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The map label for this gene is alkJ [H]

Identifier: 126453931

GI number: 126453931

Start: 212451

End: 214094

Strand: Direct

Name: alkJ [H]

Synonym: BURPS1106A_0228

Alternate gene names: 126453931

Gene position: 212451-214094 (Clockwise)

Preceding gene: 126454046

Following gene: 126453483

Centisome position: 5.33

GC content: 69.16

Gene sequence:

>1644_bases
ATGCAGTACGACTACATCATCGTCGGAGGCGGCTCGGGGGGCGCGAGTCTCGCGGGGCGTCTCGCCGACGCGTGCCCGGA
CGCGACGATCGCGCTGATCGAGGCGGGCGGCCACACCGAACGCAATCTGCTCGTCAACATGCCGGTGGGGATCGCCGCGC
TCGTGCCGTTCAAGCTCGGCACGAACTACGGCTACGAAACGGTGCCGCAGCCCGGCCTCGGCGGGCGCCGCGGCTATCAG
CCCCGCGGCCGCGGGCTCGGCGGCTCGAGCGCGATCAACGCGATGATCTACACGCGCGGCCATCCGCTCGATTATGACGA
ATGGGAGCAGCTCGGCTGCACCGGCTGGGGCTGGCGCGACGTGCTGCCGTATTTCCGGCGCGCCGAAGGCAACGCGCGCG
GCGCGAACGAATGGCACGGCGCCGACGGCCCGCTCACGGTATCCGATCTGCGCTTTCGTAATCCGTTCTCCGAACGATTC
ATCGCGGCCGCGCACGAGGCCGGCTATCCGCTGAACGACGATTTCAACGGCGAGCATCAGGAGGGCGTGGGCTTCTACCA
GGTCACGCATCGCGACGGCTCGCGCTGCAGCGTCGCGCGCGCCTACGTGTACGGCCGCACGCGGCCGAACCTGCACGTGA
TCGTCGACGCGACGGTGCTGCGCGTCGTGTTCGACGGCAAGCGCGCGACGGGCGTCGAGTTCGCGCGCGCCGGGCGCACC
GAGCAGCTTGCCGCGCGCGCGGAAGTGATTCTGTCCGCCGGCGCGTTCAATACGCCGCAATTGCTGATGTGCTCGGGCGT
CGGCCCCGCCGCGCAACTGCGCCGGCACGGCGTCGCGCTCGTGCACGATGCGCCCGACGTCGGCGAGAACCTGATCGATC
ACATCGATTTCATCATCAACAAGCGCGTGAATTCGTCGGAGCTCGTCGGCATCTGCATGCGCGGCATCGCGAAGATGACG
CCCGCGCTGTTCAGCTATCTGTCCGGGCGTCGCGGGATGATGACGAGCAATGTCGCGGAGGCGGGCGGCTTCATCAAGAG
CGAACCGGGGCTCGATCGTCCCGATCTGCAATTGCACTTCTGCACCGCGCTCGTCGACGATCACAACCGCAACATGCACT
GGGGCTTCGGCTATTCGCTGCACGTGTGCGCGCTGCGGCCGAAGAGCCGCGGCAACGTCGCGCTCGCAAGCGGCGACGCG
CGCGTCGCGCCGCTCATCGATCCGCGCTTCTTCAGCGACGAACGCGATCTCGACCTGCTCGTGACGGGCGCGAAGGCGAT
GCGCAGGATCCTCTGCGCCGCGCCGCTCGCGTCGCAGGGCGGGCGCGAGCTGTATACCGATCCGGGCGACACCGATGCGC
AATTGCGCGCGGCGATCGTCGCGCATGCGGACACGATCTACCACCCGGTCGGCACGTGCCGGATGGGCACCGATGCGCGC
GCGGTCGTCGATCCGCAATTGCGCGTGAAAGGGGTGGACGGGCTGCGGGTGGTCGATGCTTCGGTGATGCCGACGCTCAT
CGGCGGCAACACGAACGCGCCGACCGTGATGATCGCCGAGCGCGCGGCGGATTTCATCGTGGCCGCGCGCAACGGCCAGG
CCGCGCCCACGCGCGAGCGAGTCGCGGCGACGCACGGCGGCTGA

Upstream 100 bases:

>100_bases
TTTTGCGTTCCTAAAATGCGCGAACATGACAGACCTGATCCGGCCGCCTCGATGGCGGTTTCGGCCGCCATCGCGTGGAA
GACAAACAGGGAGACGTGAC

Downstream 100 bases:

>100_bases
TGCGCGCGGCCGCCGTGCGAGGCGCGCATGGCGCGAACGTCAGGCGAAGGTGTCGACCATCCCGACGGCGCGTCGCGCCG
CACCGCCGGAAGATGCTGCT

Product: GMC family oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MQYDYIIVGGGSGGASLAGRLADACPDATIALIEAGGHTERNLLVNMPVGIAALVPFKLGTNYGYETVPQPGLGGRRGYQ
PRGRGLGGSSAINAMIYTRGHPLDYDEWEQLGCTGWGWRDVLPYFRRAEGNARGANEWHGADGPLTVSDLRFRNPFSERF
IAAAHEAGYPLNDDFNGEHQEGVGFYQVTHRDGSRCSVARAYVYGRTRPNLHVIVDATVLRVVFDGKRATGVEFARAGRT
EQLAARAEVILSAGAFNTPQLLMCSGVGPAAQLRRHGVALVHDAPDVGENLIDHIDFIINKRVNSSELVGICMRGIAKMT
PALFSYLSGRRGMMTSNVAEAGGFIKSEPGLDRPDLQLHFCTALVDDHNRNMHWGFGYSLHVCALRPKSRGNVALASGDA
RVAPLIDPRFFSDERDLDLLVTGAKAMRRILCAAPLASQGGRELYTDPGDTDAQLRAAIVAHADTIYHPVGTCRMGTDAR
AVVDPQLRVKGVDGLRVVDASVMPTLIGGNTNAPTVMIAERAADFIVAARNGQAAPTRERVAATHGG

Sequences:

>Translated_547_residues
MQYDYIIVGGGSGGASLAGRLADACPDATIALIEAGGHTERNLLVNMPVGIAALVPFKLGTNYGYETVPQPGLGGRRGYQ
PRGRGLGGSSAINAMIYTRGHPLDYDEWEQLGCTGWGWRDVLPYFRRAEGNARGANEWHGADGPLTVSDLRFRNPFSERF
IAAAHEAGYPLNDDFNGEHQEGVGFYQVTHRDGSRCSVARAYVYGRTRPNLHVIVDATVLRVVFDGKRATGVEFARAGRT
EQLAARAEVILSAGAFNTPQLLMCSGVGPAAQLRRHGVALVHDAPDVGENLIDHIDFIINKRVNSSELVGICMRGIAKMT
PALFSYLSGRRGMMTSNVAEAGGFIKSEPGLDRPDLQLHFCTALVDDHNRNMHWGFGYSLHVCALRPKSRGNVALASGDA
RVAPLIDPRFFSDERDLDLLVTGAKAMRRILCAAPLASQGGRELYTDPGDTDAQLRAAIVAHADTIYHPVGTCRMGTDAR
AVVDPQLRVKGVDGLRVVDASVMPTLIGGNTNAPTVMIAERAADFIVAARNGQAAPTRERVAATHGG
>Mature_547_residues
MQYDYIIVGGGSGGASLAGRLADACPDATIALIEAGGHTERNLLVNMPVGIAALVPFKLGTNYGYETVPQPGLGGRRGYQ
PRGRGLGGSSAINAMIYTRGHPLDYDEWEQLGCTGWGWRDVLPYFRRAEGNARGANEWHGADGPLTVSDLRFRNPFSERF
IAAAHEAGYPLNDDFNGEHQEGVGFYQVTHRDGSRCSVARAYVYGRTRPNLHVIVDATVLRVVFDGKRATGVEFARAGRT
EQLAARAEVILSAGAFNTPQLLMCSGVGPAAQLRRHGVALVHDAPDVGENLIDHIDFIINKRVNSSELVGICMRGIAKMT
PALFSYLSGRRGMMTSNVAEAGGFIKSEPGLDRPDLQLHFCTALVDDHNRNMHWGFGYSLHVCALRPKSRGNVALASGDA
RVAPLIDPRFFSDERDLDLLVTGAKAMRRILCAAPLASQGGRELYTDPGDTDAQLRAAIVAHADTIYHPVGTCRMGTDAR
AVVDPQLRVKGVDGLRVVDASVMPTLIGGNTNAPTVMIAERAADFIVAARNGQAAPTRERVAATHGG

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=537, Percent_Identity=41.7132216014898, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI1786503, Length=537, Percent_Identity=40.9683426443203, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17532301, Length=549, Percent_Identity=37.8870673952641, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24642042, Length=573, Percent_Identity=38.5689354275742, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI45551458, Length=577, Percent_Identity=37.6083188908146, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI45549471, Length=577, Percent_Identity=37.6083188908146, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24642048, Length=583, Percent_Identity=37.7358490566038, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24642059, Length=575, Percent_Identity=36.5217391304348, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24642055, Length=577, Percent_Identity=35.8752166377816, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24650267, Length=586, Percent_Identity=35.6655290102389, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24642037, Length=575, Percent_Identity=36.3478260869565, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24642035, Length=573, Percent_Identity=36.1256544502618, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24642039, Length=583, Percent_Identity=36.8782161234991, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI17137792, Length=566, Percent_Identity=33.7455830388693, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI18859995, Length=574, Percent_Identity=35.3658536585366, Blast_Score=272, Evalue=5e-73,
Organism=Drosophila melanogaster, GI18859993, Length=576, Percent_Identity=33.5069444444444, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24642051, Length=577, Percent_Identity=29.9826689774697, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=29.3103448275862, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24642057, Length=595, Percent_Identity=29.5798319327731, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 58719; Mature: 58719

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYDYIIVGGGSGGASLAGRLADACPDATIALIEAGGHTERNLLVNMPVGIAALVPFKLG
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCEEEEEEEEEC
TNYGYETVPQPGLGGRRGYQPRGRGLGGSSAINAMIYTRGHPLDYDEWEQLGCTGWGWRD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEECCCCCCHHHHHHCCCCCCCHHH
VLPYFRRAEGNARGANEWHGADGPLTVSDLRFRNPFSERFIAAAHEAGYPLNDDFNGEHQ
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
EGVGFYQVTHRDGSRCSVARAYVYGRTRPNLHVIVDATVLRVVFDGKRATGVEFARAGRT
CCCEEEEEECCCCCCEEEEEEEEEECCCCCEEEEEEEEEEEEEECCCCCCCCHHHHCCCH
EQLAARAEVILSAGAFNTPQLLMCSGVGPAAQLRRHGVALVHDAPDVGENLIDHIDFIIN
HHHHHHHHHEEECCCCCCCCEEEECCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
KRVNSSELVGICMRGIAKMTPALFSYLSGRRGMMTSNVAEAGGFIKSEPGLDRPDLQLHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEE
CTALVDDHNRNMHWGFGYSLHVCALRPKSRGNVALASGDARVAPLIDPRFFSDERDLDLL
EEEECCCCCCCEEEECCCEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEE
VTGAKAMRRILCAAPLASQGGRELYTDPGDTDAQLRAAIVAHADTIYHPVGTCRMGTDAR
EECHHHHHHHHHHCCHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCC
AVVDPQLRVKGVDGLRVVDASVMPTLIGGNTNAPTVMIAERAADFIVAARNGQAAPTRER
EEECCCEEEECCCCEEEECCCCCCEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCHHH
VAATHGG
HHCCCCC
>Mature Secondary Structure
MQYDYIIVGGGSGGASLAGRLADACPDATIALIEAGGHTERNLLVNMPVGIAALVPFKLG
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCEEEEEEEEEC
TNYGYETVPQPGLGGRRGYQPRGRGLGGSSAINAMIYTRGHPLDYDEWEQLGCTGWGWRD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEECCCCCCHHHHHHCCCCCCCHHH
VLPYFRRAEGNARGANEWHGADGPLTVSDLRFRNPFSERFIAAAHEAGYPLNDDFNGEHQ
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
EGVGFYQVTHRDGSRCSVARAYVYGRTRPNLHVIVDATVLRVVFDGKRATGVEFARAGRT
CCCEEEEEECCCCCCEEEEEEEEEECCCCCEEEEEEEEEEEEEECCCCCCCCHHHHCCCH
EQLAARAEVILSAGAFNTPQLLMCSGVGPAAQLRRHGVALVHDAPDVGENLIDHIDFIIN
HHHHHHHHHEEECCCCCCCCEEEECCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
KRVNSSELVGICMRGIAKMTPALFSYLSGRRGMMTSNVAEAGGFIKSEPGLDRPDLQLHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEE
CTALVDDHNRNMHWGFGYSLHVCALRPKSRGNVALASGDARVAPLIDPRFFSDERDLDLL
EEEECCCCCCCEEEECCCEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEE
VTGAKAMRRILCAAPLASQGGRELYTDPGDTDAQLRAAIVAHADTIYHPVGTCRMGTDAR
EECHHHHHHHHHHCCHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCC
AVVDPQLRVKGVDGLRVVDASVMPTLIGGNTNAPTVMIAERAADFIVAARNGQAAPTRER
EEECCCEEEECCCCEEEECCCCCCEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCHHH
VAATHGG
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]