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The map label for this gene is ada [H]

Identifier: 126454639

GI number: 126454639

Start: 126408

End: 127502

Strand: Direct

Name: ada [H]

Synonym: BURPS1106A_0132

Alternate gene names: 126454639

Gene position: 126408-127502 (Clockwise)

Preceding gene: 126455405

Following gene: 126452165

Centisome position: 3.17

GC content: 69.95

Gene sequence:

>1095_bases
ATGAAGCAGCCACCCTATCCGACCGACGACGCGCGCTGGGCCGCGCTCGTCGCGCGCGACGTCGACGCCGACGGCGCGTT
CTGCTACGCGGTCAAGACGACCGGCGTGTTTTGCCGGCCTTCGTGCGCGTCGCGGCTGCCGAGGCGCGAGAACGTGTCGT
TTTTCGCCGACACGGGTGCCGCGCGCGCGGCCGGCTATCGCCCATGCAAGCGCTGTCGGCCCGAGGGATTGCCGCGCGAA
CTCGACATCGTCAACCGCGCGTGCGCGGTGCTCGACGCGCATCGTCAGGACCGCTTCACGCTCGCGCAACTGAGCGATGC
GGTTCACGTGAGCCCGTTTCATCTTCAGCGGCTGTTCAAGCGCGTCGTCGGCGTCTCGCCGCGCCAATATCAGGCCGCGC
AGCGCGGCGCCGCCTTGCGCGACGCGCTGCAAAGCGGTGCCGCCGTCACGCGCGCGGCCGTCGACGCGGGCTTCAACTCG
CCTTCTCGGCTCTATGAATCGGTGCCGCGCGAGCTCGGCATGTCGCCGTCCGCGTTCCGTCGCAAGGGGGCCGGCCTGAA
GATCGATTACGCGACGGCCGATACGCGCCTTGGCGTCGTGCTCGTCGCCGCGACGAGCAAGGGCATCTGCAAGATTGCAT
TCGGCGACGCCGCGGCGCCGCTCGTCGACGAACTCCGAACGGGGTTCGCGAATGCGCAGATTGCCGAGTCGCCCGAGCGG
ATCGCGCCGTTCATCGCGCAGATCGATGCGTATCTGAACGGCACTCGCCGGCGCTTCGAGCTGCCGCTCGATCTTGCCGC
GACCGAATTCCAGCAGCGCGTGTGGGATGCGTTGCGTCGGATTCCTTATGGCGAGACGCGCAGCTACACGCAGATCGCCG
AGGCGCTCGGCGCGCCGCGCGCGGTGCGGGCGGTCGCGAGCGCGTGCGCATCGAACCCGGTTGCGCTCGCGATTCCGTGC
CATCGCGTCGTGCAGAAAGGCGGCTCGCTCGCCGGCTACCGGTGGGGCTTGCCGCGCAAGGCGGCGCTCCTCGATGCCGA
GGCGCAGCGCGCGGCGGGCGAATCCGTCGAATCCGCCGTGGACCACGCAGCTTGA

Upstream 100 bases:

>100_bases
GGTATGACGATGGTTCGAATGAGAGCGCAAGAAACAGCGCGTATGCGAGCCGGGCGACGCCTACAGTGACAGGCATCTGT
TCCGACTTTGCGAGGTCAAC

Downstream 100 bases:

>100_bases
GCGCCGCCGTCGAACCGGCCGCCGTGCGGCCCGACAGCGTCGTGCTCGAGCTGCCGTTCAAATCGCCGTACGATTGGCCG
CGCGTGCTGCGCTTCTTCGC

Product: ADA regulatory protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGAARAAGYRPCKRCRPEGLPRE
LDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFKRVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNS
PSRLYESVPRELGMSPSAFRRKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPER
IAPFIAQIDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPRAVRAVASACASNPVALAIPC
HRVVQKGGSLAGYRWGLPRKAALLDAEAQRAAGESVESAVDHAA

Sequences:

>Translated_364_residues
MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGAARAAGYRPCKRCRPEGLPRE
LDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFKRVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNS
PSRLYESVPRELGMSPSAFRRKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPER
IAPFIAQIDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPRAVRAVASACASNPVALAIPC
HRVVQKGGSLAGYRWGLPRKAALLDAEAQRAAGESVESAVDHAA
>Mature_364_residues
MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGAARAAGYRPCKRCRPEGLPRE
LDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFKRVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNS
PSRLYESVPRELGMSPSAFRRKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPER
IAPFIAQIDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPRAVRAVASACASNPVALAIPC
HRVVQKGGSLAGYRWGLPRKAALLDAEAQRAAGESVESAVDHAA

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=171, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1788542, Length=352, Percent_Identity=48.2954545454545, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1787596, Length=88, Percent_Identity=46.5909090909091, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI115533068, Length=81, Percent_Identity=55.5555555555556, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115533070, Length=81, Percent_Identity=55.5555555555556, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320001, Length=87, Percent_Identity=40.2298850574713, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137554, Length=90, Percent_Identity=47.7777777777778, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 39263; Mature: 39263

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGA
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCEEECCHHHHHCCCCCCCCEEECCCC
ARAAGYRPCKRCRPEGLPRELDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFK
HHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHH
RVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNSPSRLYESVPRELGMSPSAFR
HHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHH
RKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPER
HCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCHHHCCHHH
IAPFIAQIDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPR
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHH
AVRAVASACASNPVALAIPCHRVVQKGGSLAGYRWGLPRKAALLDAEAQRAAGESVESAV
HHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
DHAA
HCCC
>Mature Secondary Structure
MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGA
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCEEECCHHHHHCCCCCCCCEEECCCC
ARAAGYRPCKRCRPEGLPRELDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFK
HHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHH
RVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNSPSRLYESVPRELGMSPSAFR
HHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHH
RKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPER
HCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCHHHCCHHH
IAPFIAQIDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPR
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHH
AVRAVASACASNPVALAIPCHRVVQKGGSLAGYRWGLPRKAALLDAEAQRAAGESVESAV
HHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
DHAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]