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The map label for this gene is pepP [H]

Identifier: 126451784

GI number: 126451784

Start: 3311703

End: 3313112

Strand: Direct

Name: pepP [H]

Synonym: BURPS1106A_3394

Alternate gene names: 126451784

Gene position: 3311703-3313112 (Clockwise)

Preceding gene: 126453753

Following gene: 126454612

Centisome position: 83.03

GC content: 72.48

Gene sequence:

>1410_bases
GTGATGAATCAGCCGACCGAACCCGCCCTCGCCCTCGACGTCTACCGCCAGCGCCGCGACCGCGTGCTGGCCTCGCTGCG
CGCGCAAGGCGGCGGCGTCGCGATCGTGCCCACCGCACCGGAAGTCCCGCGCAATCGCGACAGCGACTATCCGTACCGGC
ACGACAGCTACTTCTACTACCTGACGGGCTTCGCCGAGCCCGACGCGCTGCTCGTCCTCGACGCGTCGGCGGCCGGCGAC
GCGCCGCGCTCGATCCTGTTCTGCCGCGCGAAGAATCCCGAGCGAGAAATCTGGGAAGGGTTCCATTTCGGGCCCGAAGC
CGCGCGCGATGCGTTCGGCTTCGACGCCGCGTTCCCGTACGACGCGCTCGACGCCGAAATGCCGCGCATCGTCGCCGACG
CGCCCGCGCTCCACTACCGCTTCGGCGTGTCGGCCGCTTTCGACGCGCGCCTGAACGGCTGGCTCGACGCGGTGCGCGCG
CGTGCGCGCGCCGGCGTCGCCGCGCCGGGCGCCGCGTTCGATCTCGGGCCGCTCCTCGATGACATGCGGCTCGTCAAGGA
TGCGCACGAGCAGGCAACGATGCGCCGCGCGGCCGACATCTCCGCGCTCGCGCACCGCCGCGCGATGGCCGCGTGCCGCC
CCGGCATCCGCGAATACGAACTCGAGGCCGAGCTGCTCTACACGTTCCGCCGCCACGGCGCGCAATCGCCCGCATACGGC
TCGATCGTCGCGACGGGCGCGAACGCATGCGTGCTCCACTATCCGGCCGGCAACGCCGTCGTCGCCGACGGCGAGCTCGT
GCTGATCGACGCCGCGTGCGAGCTCGACGGCTACGCATCCGACATCACCCGCACGTTCCCGGCGAACGGCCGCTTCTCGG
GCCCGCAACGCGCGCTTTATGACATCGTGCTCGCCGCTCAGGAAGCGGCGATCGCGGCGACGCGCGCCGGCACGCAGTTC
GACGCGCCGCACGACGCGGCGGTGCGCGTGCTCGCGCAGGGCATGCTCGACACGGGGCTCGTGCCGAAGACGCGCTTCGC
GAGCGTCGACGACGTGATCGCCGAGCGTGCGTACACGCGCTTCTACATGCACCGCACCGGCCACTGGCTCGGCATGGACG
TGCACGACTGCGGCGACTACCGCGAGCGCGGCGCGCCGCGCGACGACGACGGCGCGCTGCCCTCGCGCGTGCTGCATCCG
GGCATGGCGCTCACGATCGAGCCGGGGCTGTACGTGCGCCCGGGCGAAGACGTGCCGCAGGCGTTCTGGAACATCGGCAT
CCGCATCGAGGACGACGCGTTCGTCACGCCGACGGGGTGCGAGCTGATCACGCGCGGCGTGCCGGTGGCGGCCGACGAGA
TCGAGGCATTGATGCGCGACGCGCGGCCGGCGCCGCGCCCGCAGCCGTGA

Upstream 100 bases:

>100_bases
AATCGCGGCGCGCGCCGCATCGCACTGCCGCACCGCGCCGCGTCCGCATGAGCGGCGCGCCATCCGTCGCGCGCGCCCCG
CGCGACGGCGCTACAATCGC

Downstream 100 bases:

>100_bases
TCCGCGCGCCCCTTCTTTCCACCGAGACTCACGATTCACGAACGATGACGACCGCCGCCTCCACGCCCGCTTTCGACTTC
GACATCGCGATCGTCGGCGC

Product: xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MMNQPTEPALALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGD
APRSILFCRAKNPEREIWEGFHFGPEAARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRA
RARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTQF
DAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERGAPRDDDGALPSRVLHP
GMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP

Sequences:

>Translated_469_residues
MMNQPTEPALALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGD
APRSILFCRAKNPEREIWEGFHFGPEAARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRA
RARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTQF
DAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERGAPRDDDGALPSRVLHP
GMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP
>Mature_469_residues
MMNQPTEPALALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGD
APRSILFCRAKNPEREIWEGFHFGPEAARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRA
RARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTQF
DAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERGAPRDDDGALPSRVLHP
GMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=463, Percent_Identity=30.6695464362851, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI149589008, Length=500, Percent_Identity=29.8, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI260593665, Length=319, Percent_Identity=35.423197492163, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI260593663, Length=331, Percent_Identity=31.7220543806647, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1789275, Length=446, Percent_Identity=42.8251121076233, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788728, Length=268, Percent_Identity=33.955223880597, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790282, Length=297, Percent_Identity=30.6397306397306, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=493, Percent_Identity=29.4117647058824, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=379, Percent_Identity=28.2321899736148, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=422, Percent_Identity=28.1990521327014, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321118, Length=444, Percent_Identity=29.0540540540541, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI19920384, Length=482, Percent_Identity=33.6099585062241, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21357079, Length=500, Percent_Identity=28.6, Blast_Score=181, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51077; Mature: 51077

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNQPTEPALALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
LTGFAEPDALLVLDASAAGDAPRSILFCRAKNPEREIWEGFHFGPEAARDAFGFDAAFPY
EEECCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHCCCCCCCCC
DALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRARARAGVAAPGAAFDLGPLLD
HHHCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
DMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALY
CEEEECCCEEEEEECCCCEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCHHHHHH
DIVLAAQEAAIAATRAGTQFDAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHH
FYMHRTGHWLGMDVHDCGDYRERGAPRDDDGALPSRVLHPGMALTIEPGLYVRPGEDVPQ
HHHHHCCCEEECCHHHCCCHHHCCCCCCCCCCCCHHHHCCCEEEEECCCEEECCCCHHHH
AFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP
HHHHCCEEECCCCEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMNQPTEPALALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
LTGFAEPDALLVLDASAAGDAPRSILFCRAKNPEREIWEGFHFGPEAARDAFGFDAAFPY
EEECCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHCCCCCCCCC
DALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRARARAGVAAPGAAFDLGPLLD
HHHCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
DMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALY
CEEEECCCEEEEEECCCCEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCHHHHHH
DIVLAAQEAAIAATRAGTQFDAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHH
FYMHRTGHWLGMDVHDCGDYRERGAPRDDDGALPSRVLHPGMALTIEPGLYVRPGEDVPQ
HHHHHCCCEEECCHHHCCCHHHCCCCCCCCCCCCHHHHCCCEEEEECCCEEECCCCHHHH
AFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP
HHHHCCEEECCCCEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]