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The map label for this gene is hom [H]

Identifier: 126454983

GI number: 126454983

Start: 2254943

End: 2256271

Strand: Reverse

Name: hom [H]

Synonym: BURPS1106A_2270

Alternate gene names: 126454983

Gene position: 2256271-2254943 (Counterclockwise)

Preceding gene: 126451904

Following gene: 126454084

Centisome position: 56.57

GC content: 68.1

Gene sequence:

>1329_bases
ATGGAACCGATCAAAGTAGGCCTGTTGGGCTTCGGCACGGTGGGCGGCGGCACCTTCAAGGTGCTGCGCCGCAACCAGGA
GGAAATCAAGCGGCGCGCCGGGCGCGGCATCGAGATCGCGCGCGTCGCCGTGCGCAATCCCGCGAAGGCGCTCGCCGCGC
TCGACGGCGACGCGAACGGCGTGTCGATCGGCGACGATTTCAACGCGGTCGTCGACGATCCGTCGATCGCCATCGTCGCC
GAGATGATCGGCGGCACGGGCCTCGCGCGCGAGCTCGTGCTGCGCGCGATCGCGAACGGCAAGCATGTCGTGACCGCCAA
CAAGGCGCTGCTCGCCGTGCACGGCACCGAGATCTTCGAGGCGGCGCGCGCGAAGGGCGTGATGGTCGCGTTCGAGGCGG
CCGTCGCGGGCGGCATCCCGATCATCAAGGCGCTGCGCGAGGGGCTCACCGCGAACCGGATTCAGTACATCGCGGGCATC
ATCAACGGCACGACGAACTACATCCTGTCGGAGATGCGCGAGCGCGGGCTCGATTTCGCGACGGCGCTGAAGGCCGCGCA
GGAACTCGGCTACGCGGAAGCCGATCCGACCTTCGACATCGAGGGCGTCGACGCCGCGCACAAGGCGACGATCATGAGCG
CGATCGCGTTCGGCGTGCCGGTGCAGTTCGACCGCGCGTACGTCGAAGGCATCAGCCGGCTCGCCGCGACCGACATCAAA
TACGCGGAGGAACTCGGCTACCGGATCAAGCTGCTCGGCATCACGCGCCGCACCGAGCGCGGCATCGAGCTGCGCGTGCA
TCCGACGCTGATTCCGGCCAAGCGCCTGCTCGCGAACGTCGAGGGCGCGATGAACGCGGTCGTCGTGCACGGCGATGCGG
TCGGCACGACGCTGTACTACGGCAAGGGCGCGGGCGCCGAGCCGACGGCCTCGGCCGTCGTCGCGGATCTCGTCGACGTC
ACGCGCCTGCATACGGCGGACCCCGAGCACCGCGTGCCGCACCTCGCGTTCCAGCCGGACAGCCTGTCGAACACGCCGAT
CCTGCCGATCGAGGAGGTGACGAGCGGCTATTACCTGCGCCTGCGCGTCGCCGACCAGACGGGCGTGCTCGCCGACATCA
CGCGCATCCTCGCCGAATCGGGCATCTCGATCGACGCGCTGTTGCAGAAGGAATCGGAGCAGGTGGACGACGCGAACGGC
GAGACCGACATCATCCTCATCACGCACGAGACGGTCGAGAAGAACGTCAACGCGGCGATCGCGCGCATCGAATCGCTCGC
GACCGTCGTGTCGAAGGTCACGAAGCTGCGCATGGAAGCGCTCAACTGA

Upstream 100 bases:

>100_bases
CGATCGAGCGGATCGCACGCTTTCTCGACGGCTACCGGAAGCGCAACTCGGTCTGACCGGGGCGCGTTCCCCCTTTTTCA
TTCAATAGATCACACGCAGC

Downstream 100 bases:

>100_bases
GGACGACATGAATTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGTCACACGTTCTCCGACATCCTGCTCGGCGGCC
TCGCGAAGGACGGCGGGCTC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEIARVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVA
EMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRERGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISRLAATDIK
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAESGISIDALLQKESEQVDDANG
ETDIILITHETVEKNVNAAIARIESLATVVSKVTKLRMEALN

Sequences:

>Translated_442_residues
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEIARVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVA
EMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRERGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISRLAATDIK
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAESGISIDALLQKESEQVDDANG
ETDIILITHETVEKNVNAAIARIESLATVVSKVTKLRMEALN
>Mature_442_residues
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEIARVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVA
EMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRERGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISRLAATDIK
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAESGISIDALLQKESEQVDDANG
ETDIILITHETVEKNVNAAIARIESLATVVSKVTKLRMEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=253, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=159, Percent_Identity=32.0754716981132, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47004; Mature: 47004

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEIARVAVRNPAKALAALDGDANG
CCCEEEEEEEEECCCCCHHHHHHCCHHHHHHHCCCCCEEEHEECCCHHHHHHHCCCCCCC
VSIGDDFNAVVDDPSIAIVAEMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFE
EEECCCCCEEECCCCCEEHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRERGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISRLAATDIK
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADQTGVLADITRILAESGISIDALLQKESEQVDDANGETDIILITHETVEKNVNAAI
EEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHH
ARIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEIARVAVRNPAKALAALDGDANG
CCCEEEEEEEEECCCCCHHHHHHCCHHHHHHHCCCCCEEEHEECCCHHHHHHHCCCCCCC
VSIGDDFNAVVDDPSIAIVAEMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFE
EEECCCCCEEECCCCCEEHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRERGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISRLAATDIK
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADQTGVLADITRILAESGISIDALLQKESEQVDDANGETDIILITHETVEKNVNAAI
EEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHH
ARIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]