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The map label for this gene is tmk [H]

Identifier: 126454444

GI number: 126454444

Start: 2296343

End: 2296963

Strand: Reverse

Name: tmk [H]

Synonym: BURPS1106A_2320

Alternate gene names: 126454444

Gene position: 2296963-2296343 (Counterclockwise)

Preceding gene: 126452309

Following gene: 126452739

Centisome position: 57.59

GC content: 70.05

Gene sequence:

>621_bases
ATGGCGCGTGGCAAATTCATCACGTTCGAAGGGATCGACGGCGCGGGCAAGACCACGCATCTGCAGTGGTTCTGCGACCG
GCTCCAGGAAAGGCTCGGGCCGACCGGCAGGCACGTCGTCGTCACCCGCGAGCCGGGCGGCACGCAGCTCGGCGAGACGC
TGCGCGAGATTCTGCTGAACCAGCCGATGGACCTCGAGACCGAGGCGCTGCTGATGTTCGCCGGCCGGCGCGAGCATCTC
GCGCTCGTGATCGAGCCCGCGCTCGCGCGCGGCGATTGGGTCGTGTCGGACCGCTTCACCGATGCGACGTTCGCCTATCA
GGGCGGCGGCCGCGGGCTGCCGCGCGACAAGCTCGAGGCGCTCGAGCGCTGGGTGCAGGGCGGCTTCCAGCCGGATCTGA
CGGTGCTGTTCGACGTGCAGCCGCAGGTGGCGAGCGCGCGGCGCGGCGCCGTGCGGATGCCGGACAAGTTCGAGAGCGAA
TCGGACGCCTTCTTCGCGCGCACCCGCGCCGAGTACCTGCGCCGCGCGCACGAGGCGCCGCATCGTTTCGCGATCGTCGA
TTCGAGCGAGTCGATTCCGCAGATCCGCAGGCAGCTCGAAGGCGTGCTCGCCGCACTGTGA

Upstream 100 bases:

>100_bases
CGCGCTCTATTTCGTCGCGAGGGGCGACGGCACGAGCGTTTTCTCGGACACGCTCGGGGATCACAACAAGGCCGTGGACA
AATACATACGAGGTCAATGA

Downstream 100 bases:

>100_bases
CGAAAGGAAGACGCGAACGATGATCTATCCGTGGCAGACCGACGACTGGAACCGCCTGCAGGCGCTGCGCGCGCATTGGC
CGCACGCGCTGCTGCTGTAC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MARGKFITFEGIDGAGKTTHLQWFCDRLQERLGPTGRHVVVTREPGGTQLGETLREILLNQPMDLETEALLMFAGRREHL
ALVIEPALARGDWVVSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVQPQVASARRGAVRMPDKFESE
SDAFFARTRAEYLRRAHEAPHRFAIVDSSESIPQIRRQLEGVLAAL

Sequences:

>Translated_206_residues
MARGKFITFEGIDGAGKTTHLQWFCDRLQERLGPTGRHVVVTREPGGTQLGETLREILLNQPMDLETEALLMFAGRREHL
ALVIEPALARGDWVVSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVQPQVASARRGAVRMPDKFESE
SDAFFARTRAEYLRRAHEAPHRFAIVDSSESIPQIRRQLEGVLAAL
>Mature_205_residues
ARGKFITFEGIDGAGKTTHLQWFCDRLQERLGPTGRHVVVTREPGGTQLGETLREILLNQPMDLETEALLMFAGRREHLA
LVIEPALARGDWVVSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVQPQVASARRGAVRMPDKFESES
DAFFARTRAEYLRRAHEAPHRFAIVDSSESIPQIRRQLEGVLAAL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=180, Percent_Identity=45.5555555555556, Blast_Score=135, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23129; Mature: 22997

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARGKFITFEGIDGAGKTTHLQWFCDRLQERLGPTGRHVVVTREPGGTQLGETLREILLN
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHC
QPMDLETEALLMFAGRREHLALVIEPALARGDWVVSDRFTDATFAYQGGGRGLPRDKLEA
CCCCCCHHHHHEECCCCCCEEEEEECCCCCCCEEEECCCCCCEEEECCCCCCCCHHHHHH
LERWVQGGFQPDLTVLFDVQPQVASARRGAVRMPDKFESESDAFFARTRAEYLRRAHEAP
HHHHHHCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
HRFAIVDSSESIPQIRRQLEGVLAAL
CEEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARGKFITFEGIDGAGKTTHLQWFCDRLQERLGPTGRHVVVTREPGGTQLGETLREILLN
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHC
QPMDLETEALLMFAGRREHLALVIEPALARGDWVVSDRFTDATFAYQGGGRGLPRDKLEA
CCCCCCHHHHHEECCCCCCEEEEEECCCCCCCEEEECCCCCCEEEECCCCCCCCHHHHHH
LERWVQGGFQPDLTVLFDVQPQVASARRGAVRMPDKFESESDAFFARTRAEYLRRAHEAP
HHHHHHCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
HRFAIVDSSESIPQIRRQLEGVLAAL
CEEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA