Click here to switch to the map view.

The map label for this gene is hemC

Identifier: 126455102

GI number: 126455102

Start: 1058658

End: 1059647

Strand: Direct

Name: hemC

Synonym: BURPS1106A_1077

Alternate gene names: 126455102

Gene position: 1058658-1059647 (Clockwise)

Preceding gene: 126454870

Following gene: 126453804

Centisome position: 26.54

GC content: 73.03

Gene sequence:

>990_bases
ATGAACTCCGAGACTCTTCCGGCCGAGCTGCCCGCGACGCTGACGATCGCGTCGCGCGAGAGCCGCCTCGCCATGTGGCA
AGCCGAGCATGTGCGTGATGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAAAATCCTCGGGATGACGACGCGCGGCG
ATCAAATTCTCGATCGCACGCTATCGAAGGTCGGCGGCAAGGGCCTGTTCGTCAAGGAGCTCGAGAGCGCGCTCGCCGAC
GGCCGCGCGGATCTCGCCGTGCATTCGCTGAAGGACGTGCCGATGGCGCTGCCCGAAGGCTTCGCGCTCGCGGCGGTGAT
GAGCCGCGAGGATCCGCGCGACGCGTTCGTGTCGAACGATTACGCGTCGCTCGACGCGCTGCCGGCGGGCGCCGTCGTCG
GCACGTCGAGCCTGCGCCGCGAGGCGATGCTGCGCGCGCGCCATCCGCGGCTCGACGTGCGGCCGCTGCGCGGCAATCTC
GACACGCGGCTCGCGAAGCTCGACCGCGGCGATTACGCGGCGATCATCCTCGCCGCCGCGGGCCTCAAGCGTCTCGGCCT
CGCCGCGCGGATCCGCGCGCTGCTCGACGTCGACGACAGCCTGCCCGCCGCGGGGCAGGGCGCGCTCGGCATCGAGATCG
CCGCGCGCCGCGCCGATGTCGCCGCGTGGCTCGCGCCGCTGCATGATCATGCGAGCGCGCTCGCGGTCGAGGCCGAACGC
GCGGTGTCGCGCGCGCTCGGCGGCAGTTGCGAGGTGCCGCTCGCCGCGCACGCGGTGTGGCGCGGCGGCGAGCTGCATCT
GACGGGCAGCGTGTCGACGACGGACGGCGCGCGCGTGCTCGCCGCGCATGCGCACGCACGCGCGGCGACGGCCGCCGATG
CGCTCGCGCTCGGCCGCAGGGTGTCCGACGCGCTCGAGCGGCAAGGCGCGCGCGCGATCGTCGACGCGCTCGTCGCGGCG
AGCGCGCAAGCGCAAAAGGGCGGCGCGTGA

Upstream 100 bases:

>100_bases
GACCGGACGGGCCGTTCGCGCAGCCCGCCCGGCGGGCGGGCGGGCAAGGTGCGCGTGCTACCATAGTCCGTTCCCAATCC
CGCCTTTCGATGTCCCTGCA

Downstream 100 bases:

>100_bases
TGGCGGGCGCGCCGCGCACGTTCACCGCGGTGCTCACGCGCCCCGACGGACAGTCGGCGGCGCTCGCGGCGCAGCTCGCG
GCGGCGGGCATCGACGTGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAER
AVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARAIVDALVAA
SAQAQKGGA

Sequences:

>Translated_329_residues
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAER
AVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARAIVDALVAA
SAQAQKGGA
>Mature_329_residues
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAER
AVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARAIVDALVAA
SAQAQKGGA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=266, Percent_Identity=46.2406015037594, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI66933009, Length=266, Percent_Identity=46.2406015037594, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI48994974, Length=315, Percent_Identity=51.4285714285714, Blast_Score=295, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=38.5579937304075, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=44.0140845070423, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_BURM7 (A3MLK5)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001081141.1
- ProteinModelPortal:   A3MLK5
- SMR:   A3MLK5
- GeneID:   4892665
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_1597
- TIGR:   BMA10247_1597
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   BMAL320389:BMA10247_1597-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 34410; Mature: 34410

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRT
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LSKVGGKGLFVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSND
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCC
YASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAA
CHHHCCCCCCHHHCHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHH
GLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAER
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRR
HHHHHCCCCCCCCHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSDALERQGARAIVDALVAASAQAQKGGA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRT
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LSKVGGKGLFVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSND
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCC
YASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAA
CHHHCCCCCCHHHCHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHH
GLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAER
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRR
HHHHHCCCCCCCCHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSDALERQGARAIVDALVAASAQAQKGGA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA