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The map label for this gene is serS [H]

Identifier: 126454758

GI number: 126454758

Start: 2967913

End: 2969214

Strand: Reverse

Name: serS [H]

Synonym: BURPS1106A_3038

Alternate gene names: 126454758

Gene position: 2969214-2967913 (Counterclockwise)

Preceding gene: 126454407

Following gene: 126454884

Centisome position: 74.45

GC content: 67.43

Gene sequence:

>1302_bases
ATGCTCGACATCCAGTTGCTGCGCAAAGACCTCGACGGCGTCGCGAAACGCCTCGCCGATCGCGGCTACCCCCTCGACGT
CGCCGCGTTCTCCGCGCTCGAAGCGGAACGCCGGGCGATCCAGACCCGCACCGAAGAACTGCAGGCGCGCCGCAACAGCC
TGTCGAAGCAGATCGGCGCGATGAAGGGGCGGGGCGAGGACACGTCGGCGGTGATGGCCGAGGTGGGCGGCATCGGCGAC
GAGATGAAGGCCTCGGCGGTGAAGCTCGACGAGATTCAGGCGCGCCTGTCCGAGCTGATGCTGGAAATGCCGAACGTGCC
GCACGAGAGCGTGCCCGTCGGCCGCGACGAGACGGAGAACGTCGAAGTGCGCCGCTGGGGCGCGCCGCGCCAGTTCGATT
TCGACGTGAAGGACCACGTCGATGTGGGCACGCCGCTCGGCCTCGATTTCGAGACGGGCGCGAAGCTCTCCGGCGCGCGC
TTCACGGTGCTGCGCGGGCCGATCGCGCGCCTGCATCGCGCGCTCGCGCAGTTCATGCTGGACACGCATACGCAGCAGCA
CGGCTACAGCGAGACGTACACGCCTTACATCGTGAATCCGGACGTGCTGTACGGCACGGGCCAGTTGCCGAAGTTCGCGG
AGGACATGTTCCGCGTCGAGAAGGGCGGCGCGGAGAACACGGTCACGCAATACCTGATCTCGACCTCGGAGATTTCGCTG
ACGAACACGGTGCGCGATTCGATCGTCGAAGCGTCCGCGCTGCCGATCAAGCTGACCGCGCATTCGCCGTGCTTCCGCTC
GGAGGCGGGCTCGTACGGCCGCGACACGCGCGGGATGATCCGCCAGCACCAGTTCGACAAGGTCGAGATGGTGCAGATCG
TCGCGCCGGAAGCATCGTACGCGGCGCTCGACGAGATGGTCGGCCACGCGGAGGCAATCCTGCAGAAGCTCGAACTGCCG
TACCGCGTGGTCGCGCTATGCACGGGCGACATGGGTTTCTCGGCGGCGAAGACGTTCGACCTCGAGGTGTGGCTGCCCGC
GCAGAACACGTATCGGGAGATCTCGAGCTGCTCGAATACCGAATCGTTCCAGGCGCGCCGCATGCAGGCGCGGTTCCGCA
ACGCGCAGGGCAAGCCCGAGCTCGTGCATACGCTGAACGGCTCGGGCCTCGCGGTCGGCCGCACGCTCGTCGCGGTGCTG
GAGAACTACCAGAACGCCGACGGCTCGGTGACGGTGCCCGTCGCGTTGCGGCCTTACATGGGCGGCGTCGAGCGGATCGA
CGCGCCTTCGAGCGCGGCCTGA

Upstream 100 bases:

>100_bases
ACGGACGCCCGGTTTGCGGCATCGGCCGGTTGGGCGATGCCGTGGCGCGCGCGCGGTGCGTTAGAATTCTCCCCTTACAC
AACGATTCTCCTGTCCTCCC

Downstream 100 bases:

>100_bases
ACGGGCGTCCGAGCGGCTTCGAAAAGTTTTTGAAGAAAAAACTTGGAAGTCCGTGAAGAGTTGTTCTATAATCTTCGCTT
CGCCGGGACGACCTGCCGGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGAR
FTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
TNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQKLELP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPVALRPYMGGVERIDAPSSAA

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGAR
FTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
TNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQKLELP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPVALRPYMGGVERIDAPSSAA
>Mature_433_residues
MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGAR
FTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
TNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQKLELP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPVALRPYMGGVERIDAPSSAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=33.6886993603412, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI8923421, Length=418, Percent_Identity=29.6650717703349, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI225579074, Length=347, Percent_Identity=31.9884726224784, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=62.7039627039627, Blast_Score=558, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17539260, Length=467, Percent_Identity=32.1199143468951, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17542084, Length=352, Percent_Identity=30.3977272727273, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=33.0049261083744, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=384, Percent_Identity=29.9479166666667, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=33.1196581196581, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI17737985, Length=342, Percent_Identity=30.7017543859649, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47608; Mature: 47608

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETEN
HCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGARFTVLRGPIARLHRALAQFML
EEEEECCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEH
TNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASY
HHHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQKLELPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHCCCC
ESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPVALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GGVERIDAPSSAA
CCHHHCCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETEN
HCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGARFTVLRGPIARLHRALAQFML
EEEEECCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEH
TNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASY
HHHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQKLELPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHCCCC
ESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPVALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GGVERIDAPSSAA
CCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA