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The map label for this gene is gor [H]

Identifier: 126455173

GI number: 126455173

Start: 291333

End: 292694

Strand: Direct

Name: gor [H]

Synonym: BURPS1106A_0317

Alternate gene names: 126455173

Gene position: 291333-292694 (Clockwise)

Preceding gene: 126454268

Following gene: 126453241

Centisome position: 7.3

GC content: 69.97

Gene sequence:

>1362_bases
ATGGAATTCGACTACGATCTCTTTGTCATCGGCGCGGGCTCGGGCGGCGTGCGCCTGAGCCGCGTCGCGGCGTCCTACGG
CGCGCGCGTCGGCATCGCCGAGGAAGAGCGCATCGGCGGCACCTGCGTGCTGCGCGGCTGCATCCCGAAAAAGCTGCTCG
TCTACGCGTCGCATTACAGCCACGACGTCGAGGACGCCGCGGGCTATGGCTGGACCTTCGACATCGGCCTGTTTTCGTGG
CCGACGCTCATCGAGGCGAAGGACCGCGAGATCGCGCGCCTGAGCGGTATCTACGTCGATCTGCTGAACAAGTCGGGCGT
CGAGATCCATACGGGGCGCGCGACGCTCGTCGGCGCGCATACGGTCGACGTCGCGGGCCGGCGTGTCACCGCCCGGCACA
TCGCCGTCGCGACAGGCTCGCGGCCGGTGCTGCCGCCGATTCCCGGCATCGAGCACGCGATCACGTCGCGCGAGGCGCTC
GAGTTGCCCGAGCTGCCGCAGCGGATCGCGATCGTCGGCGGCGGCTACATCGCGGTCGAGTTCGCGGGCATCTTCAACGG
GCTCGGCGTCGATGTCGACCTGTTCTATCGCGGCGAGCAGATCCTGCGCGGCTTCGACGACGACGTGCGGCACGCGCTGC
ATGGCGAGATGACGAAGCAGGGTGTCGCCATCCATACGCGCGCGACGATCGAGGCGATCGAGCGCGGCGGCGACGGCGGG
TTGACGCTCAGGCTCGCCGAGGGCGCGTACGGGCCGTACGACGCGGTGCTGTATGCGACGGGGCGCGTCGCGAATGGCGA
CGGGCTCGGGCTCGAGGCGGTCGGGGTCGCGCGCGACGCGAACGGCGCGATCGAGGTCGACGCCTATTCGGCGACGACGG
TGCCGTCGATCCACGCGATCGGCGACGTCACCGCGCGCCCGCAACTGACGCCCGTCGCGACGCGCGACGGCATGCTGCTC
GCGGCGAACCTGTTCGGCGGCAAGCGGATCGCCGCCGATCATCGCTACGTTCCTTCCGCGGTGTTCAGCCAGCCGGAGAT
CGCGACGGTCGGGCTCACCGAGGCGCAAGCGCGCGCCGAGCTCGGCGCGCTCGACATCTACAAGACGTCGTTCCGCGCGC
TGCGGCACACGTTGTCCGGCCGCGACGAAAAGACGTTCATGAAGCTCGTCGTCGCGCGCGACAGCCAGCGCGTCGTCGGC
GCGCACATGGTCGGGCGCGACGCGGCGGAGATCATCCAGGGCATCGCGATCGCGATCCGGGCGGGCGCGACGAAGGCGCA
GTTCGACGAGACGGTCGGCATCCATCCAACCGCGGCCGAGGAGTTCGTCACGTTGCGGCAGAAGGAGCCGGACGACGCAT
GA

Upstream 100 bases:

>100_bases
GGCTGATGATTGCGCTGCATGACAGTACGCGCGCGCCGCGCCGCAAGAAATTCGAAAACTTGCTATCGTCCGGTCATCGG
GGTTTCGATCAGACGACGCT

Downstream 100 bases:

>100_bases
CGCCCGATTGGCGCGGTGCGCGACGGCTGGTGTGATGACGGGCGCGACGAACGGGCGGTTGCGGCGGGCGCGATAGGCGG
GCAGGCGGCGCGAGAGGCCG

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYSHDVEDAAGYGWTFDIGLFSW
PTLIEAKDREIARLSGIYVDLLNKSGVEIHTGRATLVGAHTVDVAGRRVTARHIAVATGSRPVLPPIPGIEHAITSREAL
ELPELPQRIAIVGGGYIAVEFAGIFNGLGVDVDLFYRGEQILRGFDDDVRHALHGEMTKQGVAIHTRATIEAIERGGDGG
LTLRLAEGAYGPYDAVLYATGRVANGDGLGLEAVGVARDANGAIEVDAYSATTVPSIHAIGDVTARPQLTPVATRDGMLL
AANLFGGKRIAADHRYVPSAVFSQPEIATVGLTEAQARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVG
AHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA

Sequences:

>Translated_453_residues
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYSHDVEDAAGYGWTFDIGLFSW
PTLIEAKDREIARLSGIYVDLLNKSGVEIHTGRATLVGAHTVDVAGRRVTARHIAVATGSRPVLPPIPGIEHAITSREAL
ELPELPQRIAIVGGGYIAVEFAGIFNGLGVDVDLFYRGEQILRGFDDDVRHALHGEMTKQGVAIHTRATIEAIERGGDGG
LTLRLAEGAYGPYDAVLYATGRVANGDGLGLEAVGVARDANGAIEVDAYSATTVPSIHAIGDVTARPQLTPVATRDGMLL
AANLFGGKRIAADHRYVPSAVFSQPEIATVGLTEAQARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVG
AHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA
>Mature_453_residues
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYSHDVEDAAGYGWTFDIGLFSW
PTLIEAKDREIARLSGIYVDLLNKSGVEIHTGRATLVGAHTVDVAGRRVTARHIAVATGSRPVLPPIPGIEHAITSREAL
ELPELPQRIAIVGGGYIAVEFAGIFNGLGVDVDLFYRGEQILRGFDDDVRHALHGEMTKQGVAIHTRATIEAIERGGDGG
LTLRLAEGAYGPYDAVLYATGRVANGDGLGLEAVGVARDANGAIEVDAYSATTVPSIHAIGDVTARPQLTPVATRDGMLL
AANLFGGKRIAADHRYVPSAVFSQPEIATVGLTEAQARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVG
AHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=40.7407407407407, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=35.3065539112051, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=35.3065539112051, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=35.3065539112051, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=35.3065539112051, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=35.3065539112051, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=36.3057324840764, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI291045266, Length=477, Percent_Identity=34.3815513626834, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=32.5581395348837, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=29.4759825327511, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=42.0560747663551, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=30.3097345132743, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI87082354, Length=452, Percent_Identity=30.3097345132743, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=29.646017699115, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=39.7777777777778, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=39.7777777777778, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=32.9787234042553, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71982272, Length=491, Percent_Identity=32.9938900203666, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=32.1663019693654, Blast_Score=198, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.7440347071584, Blast_Score=297, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=28.2937365010799, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=27.9569892473118, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=35.9574468085106, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=35.9574468085106, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=35.9574468085106, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=35.8050847457627, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=31.4285714285714, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48183; Mature: 48183

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYS
CCCCEEEEEEECCCCCEEHHHHHHHHCCEECCCHHHCCCCEEEEECCCCCEEEEEEHHCC
HDVEDAAGYGWTFDIGLFSWPTLIEAKDREIARLSGIYVDLLNKSGVEIHTGRATLVGAH
CCHHHHCCCCEEEEECCCCCCCEEECCCCHHHHHHCEEEEEECCCCCEEECCCEEEEEEE
TVDVAGRRVTARHIAVATGSRPVLPPIPGIEHAITSREALELPELPQRIAIVGGGYIAVE
EEECCCCEEEEEEEEEECCCCCCCCCCCCCHHHHCCHHHCCCCCCCCEEEEEECCEEEEE
FAGIFNGLGVDVDLFYRGEQILRGFDDDVRHALHGEMTKQGVAIHTRATIEAIERGGDGG
EEHHHCCCCCEEEEEECCHHHHCCCCHHHHHHHHCHHHHCCEEEEEHHHHHHHHCCCCCC
LTLRLAEGAYGPYDAVLYATGRVANGDGLGLEAVGVARDANGAIEVDAYSATTVPSIHAI
EEEEEECCCCCCCCEEEEEECEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCC
GDVTARPQLTPVATRDGMLLAANLFGGKRIAADHRYVPSAVFSQPEIATVGLTEAQARAE
CCCCCCCCCCEEECCCCEEEEEECCCCCEEECCCCCCCHHHCCCCCEEEEECCHHHHHHH
LGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVGAHMVGRDAAEIIQGIAIAIR
CCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCEEEHHHHCCCHHHHHHHHEEEEE
AGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA
CCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYS
CCCCEEEEEEECCCCCEEHHHHHHHHCCEECCCHHHCCCCEEEEECCCCCEEEEEEHHCC
HDVEDAAGYGWTFDIGLFSWPTLIEAKDREIARLSGIYVDLLNKSGVEIHTGRATLVGAH
CCHHHHCCCCEEEEECCCCCCCEEECCCCHHHHHHCEEEEEECCCCCEEECCCEEEEEEE
TVDVAGRRVTARHIAVATGSRPVLPPIPGIEHAITSREALELPELPQRIAIVGGGYIAVE
EEECCCCEEEEEEEEEECCCCCCCCCCCCCHHHHCCHHHCCCCCCCCEEEEEECCEEEEE
FAGIFNGLGVDVDLFYRGEQILRGFDDDVRHALHGEMTKQGVAIHTRATIEAIERGGDGG
EEHHHCCCCCEEEEEECCHHHHCCCCHHHHHHHHCHHHHCCEEEEEHHHHHHHHCCCCCC
LTLRLAEGAYGPYDAVLYATGRVANGDGLGLEAVGVARDANGAIEVDAYSATTVPSIHAI
EEEEEECCCCCCCCEEEEEECEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCC
GDVTARPQLTPVATRDGMLLAANLFGGKRIAADHRYVPSAVFSQPEIATVGLTEAQARAE
CCCCCCCCCCEEECCCCEEEEEECCCCCEEECCCCCCCHHHCCCCCEEEEECCHHHHHHH
LGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVGAHMVGRDAAEIIQGIAIAIR
CCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCEEEHHHHCCCHHHHHHHHEEEEE
AGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA
CCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]