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The map label for this gene is kbl [C]

Identifier: 126454564

GI number: 126454564

Start: 3177364

End: 3178683

Strand: Reverse

Name: kbl [C]

Synonym: BURPS1106A_3269

Alternate gene names: 126454564

Gene position: 3178683-3177364 (Counterclockwise)

Preceding gene: 126451807

Following gene: 126451542

Centisome position: 79.7

GC content: 70.08

Gene sequence:

>1320_bases
ATGGCACTGGGAGAGCATCTTCGCCAGCAACTGGCGGCGAAAGCGCTGAAACGGCAACTGGAGCGCGCCACCGATGCCGC
CGCGGCGCCCGGCGTGCCCGGCACGCCGGCTGCGCAGACCGCATCGGCGCGCAGCCGCTTCGAATCGATGCCGCAGTATC
AGCAGGTTCGGATCATGCGCGAGATGGGCGAGAAGCTGCGTGTCGACTCGCCGTTTTTCCGCGTGCACGATGGCGTGGCC
GGCGCGACGACGCAGATCGGCGGGCGCGAATACCTGAACTACGCGAACTACAACTACCTGGGCCTCGCGGGCGACCCCGC
CGTGTCGGCGCGCGCGAAGGACGCGATCGACCGCTACGGCACGTCCGCGTCGGCGAGCCGGATGGTGGCGGGCGAGCGGC
CCGTGCAGCGCGAGCTCGAGCGCGGCCTCGCGTCGTTCTACGAGACCGACGATTGCGTCGCGTTCGTGAGCGGCCACGCG
ACGAACGTGACTGTGATCGGCTCGCTGTTCGGCCCGGGCGACCTCATCGTGCACGATGCGCTCGCGCACAACAGCATCGT
GCAGGGCGCGCAGTTGAGCGGCGCGAAGCGCCTCGGCTTCGCGCACAACGACTGGCGCGCGCTCGACGCGCTGCTCGCGC
GCGTGCGGCGCGAATACCGGCACGTGCTCATCGCGATCGAAGGGCTCTACAGCATGGACGGCGATCTGCCGGACCTCGCG
CGCTTCGTCGAGATCAAGCAGCGTCACGGTGCGTTCCTGATGGTCGACGAGGCGCATTCGCTCGGCGTGCTCGGCCGGCA
CGGCAAGGGCATCCGCGAGCACTGCGGCGTGCCGTCCGCCGACGTCGATCTGTGGATGGGCACGCTGAGCAAGGTGCTCG
CCGGGTGCGGCGGCTTCATCGCCGGCTGCCAGCCGCTCATCGACATCCTGCGCCATCTCGCGCCGGGCTTCCTGTACAGC
GTCGGGCTGTCGCCCGTGCTCGCGGCCGCGTCGCTCGCCGCGCTCGAGCGCTTGCAGGCCGAGCCGCAGCGGATCGCGAC
GCTGCGCGAGCGCGGGCTGCAGTTCCTCACGCAGGCGCGCGAGGCCGGTCTCAACACGGGCACGAGCGAAGGCTACGCGG
TCGTGCCGGTCATCACCGGCAGCTCGCTGAAGGCCGCGCAATGGGCGAACGCGCTCTTCGACGAAGGCATCAACGTGCAG
CCGATCTTCTATCCGGCCGTCGAAGAGAAGGCCGCGCGGCTGCGTTTCTTCATCTGCTCGACGCACGAGCCCGAGCAGAT
CGAGCGCACGATCGCGGCGCTCGTGCGGCTCGCGCGCTGA

Upstream 100 bases:

>100_bases
GGCGCGTGGCAGTGGGCCGATTTTTCCGAGGCCTGAAACCGCGCTTTTTCAAAATGCACGGCGTAACATAGCGACTTTTC
GCGATACACCGAAGGAAGCA

Downstream 100 bases:

>100_bases
TCGCGGCGATGGCGACGGCACCTGCCGACGGCGAGCGCGGCGCGACGAACGACGCCGCGCCGCGCTCGTCGCCGTGGCGC
TTTCGCGCGGCCGCGGCGAG

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTPAAQTASARSRFESMPQYQQVRIMREMGEKLRVDSPFFRVHDGVA
GATTQIGGREYLNYANYNYLGLAGDPAVSARAKDAIDRYGTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHA
TNVTVIGSLFGPGDLIVHDALAHNSIVQGAQLSGAKRLGFAHNDWRALDALLARVRREYRHVLIAIEGLYSMDGDLPDLA
RFVEIKQRHGAFLMVDEAHSLGVLGRHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFIAGCQPLIDILRHLAPGFLYS
VGLSPVLAAASLAALERLQAEPQRIATLRERGLQFLTQAREAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQIERTIAALVRLAR

Sequences:

>Translated_439_residues
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTPAAQTASARSRFESMPQYQQVRIMREMGEKLRVDSPFFRVHDGVA
GATTQIGGREYLNYANYNYLGLAGDPAVSARAKDAIDRYGTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHA
TNVTVIGSLFGPGDLIVHDALAHNSIVQGAQLSGAKRLGFAHNDWRALDALLARVRREYRHVLIAIEGLYSMDGDLPDLA
RFVEIKQRHGAFLMVDEAHSLGVLGRHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFIAGCQPLIDILRHLAPGFLYS
VGLSPVLAAASLAALERLQAEPQRIATLRERGLQFLTQAREAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQIERTIAALVRLAR
>Mature_438_residues
ALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTPAAQTASARSRFESMPQYQQVRIMREMGEKLRVDSPFFRVHDGVAG
ATTQIGGREYLNYANYNYLGLAGDPAVSARAKDAIDRYGTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHAT
NVTVIGSLFGPGDLIVHDALAHNSIVQGAQLSGAKRLGFAHNDWRALDALLARVRREYRHVLIAIEGLYSMDGDLPDLAR
FVEIKQRHGAFLMVDEAHSLGVLGRHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFIAGCQPLIDILRHLAPGFLYSV
GLSPVLAAASLAALERLQAEPQRIATLRERGLQFLTQAREAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQP
IFYPAVEEKAARLRFFICSTHEPEQIERTIAALVRLAR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=33.2409972299169, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI7657118, Length=370, Percent_Identity=31.0810810810811, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=31.0055865921788, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=30.945558739255, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=28.4507042253521, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=28.4507042253521, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=28.4507042253521, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI5454084, Length=292, Percent_Identity=32.8767123287671, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=29.0140845070423, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=29.0140845070423, Blast_Score=132, Evalue=9e-31,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=35.5932203389831, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=31.1428571428571, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=32.7777777777778, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71994529, Length=404, Percent_Identity=29.4554455445545, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=456, Percent_Identity=28.0701754385965, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=358, Percent_Identity=30.4469273743017, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=32.404181184669, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=32.404181184669, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=398, Percent_Identity=29.3969849246231, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320438, Length=349, Percent_Identity=30.3724928366762, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=220, Percent_Identity=29.5454545454545, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24662918, Length=361, Percent_Identity=31.8559556786704, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=29.4765840220386, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137420, Length=454, Percent_Identity=27.5330396475771, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24653280, Length=299, Percent_Identity=29.0969899665552, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653276, Length=299, Percent_Identity=29.0969899665552, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653278, Length=299, Percent_Identity=29.0969899665552, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47477; Mature: 47346

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTPAAQTASARSRFESMPQYQQVRIMR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
EMGEKLRVDSPFFRVHDGVAGATTQIGGREYLNYANYNYLGLAGDPAVSARAKDAIDRYG
HHHHHHCCCCCHHHHHCCCCCCHHCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCC
TSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHATNVTVIGSLFGPGDLIVHDA
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHEEECCCCCCEEEEEECCCCCHHHHHHH
LAHNSIVQGAQLSGAKRLGFAHNDWRALDALLARVRREYRHVLIAIEGLYSMDGDLPDLA
HHHHHHHCCCHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RFVEIKQRHGAFLMVDEAHSLGVLGRHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFI
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AGCQPLIDILRHLAPGFLYSVGLSPVLAAASLAALERLQAEPQRIATLRERGLQFLTQAR
HHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQPIFYPAVEEKAARLRFFICS
HCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEEC
THEPEQIERTIAALVRLAR
CCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTPAAQTASARSRFESMPQYQQVRIMR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
EMGEKLRVDSPFFRVHDGVAGATTQIGGREYLNYANYNYLGLAGDPAVSARAKDAIDRYG
HHHHHHCCCCCHHHHHCCCCCCHHCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCC
TSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHATNVTVIGSLFGPGDLIVHDA
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHEEECCCCCCEEEEEECCCCCHHHHHHH
LAHNSIVQGAQLSGAKRLGFAHNDWRALDALLARVRREYRHVLIAIEGLYSMDGDLPDLA
HHHHHHHCCCHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RFVEIKQRHGAFLMVDEAHSLGVLGRHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFI
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AGCQPLIDILRHLAPGFLYSVGLSPVLAAASLAALERLQAEPQRIATLRERGLQFLTQAR
HHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQPIFYPAVEEKAARLRFFICS
HCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEEC
THEPEQIERTIAALVRLAR
CCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA