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The map label for this gene is pcaK [H]

Identifier: 126454908

GI number: 126454908

Start: 879680

End: 881134

Strand: Direct

Name: pcaK [H]

Synonym: BURPS1106A_0894

Alternate gene names: 126454908

Gene position: 879680-881134 (Clockwise)

Preceding gene: 126452512

Following gene: 126452736

Centisome position: 22.06

GC content: 74.02

Gene sequence:

>1455_bases
GTGTTTCGCCGCGGCGCGCCGCCGCATCGCCGCATCGAGCGCCGCGCGCCGGAGGCTCGCATGAGCGCCCGGCACGGCGG
TGCGCCGCTTGCGCTCGATATCGGCGCGACGCTCGACCACGGTCCGTTCACCGCGATGCAGCGCGTCGCGGTGCTGCTCG
CCGCGTTCGCGATCGTGCTCGACGGCTTCGACAGCCAGTTGATCGGCTTCGCGATTCCGGTGCTGATCAAGGAGTGGAGG
ATCACGCGCGACGCGTTCGCCCCCGCCGTCGCGGCGGGCCTGTTCGGGATGGGCGTCGGCAGCGCGTGCGCGGGCCTGTT
CGCGGACCGCTTCGGCCGGCGCTGGGCGATCATCGGCAGCGTGTTCGTGTTCGGCGCGGCTACCTGCGCGATCGGCTTCG
CGCCGAACGTGGCGACCATCGCCGCGCTGCGCTTCGTCGCGGGCCTCGGGATCGGCGGCGCGCTGCCCACCGCGACGACG
ATGACGGCCGAGTACACGCCCGCGCGCCGCCGCACGATGATGGTGACGGCGACGATCGTCTGCGTGCCGGCGGGCGGGAT
GCTCGCGGGCCTGTTCGCGCACGAGGTGCTGCCCGCGTACGGCTGGCGCAGCCTGTTCTGGCTCGGCGGCGCGCTGCCGC
TCGCGCTCGGCTTGCTGCTCGTGCGCGCGCTGCCCGAATCGCCGCGCTATCTCGCGCGCAATCCTGCGCGCTGGCGCGAG
CTCGGCGCGCTGCTCGCGCGCATGGGCCGGCCCGTCGCCGACGGCACCGCCTTCACCGATCTTGCCGAGGCGCGTGCGCA
CGAAGGGCAGCGGCGCGGTGTGCGTGCGCTGTTCTCGGCGGCCTACGCGCGCGACACGATCGCGTTGTGGTGCGCATTCT
GCATGTGCCTGCTCGCCGTCTACAGCGCATTCAGCTGGCTGCCGACGATGCTGACGTCGCAAGGCTTGAGCGTGTCGGTC
GCGGGTTCCGGGCTCACCGCATACAACCTCGGCGGCGTGCTGGGCGCGCTCGGCTGCGCGCTCGCGATCGGCCGTTTCGG
TTCGCGCTGGCCGCTCGCGTTCTGCTGTGCGGGCGGCGCGGCGAGCGCCGCGTGGCTGCTCGGCGTCGATGCCGGCAGCC
ACGCCGGCTGGCTGATCGTCGGCCTCGCCGCGCACGGCTTCTTCGTGAACGCGGTGCAGTCGACGATGTACGCGCTCTGC
ACGTTCATCTATCCGACGCCCGTGCGCGCGACGGGCACCGCCGGCGCCGTCGCGTTCGGCCGCGTCGGCGCGATCCTGAG
CGCGTTCGCGGGCGCGTACGTGATCTCGGCGGGCGGTGCGAACGCGTACCTGGCGATGCTCGCCGCCGCGATGGCGGTCG
TGCTCGTCGCGTTGCTCGCGCTGCGCCGGCACATTCCGCGGCTGCGCCGCGGCGGGCTGCCGGCGGCCGACGAGCTCGCG
CGCACCGCGCCCTGA

Upstream 100 bases:

>100_bases
CATCGCGAACGGTTTCGAAGAAAGCCGGCGCGGGGCGGGTCAGCGCGACGCGCCGATCCAGAGGACATTCAGGAGACGAC
ATGAAGCCCACCCCAACCCC

Downstream 100 bases:

>100_bases
CGCTTCGCCGCGCGTGCGCGCGGCGCTACAGCGTCGTGCGCACGTGCCAGAGTTCGGGGAACAGCACGACGTCGAGCATC
TTGCGCAGATACGGCGCGCC

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MFRRGAPPHRRIERRAPEARMSARHGGAPLALDIGATLDHGPFTAMQRVAVLLAAFAIVLDGFDSQLIGFAIPVLIKEWR
ITRDAFAPAVAAGLFGMGVGSACAGLFADRFGRRWAIIGSVFVFGAATCAIGFAPNVATIAALRFVAGLGIGGALPTATT
MTAEYTPARRRTMMVTATIVCVPAGGMLAGLFAHEVLPAYGWRSLFWLGGALPLALGLLLVRALPESPRYLARNPARWRE
LGALLARMGRPVADGTAFTDLAEARAHEGQRRGVRALFSAAYARDTIALWCAFCMCLLAVYSAFSWLPTMLTSQGLSVSV
AGSGLTAYNLGGVLGALGCALAIGRFGSRWPLAFCCAGGAASAAWLLGVDAGSHAGWLIVGLAAHGFFVNAVQSTMYALC
TFIYPTPVRATGTAGAVAFGRVGAILSAFAGAYVISAGGANAYLAMLAAAMAVVLVALLALRRHIPRLRRGGLPAADELA
RTAP

Sequences:

>Translated_484_residues
MFRRGAPPHRRIERRAPEARMSARHGGAPLALDIGATLDHGPFTAMQRVAVLLAAFAIVLDGFDSQLIGFAIPVLIKEWR
ITRDAFAPAVAAGLFGMGVGSACAGLFADRFGRRWAIIGSVFVFGAATCAIGFAPNVATIAALRFVAGLGIGGALPTATT
MTAEYTPARRRTMMVTATIVCVPAGGMLAGLFAHEVLPAYGWRSLFWLGGALPLALGLLLVRALPESPRYLARNPARWRE
LGALLARMGRPVADGTAFTDLAEARAHEGQRRGVRALFSAAYARDTIALWCAFCMCLLAVYSAFSWLPTMLTSQGLSVSV
AGSGLTAYNLGGVLGALGCALAIGRFGSRWPLAFCCAGGAASAAWLLGVDAGSHAGWLIVGLAAHGFFVNAVQSTMYALC
TFIYPTPVRATGTAGAVAFGRVGAILSAFAGAYVISAGGANAYLAMLAAAMAVVLVALLALRRHIPRLRRGGLPAADELA
RTAP
>Mature_484_residues
MFRRGAPPHRRIERRAPEARMSARHGGAPLALDIGATLDHGPFTAMQRVAVLLAAFAIVLDGFDSQLIGFAIPVLIKEWR
ITRDAFAPAVAAGLFGMGVGSACAGLFADRFGRRWAIIGSVFVFGAATCAIGFAPNVATIAALRFVAGLGIGGALPTATT
MTAEYTPARRRTMMVTATIVCVPAGGMLAGLFAHEVLPAYGWRSLFWLGGALPLALGLLLVRALPESPRYLARNPARWRE
LGALLARMGRPVADGTAFTDLAEARAHEGQRRGVRALFSAAYARDTIALWCAFCMCLLAVYSAFSWLPTMLTSQGLSVSV
AGSGLTAYNLGGVLGALGCALAIGRFGSRWPLAFCCAGGAASAAWLLGVDAGSHAGWLIVGLAAHGFFVNAVQSTMYALC
TFIYPTPVRATGTAGAVAFGRVGAILSAFAGAYVISAGGANAYLAMLAAAMAVVLVALLALRRHIPRLRRGGLPAADELA
RTAP

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=445, Percent_Identity=25.1685393258427, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI213021148, Length=412, Percent_Identity=25.7281553398058, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87081723, Length=338, Percent_Identity=31.6568047337278, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1786229, Length=418, Percent_Identity=25.8373205741627, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082231, Length=179, Percent_Identity=30.7262569832402, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082404, Length=205, Percent_Identity=24.8780487804878, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082159, Length=386, Percent_Identity=26.6839378238342, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788074, Length=376, Percent_Identity=23.936170212766, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788068, Length=431, Percent_Identity=22.5058004640371, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789207, Length=227, Percent_Identity=29.9559471365639, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=438, Percent_Identity=25.3424657534247, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922874, Length=408, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50334; Mature: 50334

Theoretical pI: Translated: 10.87; Mature: 10.87

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRRGAPPHRRIERRAPEARMSARHGGAPLALDIGATLDHGPFTAMQRVAVLLAAFAIVL
CCCCCCCHHHHHHHCCCHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DGFDSQLIGFAIPVLIKEWRITRDAFAPAVAAGLFGMGVGSACAGLFADRFGRRWAIIGS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHH
VFVFGAATCAIGFAPNVATIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEEEEEEEE
CVPAGGMLAGLFAHEVLPAYGWRSLFWLGGALPLALGLLLVRALPESPRYLARNPARWRE
EECCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHH
LGALLARMGRPVADGTAFTDLAEARAHEGQRRGVRALFSAAYARDTIALWCAFCMCLLAV
HHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSAFSWLPTMLTSQGLSVSVAGSGLTAYNLGGVLGALGCALAIGRFGSRWPLAFCCAGGA
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
ASAAWLLGVDAGSHAGWLIVGLAAHGFFVNAVQSTMYALCTFIYPTPVRATGTAGAVAFG
CCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RVGAILSAFAGAYVISAGGANAYLAMLAAAMAVVLVALLALRRHIPRLRRGGLPAADELA
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RTAP
CCCC
>Mature Secondary Structure
MFRRGAPPHRRIERRAPEARMSARHGGAPLALDIGATLDHGPFTAMQRVAVLLAAFAIVL
CCCCCCCHHHHHHHCCCHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DGFDSQLIGFAIPVLIKEWRITRDAFAPAVAAGLFGMGVGSACAGLFADRFGRRWAIIGS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHH
VFVFGAATCAIGFAPNVATIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEEEEEEEE
CVPAGGMLAGLFAHEVLPAYGWRSLFWLGGALPLALGLLLVRALPESPRYLARNPARWRE
EECCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHH
LGALLARMGRPVADGTAFTDLAEARAHEGQRRGVRALFSAAYARDTIALWCAFCMCLLAV
HHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSAFSWLPTMLTSQGLSVSVAGSGLTAYNLGGVLGALGCALAIGRFGSRWPLAFCCAGGA
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
ASAAWLLGVDAGSHAGWLIVGLAAHGFFVNAVQSTMYALCTFIYPTPVRATGTAGAVAFG
CCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RVGAILSAFAGAYVISAGGANAYLAMLAAAMAVVLVALLALRRHIPRLRRGGLPAADELA
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RTAP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]