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The map label for this gene is ubiH [H]

Identifier: 126454612

GI number: 126454612

Start: 3313157

End: 3314350

Strand: Direct

Name: ubiH [H]

Synonym: BURPS1106A_3395

Alternate gene names: 126454612

Gene position: 3313157-3314350 (Clockwise)

Preceding gene: 126451784

Following gene: 126452924

Centisome position: 83.07

GC content: 74.62

Gene sequence:

>1194_bases
ATGACGACCGCCGCCTCCACGCCCGCTTTCGACTTCGACATCGCGATCGTCGGCGCCGGGCCGGTCGGGCTCGCGCTCGC
CGGCTGGCTCGCGCGCCGCAGCGCGACCCGCGCGCTGTCGGTCGCGCTCGTCGACGCGCGGGACCCCGACGCGAGCGAGA
ACGACCCGCGCGCGATCGCCGTATCGCAAGGCAGCCGGATGCTGCTCGACACGCTCGGCTGGCCGGGCGACGCCACGCCG
ATCGAGCACATCCACGTCTCGCAACGCGGCCACTTCGGCCGCACGCTGATCGAGCGCGACGAGCACGACCTTGCCGCGCT
CGGCTATGTCGCGCGCTACGGCTCGATCGTGCGGGCGCTCGCGCGCGCGGTGCGCGGCACGCCCGCGCGCTGGCTCACGT
CGACGTCCGCCCATTCGCCGGCACAGGACGCCGACGGCGTGACCATCGCGCTCGACACGCCGCAGGGCGCGCGCACGCTG
CGCGCGCGCGTGCTCGTCAACGCGGAGGGCGGCCTCTTCGACGAGCGCAAGCGCAAGCTGACCGACAGCGCGACGAACCG
CGACTACGGGCAAACGGCGCTCGTCGGCACCGTCACGGTGTCCGCGCCGCGCCCGCGCGTCGCGTGGGAGCGCTTCACCG
CCGAAGGCCCGCTCGCGCTGCTGCCGCTCGGCGGCCCGCAGCAGGCGGACTACGCGCTCGTCTGGTGCTGCGCGCCGGAC
GTCGCGCAACGCCGCGGCGCGCTGCCCGACGATGCGTTCCTGCAGGAGCTCGGCGCGACGTTCGGCACGCGGATGGGGCG
CTTCACGCGGATCGTCGGGCGCGCGGCGTTCCCGCTCGGGCTCGCCGCGGCACACACGCTCGTCGAAGGCCGGATCGCGA
TCGTCGGCAACGCCGCGCAAACCTTGCATCCGGTCGCGGGCCAGGGGCTGAACCTCGGGCTGCGCGACGCGCATACGCTT
GCCGAGACGCTGTCCGAGCACGGCGCGACGCCGCTCGCGCTCGCGACGTTCAACGCGCGCCGCGCGCTCGATCGGCGCAT
GACGATCGGCGCGACCGATACGCTCGCGCGCCTGTTCACCGTCGATTCGCGGCCGCTCGCGATGCTGCGCGGCGCGGCGC
TCACCGCGCTCGAATTCGTGCCGCCGCTGAAGACGGCGATCGCGCGACAGATGATGTTCGGGCAGCGGCGCTAG

Upstream 100 bases:

>100_bases
ACGAGATCGAGGCATTGATGCGCGACGCGCGGCCGGCGCCGCGCCCGCAGCCGTGATCCGCGCGCCCCTTCTTTCCACCG
AGACTCACGATTCACGAACG

Downstream 100 bases:

>100_bases
GCGCGCCGCAGGCGCACGCCGATGCGCGGCGGCTACCGCGCCTCGCGGGTACGCACGATGCGTCACCCCACCTTCACGCA
AGATTCATCGACGATTTGAC

Product: hypothetical protein

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQGSRMLLDTLGWPGDATP
IEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTL
RARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
VAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTL
AETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR

Sequences:

>Translated_397_residues
MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQGSRMLLDTLGWPGDATP
IEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTL
RARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
VAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTL
AETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
>Mature_396_residues
TTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQGSRMLLDTLGWPGDATPI
EHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTLR
ARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPDV
AQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLA
ETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=397, Percent_Identity=26.448362720403, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI32967307, Length=339, Percent_Identity=26.8436578171091, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1789274, Length=405, Percent_Identity=34.320987654321, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789273, Length=395, Percent_Identity=29.873417721519, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786883, Length=383, Percent_Identity=28.1984334203655, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321694, Length=467, Percent_Identity=23.1263383297645, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920760, Length=452, Percent_Identity=26.7699115044248, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 42206; Mature: 42074

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIA
CCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCEEE
VSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRAL
ECCCCEEEHHHCCCCCCCCCHHEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
ARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTLRARVLVNAEGGLFDERKRKL
HHHHCCCCHHHEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCHHHHHHH
TDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
HCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCH
VAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQ
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCHH
TLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFT
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHEECCCHHHHHHHHC
VDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIA
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCEEE
VSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRAL
ECCCCEEEHHHCCCCCCCCCHHEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
ARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTLRARVLVNAEGGLFDERKRKL
HHHHCCCCHHHEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCHHHHHHH
TDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
HCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCH
VAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQ
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCHH
TLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFT
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHEECCCHHHHHHHHC
VDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]