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The map label for this gene is hemD [H]

Identifier: 126453804

GI number: 126453804

Start: 1059647

End: 1061626

Strand: Direct

Name: hemD [H]

Synonym: BURPS1106A_1078

Alternate gene names: 126453804

Gene position: 1059647-1061626 (Clockwise)

Preceding gene: 126455102

Following gene: 126451474

Centisome position: 26.57

GC content: 70.51

Gene sequence:

>1980_bases
ATGGCGGGCGCGCCGCGCACGTTCACCGCGGTGCTCACGCGCCCCGACGGACAGTCGGCGGCGCTCGCGGCGCAGCTCGC
GGCGGCGGGCATCGACGTGCTCGACTTTCCGCTCATCGACATCGCGCCGCTCGCCGACGACGCGCCGCTCGCCGAAGCGT
TCGCGCGGCTCGACGCGTATGCGCTCGTCGTGTTCGTGTCGCCGAACGCGGTCGATCACGCGCTCGCGCGGCTCGGCGCG
ATCTGGCCGCATCCGCTGCCGATCGGCGTCGTCGGGCCGGGCAGCGTCGCCGCGCTCGCGCGGCACGGCATCGCCGCGCC
CGCGCATCGCGTGATCGCGCCGAGCGCGCCCGACGACGGCGGCGAGCCGCACTACGATTCCGAGAGCCTGTTCGCCGAGA
TCGCGCGTGCGTTCAACGGCGAGGCGAAGCTCGCCGGCAAGCGCGTGCTGATCGTGCGCGGCGACGGCGGCCGCGAATGG
CTTGCCGAGCGCCTGCGCGAGGCGGGCGCCGAAGTCGAGCTCGTCGCCGCGTATCGGCGCGTGAGCCCGGAGCCTTCGAT
CGGCGCGTGGGAGCGCGTGCACGCGCTGCTGTCGGGCGCGCCGCACGCGTGGCTCGTGACGAGCTCGGAGGGCGTGCGCA
ATCTGCAGGAGCTCGCGCACGAGCATTTGAACGAAACGGAGATCGACGCGCTCAAGCACGCCCGGTTCGTCGCGCCGCAT
TCGAGGATCGTCGAGACCGCGCGCGCACTCGGTTTTGATAGGATTACGCTGACCGGCGCGGGCGATGAGCGCATCGTCCG
CGCGTTTCGTACGTTGGCCGATCAGGCCGATCAACCGGCGACAGCCGCACCGATGCCTTCTCGCATGACAGACACCAACG
ATACCAAAGACGTCTCTTCCAAACCGGCCGCGGCTCCCGTTGCGCCGCCGAATCAACCGTTTACGCCGTTTGAAACGAAG
GAGCGGCGCGGCGCGGCGAGCGCGGCGCTCTGGTTCGTGGTCGTCGTGATCGCGGCCGCGGCGGGCGTCGGCGGCTATGC
GCTGAACCGCAAGGTCGACCGCCTCGATCAGCACGCGACCGAGCGGCAAAAGGCGCTCGACGCGCAAACGGCCGAGCTCC
GCACGAAGACCGAACAGGCGCTCGCGAGCGTGCGCCAGGCCGATTCGCAACTGTCGCAGCTCGAAGGCAAGCTCGCCGAC
GCGCAGACCGCGCAGACCGCGCTGCAGCAGCAATATCAGGATCTGTCGCGCAACCGCGACGCGTGGATGATCGAGGAAGT
CGGTCAGATGCTGTCGAGCGCGAGCCAGCAACTGCTGCTCACGGGCAACACGCAGCTCGCGCTGATCGCGCTGCAGAACG
CCGATGCGCGGCTCGCGTCGTCGCAGAGCGCGCAGGCGGTCGTCGTGCGCAAGGCGATCGCGCAGGATATCGAACGGTTG
AAGGCCGCGCCTTCGGCGGATCTCACGGGGCTTGCGATCAAGCTCGACGACGCGATCGCGAAGGTCGACACGCTGCCGCT
CGCGGGCGAAGTGCTCGCGCCGCACGCGCAGGCGAAGCCCGACGCCGCCGCGAGCGCCCGGCAGGCGGCCGCGGCGGCGG
GCGAGCCGCGCTGGAAGGCCTGGTGGCGCGGCTTCTCGGCGGGCATCGGCGAGCAACTGAAGTCGCTCGTCGAGGTGCGC
CGCATCGATCACGCGGACGCGATGCTCGCGTCGCCCGAACAGGGCTACTTCGTGCGCGAGAACGTGAAGCTGCGTCTGCT
GAGCGCGCGGCTGTCGCTGCTCGCGCGCGACGACGGCGCGATGAAGTCCGATCTGCATGCCGCGCAGGCGGCCGTGGCGC
GCTACTTCGACGGCGCATCGAAGGACACCCGGGTCGTTCAGGATCTGCTCAAGCAGGTCGACGCCGCGTCGCTGACGGTC
GCGGTGCCGAACCTCAATACGAGCCTGAACGCGGTTCAACAGTTCAAGAGCCGGGGTTGA

Upstream 100 bases:

>100_bases
TCGGCCGCAGGGTGTCCGACGCGCTCGAGCGGCAAGGCGCGCGCGCGATCGTCGACGCGCTCGTCGCGGCGAGCGCGCAA
GCGCAAAAGGGCGGCGCGTG

Downstream 100 bases:

>100_bases
CGCCATGACGCTGCGTGGAATCATTTGGCTCGCCGTGCTGTTCGCGATCGCCGCGGCGCTCGCGACGGTCGGACGCTTCG
ATACCGGCCAGGTGCTGATC

Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAVDHALARLGA
IWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDSESLFAEIARAFNGEAKLAGKRVLIVRGDGGREW
LAERLREAGAEVELVAAYRRVSPEPSIGAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPH
SRIVETARALGFDRITLTGAGDERIVRAFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKPAAAPVAPPNQPFTPFETK
ERRGAASAALWFVVVVIAAAAGVGGYALNRKVDRLDQHATERQKALDAQTAELRTKTEQALASVRQADSQLSQLEGKLAD
AQTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADARLASSQSAQAVVVRKAIAQDIERL
KAAPSADLTGLAIKLDDAIAKVDTLPLAGEVLAPHAQAKPDAAASARQAAAAAGEPRWKAWWRGFSAGIGEQLKSLVEVR
RIDHADAMLASPEQGYFVRENVKLRLLSARLSLLARDDGAMKSDLHAAQAAVARYFDGASKDTRVVQDLLKQVDAASLTV
AVPNLNTSLNAVQQFKSRG

Sequences:

>Translated_659_residues
MAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAVDHALARLGA
IWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDSESLFAEIARAFNGEAKLAGKRVLIVRGDGGREW
LAERLREAGAEVELVAAYRRVSPEPSIGAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPH
SRIVETARALGFDRITLTGAGDERIVRAFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKPAAAPVAPPNQPFTPFETK
ERRGAASAALWFVVVVIAAAAGVGGYALNRKVDRLDQHATERQKALDAQTAELRTKTEQALASVRQADSQLSQLEGKLAD
AQTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADARLASSQSAQAVVVRKAIAQDIERL
KAAPSADLTGLAIKLDDAIAKVDTLPLAGEVLAPHAQAKPDAAASARQAAAAAGEPRWKAWWRGFSAGIGEQLKSLVEVR
RIDHADAMLASPEQGYFVRENVKLRLLSARLSLLARDDGAMKSDLHAAQAAVARYFDGASKDTRVVQDLLKQVDAASLTV
AVPNLNTSLNAVQQFKSRG
>Mature_658_residues
AGAPRTFTAVLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAVDHALARLGAI
WPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDSESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWL
AERLREAGAEVELVAAYRRVSPEPSIGAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHS
RIVETARALGFDRITLTGAGDERIVRAFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKPAAAPVAPPNQPFTPFETKE
RRGAASAALWFVVVVIAAAAGVGGYALNRKVDRLDQHATERQKALDAQTAELRTKTEQALASVRQADSQLSQLEGKLADA
QTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADARLASSQSAQAVVVRKAIAQDIERLK
AAPSADLTGLAIKLDDAIAKVDTLPLAGEVLAPHAQAKPDAAASARQAAAAAGEPRWKAWWRGFSAGIGEQLKSLVEVRR
IDHADAMLASPEQGYFVRENVKLRLLSARLSLLARDDGAMKSDLHAAQAAVARYFDGASKDTRVVQDLLKQVDAASLTVA
VPNLNTSLNAVQQFKSRG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790235, Length=293, Percent_Identity=24.5733788395904, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790236, Length=277, Percent_Identity=27.7978339350181, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 70052; Mature: 69921

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAY
CCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCHHCCCCCCCCHHHHHHHHHCEE
ALVVFVSPNAVDHALARLGAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDG
EEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCCCCHHEECCCCCCCC
GEPHYDSESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRR
CCCCCCHHHHHHHHHHHHCCCCEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHH
VSPEPSIGAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPH
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
SRIVETARALGFDRITLTGAGDERIVRAFRTLADQADQPATAAPMPSRMTDTNDTKDVSS
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
KPAAAPVAPPNQPFTPFETKERRGAASAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAT
CCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ERQKALDAQTAELRTKTEQALASVRQADSQLSQLEGKLADAQTAQTALQQQYQDLSRNRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADARLASSQSAQAVVVRKAIAQDIERL
CHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHH
KAAPSADLTGLAIKLDDAIAKVDTLPLAGEVLAPHAQAKPDAAASARQAAAAAGEPRWKA
HCCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHH
WWRGFSAGIGEQLKSLVEVRRIDHADAMLASPEQGYFVRENVKLRLLSARLSLLARDDGA
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHCCCCC
MKSDLHAAQAAVARYFDGASKDTRVVQDLLKQVDAASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AGAPRTFTAVLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAY
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCHHCCCCCCCCHHHHHHHHHCEE
ALVVFVSPNAVDHALARLGAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDG
EEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCCCCHHEECCCCCCCC
GEPHYDSESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRR
CCCCCCHHHHHHHHHHHHCCCCEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHH
VSPEPSIGAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPH
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
SRIVETARALGFDRITLTGAGDERIVRAFRTLADQADQPATAAPMPSRMTDTNDTKDVSS
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
KPAAAPVAPPNQPFTPFETKERRGAASAALWFVVVVIAAAAGVGGYALNRKVDRLDQHAT
CCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ERQKALDAQTAELRTKTEQALASVRQADSQLSQLEGKLADAQTAQTALQQQYQDLSRNRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADARLASSQSAQAVVVRKAIAQDIERL
CHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHH
KAAPSADLTGLAIKLDDAIAKVDTLPLAGEVLAPHAQAKPDAAASARQAAAAAGEPRWKA
HCCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHH
WWRGFSAGIGEQLKSLVEVRRIDHADAMLASPEQGYFVRENVKLRLLSARLSLLARDDGA
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHCCCCC
MKSDLHAAQAAVARYFDGASKDTRVVQDLLKQVDAASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]