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The map label for this gene is argG

Identifier: 126453241

GI number: 126453241

Start: 293287

End: 294627

Strand: Direct

Name: argG

Synonym: BURPS1106A_0319

Alternate gene names: 126453241

Gene position: 293287-294627 (Clockwise)

Preceding gene: 126455173

Following gene: 126451920

Centisome position: 7.35

GC content: 64.88

Gene sequence:

>1341_bases
ATGACCACGATTCTTGAAAATCTCCCGGCCGGCCAGAAGGTCGGCATTGCGTTCTCCGGCGGCCTCGACACGAGCGCCGC
GCTGCACTGGATGCGCATCAAGGGAGCCGTTCCTTACGCATACACGGCCAATCTCGGCCAGCCCGACGAAGACGACTACG
ACGCGATCCCGAAGCGCGCGATCCAGTACGGCGCCGAAGGCGCGCGCCTGATCGACTGCCGCGCGCAGCTCGTCGCCGAA
GGGATCGCGGCGCTCCAGTGCGGCGCGTTCCACATTTCGACGGCCGGCGTCACGTATTTCAATACGACCCCGATTGGCCG
CGCCGTGACGGGCACGATGCTCGTTGCCGCGATGAAGGAAGACGGCGTCAACATCTGGGGCGACGGCAGCACGTACAAGG
GCAACGACATCGAGCGCTTCTACCGCTATGGCCTGCTCGTCAATCCGGATCTGAAGATCTACAAGCCGTGGCTCGACCAG
CAGTTCATCGACGAGCTCGGCGGCCGCGCGGAAATGTCCGAATTCATGCGCCAGGCCGGTTTCGAGTACAAGATGTCGGC
CGAGAAGGCGTACTCGACCGATTCGAACCTGCTCGGCGCGACGCACGAGGCGAAGGATCTCGAGAGCCTCGAGAGCGGCA
TCAAGATCGTCAATCCGATCATGGGCGTCGCGTTCTGGCGCGACGACGTGAAGATCGACAAGGAAGAAGTGACGATCCGC
TTCGAAGAGGGGCGCCCGGTCGCGCTGAACGGCGTCGAGTACAAGGATGCGGTCGCGCTGCTGCTCGAGGCGAACCGGAT
CGGCGGGCGCCACGGCCTCGGGATGAGCGACCAGATCGAGAACCGGATCATCGAGGCGAAGAGCCGCGGCATCTATGAGG
CCCCGGGGCTCGCGCTGCTGTACATCGCATACGAGCGCCTCGTCACCGGCATCCACAACGAGGACACGATCGAGCAGTAC
CGCGAGAACGGCCGTCGTCTCGGCCGCCTGCTGTACCAGGGCCGCTGGTTCGACCCGCAGGCGATCATGCTGCGCGAGAC
GGCGCAGCGCTGGGTCGCGCGCGCGGTCACGGGCGAGGTGACGGTCGAGCTGCGCCGCGGCAACGATTATTCGATCATCG
GCACGCGCTCGCCCAACCTCACGTACCAGCCGGAGCGCCTGTCGATGGAGAAGGTGCAATCGATGTTCTCGCCGCGCGAC
CGGATCGGCCAACTGACGATGCGCAACCTCGACATCACCGATACGCGCGACAAGCTGCGCATCTATTCGCAAGTCGGCCT
GCTGGCGGCGGGCGAATCGTCGGCGCTGCCGAAGCTGAAGGAAGACGAGAGCGGCAACTGA

Upstream 100 bases:

>100_bases
CGGCCGGGGCCGCGCGCGAGACTTGCCTCATAATCGGGCACAGCCGATACTCTTGGATTCCGCGAAATTCCCCCTTCCAA
CTGATTGAACGGTTTTCGTC

Downstream 100 bases:

>100_bases
CGCGCCGGCGCGCGGATGCCCAGGCGTGCGCGCGGTGCCCGGTCCACGCCGGCGCGAGCCGGACGGCCGACACGAAGGAG
GAGGACGCCCGCGCCGCAAG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTTILENLPAGQKVGIAFSGGLDTSAALHWMRIKGAVPYAYTANLGQPDEDDYDAIPKRAIQYGAEGARLIDCRAQLVAE
GIAALQCGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQ
QFIDELGGRAEMSEFMRQAGFEYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIDKEEVTIR
FEEGRPVALNGVEYKDAVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQY
RENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEVTVELRRGNDYSIIGTRSPNLTYQPERLSMEKVQSMFSPRD
RIGQLTMRNLDITDTRDKLRIYSQVGLLAAGESSALPKLKEDESGN

Sequences:

>Translated_446_residues
MTTILENLPAGQKVGIAFSGGLDTSAALHWMRIKGAVPYAYTANLGQPDEDDYDAIPKRAIQYGAEGARLIDCRAQLVAE
GIAALQCGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQ
QFIDELGGRAEMSEFMRQAGFEYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIDKEEVTIR
FEEGRPVALNGVEYKDAVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQY
RENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEVTVELRRGNDYSIIGTRSPNLTYQPERLSMEKVQSMFSPRD
RIGQLTMRNLDITDTRDKLRIYSQVGLLAAGESSALPKLKEDESGN
>Mature_445_residues
TTILENLPAGQKVGIAFSGGLDTSAALHWMRIKGAVPYAYTANLGQPDEDDYDAIPKRAIQYGAEGARLIDCRAQLVAEG
IAALQCGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQQ
FIDELGGRAEMSEFMRQAGFEYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIDKEEVTIRF
EEGRPVALNGVEYKDAVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQYR
ENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEVTVELRRGNDYSIIGTRSPNLTYQPERLSMEKVQSMFSPRDR
IGQLTMRNLDITDTRDKLRIYSQVGLLAAGESSALPKLKEDESGN

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=408, Percent_Identity=29.4117647058824, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI16950633, Length=408, Percent_Identity=29.4117647058824, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1789563, Length=444, Percent_Identity=77.9279279279279, Blast_Score=733, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324514, Length=419, Percent_Identity=30.0715990453461, Blast_Score=156, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21358151, Length=424, Percent_Identity=29.2452830188679, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_BURM7 (A3MNB7)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001081753.1
- ProteinModelPortal:   A3MNB7
- SMR:   A3MNB7
- GeneID:   4892406
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_2224
- TIGR:   BMA10247_2224
- HOGENOM:   HBG289560
- OMA:   GGRKEMS
- ProtClustDB:   PRK05370
- BioCyc:   BMAL320389:BMA10247_2224-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00581
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 49698; Mature: 49567

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 43-43 BINDING 99-99 BINDING 129-129 BINDING 131-131 BINDING 131-131 BINDING 135-135 BINDING 135-135 BINDING 136-136 BINDING 136-136 BINDING 139-139 BINDING 192-192 BINDING 194-194 BINDING 201-201 BINDING 203-203 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTILENLPAGQKVGIAFSGGLDTSAALHWMRIKGAVPYAYTANLGQPDEDDYDAIPKRA
CCCCHHHCCCCCEEEEEEECCCCHHHHEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHH
IQYGAEGARLIDCRAQLVAEGIAALQCGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKE
HHHCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCCCHHHHHHHHHEEHHC
DGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQQFIDELGGRAEMSEFMRQAG
CCCEEECCCCCCCCCHHHHHHHCCCEECCCCEEECCCCCHHHHHHHCCHHHHHHHHHHCC
FEYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIDKEEVTIR
CCEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEECCEEEEEE
FEEGRPVALNGVEYKDAVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALL
ECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
YIAYERLVTGIHNEDTIEQYRENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEE
TVELRRGNDYSIIGTRSPNLTYQPERLSMEKVQSMFSPRDRIGQLTMRNLDITDTRDKLR
EEEEECCCCEEEEECCCCCCCCCHHHCCHHHHHHHHCCHHHHHHEEECCCCCCCCHHHHH
IYSQVGLLAAGESSALPKLKEDESGN
HHHHHCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTILENLPAGQKVGIAFSGGLDTSAALHWMRIKGAVPYAYTANLGQPDEDDYDAIPKRA
CCCHHHCCCCCEEEEEEECCCCHHHHEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHH
IQYGAEGARLIDCRAQLVAEGIAALQCGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKE
HHHCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCCCHHHHHHHHHEEHHC
DGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQQFIDELGGRAEMSEFMRQAG
CCCEEECCCCCCCCCHHHHHHHCCCEECCCCEEECCCCCHHHHHHHCCHHHHHHHHHHCC
FEYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIDKEEVTIR
CCEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEECCEEEEEE
FEEGRPVALNGVEYKDAVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALL
ECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
YIAYERLVTGIHNEDTIEQYRENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEE
TVELRRGNDYSIIGTRSPNLTYQPERLSMEKVQSMFSPRDRIGQLTMRNLDITDTRDKLR
EEEEECCCCEEEEECCCCCCCCCHHHCCHHHHHHHHCCHHHHHHEEECCCCCCCCHHHHH
IYSQVGLLAAGESSALPKLKEDESGN
HHHHHCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA