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The map label for this gene is hddC [H]

Identifier: 126454948

GI number: 126454948

Start: 3191659

End: 3192351

Strand: Reverse

Name: hddC [H]

Synonym: BURPS1106A_3276

Alternate gene names: 126454948

Gene position: 3192351-3191659 (Counterclockwise)

Preceding gene: 126453797

Following gene: 126453758

Centisome position: 80.04

GC content: 59.16

Gene sequence:

>693_bases
ATGAGAGAAGCGATCATCTTGGCCGGAGGGTTCGGTACGCGCTTGCGCACGGTCGTCTCCGACGTTCCCAAGCCGATGGC
GCCTATTGCCGGCAGGCCATTTCTTGAAATCCTCTTGACGCGTTTGAGCGAAAAGAAGTTTTCTCGGGTGGTCCTGTCCG
TTGGCTTCATGGCCGAGAAAATCATGAGCCATTTCGGTGATCGCTTCGCCGGAATCGACCTCGCGTATTCAGTCGAGAGC
GATCCGTTGGGTACGGGAGGCGCACTGAAGGCAACGTTGCCGTACTGCGAGGGCGACCACGCGTTCGTGTTCAACGGCGA
TACGTATCTGGATCTCGAAGTCGACGAACTGGACGACGGTTGGCAGACGGGCGGATTCCCGACGATCGTGGCCCGGCAGG
TGCCGGATACGGGGCGATACGGCCGCCTCGTCGTCGACGGCGGTCGGGTGACGGGTTTTGCCGAAAAGGGCGTTTCGGGA
CCGGGCTTGATCAACGCAGGTTGCTATGTCCTGCCGAAGGACATTCTTGCCGGCGAGACGGCGGAGACGTTCTCGTTCGA
AACCGATTTCATGTCGTCCGCAGTCCAGTCTCGCAGGTTCGACGTTTTCGTGACGCGTGGGCAGTTTATCGATATCGGCG
TTCCCGAGGACTTTTACCGCGCTCAAGACGAGCTTTCCGGAATCTGCAAGTGA

Upstream 100 bases:

>100_bases
GTCCCGTCGGCCGACACCCCGAAGATCCAGGAGGGGCACCTGGTTCTCGGACATATCGTTTGCGGGCTGGTCGAGCACTC
CATTTTCGGGAAGCAGTGAA

Downstream 100 bases:

>100_bases
AGAATCGCGCGTTGTTCCTGGATCGTGATGGGGTGATCAATCGCGACGACGGCTATGTTTTCGAGATCGAGAAATTTGTC
TTTCTGGACGGAATTTTCGA

Product: D-glycero-D-manno-heptose 1-phosphate guanosyltransferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MREAIILAGGFGTRLRTVVSDVPKPMAPIAGRPFLEILLTRLSEKKFSRVVLSVGFMAEKIMSHFGDRFAGIDLAYSVES
DPLGTGGALKATLPYCEGDHAFVFNGDTYLDLEVDELDDGWQTGGFPTIVARQVPDTGRYGRLVVDGGRVTGFAEKGVSG
PGLINAGCYVLPKDILAGETAETFSFETDFMSSAVQSRRFDVFVTRGQFIDIGVPEDFYRAQDELSGICK

Sequences:

>Translated_230_residues
MREAIILAGGFGTRLRTVVSDVPKPMAPIAGRPFLEILLTRLSEKKFSRVVLSVGFMAEKIMSHFGDRFAGIDLAYSVES
DPLGTGGALKATLPYCEGDHAFVFNGDTYLDLEVDELDDGWQTGGFPTIVARQVPDTGRYGRLVVDGGRVTGFAEKGVSG
PGLINAGCYVLPKDILAGETAETFSFETDFMSSAVQSRRFDVFVTRGQFIDIGVPEDFYRAQDELSGICK
>Mature_230_residues
MREAIILAGGFGTRLRTVVSDVPKPMAPIAGRPFLEILLTRLSEKKFSRVVLSVGFMAEKIMSHFGDRFAGIDLAYSVES
DPLGTGGALKATLPYCEGDHAFVFNGDTYLDLEVDELDDGWQTGGFPTIVARQVPDTGRYGRLVVDGGRVTGFAEKGVSG
PGLINAGCYVLPKDILAGETAETFSFETDFMSSAVQSRRFDVFVTRGQFIDIGVPEDFYRAQDELSGICK

Specific function: Bifunctional Enzyme Responsible For The Acetylation Of Glc-N-1-P To Give Glcnac-1-P And The Synthesis Of UDP-Glcnac. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=236, Percent_Identity=31.3559322033898, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI11761619, Length=236, Percent_Identity=31.3559322033898, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133931050, Length=235, Percent_Identity=32.3404255319149, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320148, Length=225, Percent_Identity=31.1111111111111, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355443, Length=235, Percent_Identity=31.4893617021277, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24644084, Length=235, Percent_Identity=31.4893617021277, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653912, Length=194, Percent_Identity=31.9587628865979, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 24954; Mature: 24954

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAIILAGGFGTRLRTVVSDVPKPMAPIAGRPFLEILLTRLSEKKFSRVVLSVGFMAEK
CCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMSHFGDRFAGIDLAYSVESDPLGTGGALKATLPYCEGDHAFVFNGDTYLDLEVDELDDG
HHHHHCCHHCCCEEEEEECCCCCCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCC
WQTGGFPTIVARQVPDTGRYGRLVVDGGRVTGFAEKGVSGPGLINAGCYVLPKDILAGET
CCCCCCCEEEEECCCCCCCCCEEEEECCEEEEHHHCCCCCCCEECCCCEEECHHHHCCCC
AETFSFETDFMSSAVQSRRFDVFVTRGQFIDIGVPEDFYRAQDELSGICK
CHHEECHHHHHHHHHHHCCEEEEEECCCEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MREAIILAGGFGTRLRTVVSDVPKPMAPIAGRPFLEILLTRLSEKKFSRVVLSVGFMAEK
CCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMSHFGDRFAGIDLAYSVESDPLGTGGALKATLPYCEGDHAFVFNGDTYLDLEVDELDDG
HHHHHCCHHCCCEEEEEECCCCCCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCC
WQTGGFPTIVARQVPDTGRYGRLVVDGGRVTGFAEKGVSGPGLINAGCYVLPKDILAGET
CCCCCCCEEEEECCCCCCCCCEEEEECCEEEEHHHCCCCCCCEECCCCEEECHHHHCCCC
AETFSFETDFMSSAVQSRRFDVFVTRGQFIDIGVPEDFYRAQDELSGICK
CHHEECHHHHHHHHHHHCCEEEEEECCCEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]