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The map label for this gene is gyrA [H]

Identifier: 126453773

GI number: 126453773

Start: 2894924

End: 2897524

Strand: Reverse

Name: gyrA [H]

Synonym: BURPS1106A_2951

Alternate gene names: 126453773

Gene position: 2897524-2894924 (Counterclockwise)

Preceding gene: 126453335

Following gene: 126453782

Centisome position: 72.65

GC content: 65.21

Gene sequence:

>2601_bases
ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTCGAGGAGGAAATGCGCAAGTCGTATCTCGATTACGCCATGAG
CGTGATCGTCGGCCGTGCCCTTCCGGATGTCCGCGATGGCTTGAAGCCCGTGCACCGGCGCGTGCTGTTCGCGATGCACG
AGCTGAACAACGACTGGAACCGGCCGTACAAGAAGTCCGCGCGTATCGTCGGCGACGTGATCGGTAAGTACCATCCGCAC
GGCGACACCGCGGTCTACGACACGATCGTCCGGATGGCTCAGGATTTCTCGCTGCGTTACATGCTCGTCGACGGCCAGGG
CAACTTCGGCTCGGTCGACGGCGATAACGCGGCCGCGATGCGCTACACCGAAATCCGGATGGCCAAGATCGGCCACGAAC
TGCTCGCGGACATCGACAAGGAAACCGTCGACTTCGGCCCGAACTACGACGGCAGCGAGATGCAGCCGCTCATCCTGCCG
TCGCGGATTCCGAACCTCCTCATCAACGGTTCGTCGGGGATCGCGGTCGGCATGGCGACCAACATCCCGCCGCACAACCT
GAACGAGGTCGTCGACGCCTGCCTTTACCTGCTGAACAATCCGCAGGCGAGCGTCGACGAACTGATCGAGATCATCCCCG
CGCCCGATTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTATCGCACCGGGCGCGGGCGCGTC
GTGATGCGCGCGGCCACGCACTTCGAGGAGATCGACCGCGGCCAGCGCATGGCGATCATCGTCGACGAACTGCCGTACCA
GGTCAACAAGCGCTCGCTGCTCGAGCGGATCGCGGAGCTCGTCAACGAGAAGAAGCTCGAGGGCATCTCCGACATCCGCG
ACGAATCCGACAAGAGCGGCATGCGCGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCCGAGGTGGTGCTGAACAACCTG
TACAAGGCGACTCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACAACCAGCCGAAGCTCCTGAATCT
GCGGGAGATCCTGCAGTGCTTCCTGTCGCATCGGCGCGAAGTGCTGACGCGGCGCACCGTCTACGAACTGCGCAAGGCGC
GCGAGCGCGGCCACGTGCTCGAAGGCCTCGCCGTCGCGCTCGCGAACATCGACGAGTTCATCGCGATCATCAAAGCCGCG
CCGACGCCGCCGATCGCGAAGCAGGAGCTGATGGCGAAATCGTGGGATTCGTCGCTCGTGCGCGACATGCTCACGCGCGC
GGAAACCGAGAACGCGGCGGCCGGCGGGCGCGACGCGTACCGTCCGGAAGGCCTGAGTCCGGCGTTCGGCATGCAGGGCG
ACGGCCTGTACCGGCTGTCCGACACGCAGGCGCAGGAAATCCTCCAGATGCGCCTGCAGCGCCTCACGGGCCTCGAGCAG
GACAAGATCATCGGCGAATATCGCGACGTGATGGCGCAGATCGCCGATCTGCTCGACATTCTCGCGCGGCCCGAGCGGAT
CACGACGCTGATCGGCGACGAACTGACGCAGGTGAAGGCGGAGTTCGGCGATGCGCGCCGCTCGAAGATCGAGCTGAACG
CGACCGAGCTGAACACCGAAGACCTGATCACGCCGCAGGACATGGTGGTCACGATGTCGCACGCGGGCTACGTGAAGTCG
CAGCCGCTGTCCGAGTACCGCGCGCAAAAGCGCGGCGGCCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGAT
CGAGACGCTGTTCATCGCGAACACGCACGACTACATCCTATGCTTCTCGAACCGCGGCCGCGTGTACTGGGTCAAGGTGT
ACGAGGTGCCGCAGGGCTCGCGCAACTCGCGCGGCCGTCCGATCGTCAACATGTTCCCGCTGCAGGACGGCGAGAAGATC
AATGTCGTGCTGCCCGTGAAGGAATTCTCGGCCGACAAGTACGTGTTCATGACGACGGCTTTGGGCACGGTCAAGAAGAC
GCCGCTCGAAGCGTTCAGCCGCCCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGACGGCGATTACCTGATCGGCG
CGGCGATCACCGACGGCGCGCACGACGTGATGCTGTTCTCCGACGCCGGCAAGGCGGTGCGTTTCGACGAGAACGACGTG
CGGCCGATGGGCCGCGAGGCGCGCGGCGTGCGCGGGATGCAGCTCGACGACGCCCAGCAGGTGATCGCGATGCTCGTCGC
GGGCAGCGAGGAACAGTCGGTGCTGACCGCGACCGAGAACGGCTACGGCAAGCGCACGCCGATCACCGAGTACACGCGCC
ACGGGCGCGGCACGAAGGGGATGATCGCGATCCAGACCTCCGAGCGCAACGGCCGCGTCGTTGCCGCGACGCTCGTCGAC
CCCGAGGATCAGATCATGCTGATCACGACGGCGGGCGTGCTGATCCGCACGCGCGTGTCGGAGATTCGCGAGATGGGGCG
GGCGACGCAAGGTGTTACACTCATCAGTCTCGATGAAGGCACCAAGCTTTCGGGTCTGCAGCAGATCGCCGAGGCGGACG
CCGATGCCGACGACGATGCGGTGGAGGGCGGCGACGCCTGA

Upstream 100 bases:

>100_bases
TGGGGCGGGTTGGGGCGCATGTTAGAATCGCACGTTGCGTCGCGCGAGCGGCGCCCACGCGAAAGGCGGCCCCGTCTTCG
CTCCGAAAAGATACGGATAC

Downstream 100 bases:

>100_bases
GTCAGGTTGTGACCGTCGAGCCGGCGCCCGGCGCGCGCGCAAAGAGGTGGCGTGACGGGCGCGGCGTATAAACTGTACAT
ATTTCCATGAGGGAGTGATG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 866; Mature: 866

Protein sequence:

>866_residues
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKSWDSSLVRDMLTRAETENAAAGGRDAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQIADLLDILARPERITTLIGDELTQVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDDAQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVD
PEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDAVEGGDA

Sequences:

>Translated_866_residues
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKSWDSSLVRDMLTRAETENAAAGGRDAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQIADLLDILARPERITTLIGDELTQVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDDAQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVD
PEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDAVEGGDA
>Mature_866_residues
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKSWDSSLVRDMLTRAETENAAAGGRDAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQIADLLDILARPERITTLIGDELTQVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDDAQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVD
PEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDAVEGGDA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=378, Percent_Identity=25.6613756613757, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=25.5451713395639, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1788562, Length=866, Percent_Identity=59.5842956120092, Blast_Score=1044, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=737, Percent_Identity=34.3283582089552, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=380, Percent_Identity=26.0526315789474, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=409, Percent_Identity=25.4278728606357, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=187, Percent_Identity=30.4812834224599, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=25.9365994236311, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.9340974212034, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96160; Mature: 96160

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPSRIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKSWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
RDMLTRAETENAAAGGRDAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYRDVMAQIADLLDILARPERITTLIGDELTQVKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL
HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKYVFMTTA
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEH
LGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
HHHHHCCHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC
RPMGREARGVRGMQLDDAQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKG
CCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCC
MIAIQTSERNGRVVAATLVDPEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQIAEADADADDDAVEGGDA
CCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPSRIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKSWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
RDMLTRAETENAAAGGRDAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYRDVMAQIADLLDILARPERITTLIGDELTQVKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL
HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKYVFMTTA
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEH
LGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
HHHHHCCHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC
RPMGREARGVRGMQLDDAQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKG
CCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCC
MIAIQTSERNGRVVAATLVDPEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQIAEADADADDDAVEGGDA
CCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]