:

>100_bases
CGCGCACGGCCGGGCCCGCCGCGTCGCGGCGCCCCGGCGGGCCGGCCCACGGGCATCGCGCCCGGCCGCCGGCCCCGAAT
CGTCCGATATCCGATTCGCA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDDCAFPLLAGVVITDDPKVAFK
DADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLD
HNRALSQLAAKSGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSA
ASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEIDAFSREKMDGTLAELLEERD
GVAHLLK

Sequences:

>Translated_327_residues
MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDDCAFPLLAGVVITDDPKVAFK
DADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLD
HNRALSQLAAKSGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSA
ASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEIDAFSREKMDGTLAELLEERD
GVAHLLK
>Mature_326_residues
AKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDDCAFPLLAGVVITDDPKVAFKD
ADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEVASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDH
NRALSQLAAKSGKPVASIEKLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSAA
SAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEIDAFSREKMDGTLAELLEERDG
VAHLLK

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family [H]

Homologues:

Organism=Homo sapiens, GI5174539, Length=332, Percent_Identity=54.2168674698795, Blast_Score=351, Evalue=5e-97,
Organism=Homo sapiens, GI89886456, Length=333, Percent_Identity=24.6246246246246, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17561064, Length=320, Percent_Identity=54.0625, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI32566798, Length=257, Percent_Identity=54.863813229572, Blast_Score=257, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI32566800, Length=170, Percent_Identity=48.8235294117647, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583394, Length=325, Percent_Identity=55.6923076923077, Blast_Score=336, Evalue=1e-92,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR010945
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 35016; Mature: 34884

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDD
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHECCCCHHHHHHHHHHHECCC
CAFPLLAGVVITDDPKVAFKDADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEV
HHHHHHCCEEEECCCCEEEECCCEEEEEECCCCCCCCCHHHHHCCCCEEEEECCCHHHHH
ASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDHNRALSQLAAKSGKPVASIE
HCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHE
KLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSA
EEEEECCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHH
ASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEI
HHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCHHHHCCCCEEECCCCEEEECCEEE
DAFSREKMDGTLAELLEERDGVAHLLK
CCCCCHHCCCHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
AKPAKRVAVTGAAGQIAYSLLFRIANGDLLGKDQPVILQLLDLPQAQAAVKGVVMELDD
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHECCCCHHHHHHHHHHHECCC
CAFPLLAGVVITDDPKVAFKDADVALLVGARPRSKGMERKDLLSANAEIFTVQGAALNEV
HHHHHHCCEEEECCCCEEEECCCEEEEEECCCCCCCCCHHHHHCCCCEEEEECCCHHHHH
ASRDVKVLVVGNPANTNAYIAMKSAPDLPKKNFTAMLRLDHNRALSQLAAKSGKPVASIE
HCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHE
KLAVWGNHSPTMYPDFRFATAEGESLLKLINDDVWNRDTFIPTVGKRGAAIIEARGLSSA
EEEEECCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHH
ASAANAAIDHVRDWVLGTNGKWVTMGIPSDGSYGIPEDIIYGVPVICENGEYKRVEGLEI
HHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCHHHHCCCCEEECCCCEEEECCEEE
DAFSREKMDGTLAELLEERDGVAHLLK
CCCCCHHCCCHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA