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The map label for this gene is adh [H]

Identifier: 126453705

GI number: 126453705

Start: 1268244

End: 1269326

Strand: Direct

Name: adh [H]

Synonym: BURPS1106A_1295

Alternate gene names: 126453705

Gene position: 1268244-1269326 (Clockwise)

Preceding gene: 126454918

Following gene: 126452700

Centisome position: 31.8

GC content: 69.53

Gene sequence:

>1083_bases
ATGGGCCGGTTTGCGTGGCGCGCGTCGCGCGCGCAAACCCGTCACGATCTTGGAGCGACGTGCATGAAAGCGATCGAAAT
CACCGAATTCGGCGCGCCCGACGTGCTGAAGCTGACGGAGCGGCCGCAGCCCGAACCGAAGCGCGGCGAGGTGCTGATCA
AGGTGGCGGCGTCGGGCGTCAACCGTCCGGACGTGTTCCAGAGAAAGGGGGCCTACGCGCCGCCGCCCGGCGCGTCGGAT
CTGCCGGGGCTCGAGGTGGCGGGCGAGATCGTCGGCGGCGACCTCGCCGATTCCGCGGCGAACCCGTTCGGGCTGAAGCT
CTGCGACCGCGTTTGCGCGCTGCTCGCGGGCGGCGGTTATGCGCAATACGTCGCGGCGCCGCTCGCGCAGTGCCTGCCGG
TGCCGAAGGGGTTGACCGATGTGGACGCGGCGTCGTTGCCCGAGACGTTCTTCACGGTCTGGAGCAACGTGTTCGATCGC
GCACAATTGGGCGCGGGCGAGGGCGGCGCGCAGGAAACGTTCCTCGTGCAAGGGGGCTCGAGCGGCATCGGCGTGACGGC
GATCCAGATCGCGCATGCGCTCGGCTTTCGCGTGTTCGCGACCGCGGGCACCGATGACAAGTGCCGCGCGTGCGAGGCGC
TCGGCGCGGAGCGCGCGATCAACTACAAGTCCGAGGATTTCGTCGAGGTCGTGAAGTCGCTCACGCACGATCGCGGCGTC
GACGTGATTCTCGACATGGTCGCGGGCGCGTACGTGCCGCGCGAGCTGGCGGCGCTCGCCGACGGTGGGCGGCTCGTCGT
GATCGCGCTGCTCGGCGGTGCGAAGGCGGAAATCAACGTGGCCGAGATCCTGCGGCGTCGCCTCACGATCACGGGCTCGA
CGCTGCGGCCGCGCCCCGTCGAATTCAAGGCGGCCATCGCCGCGCAACTGAAGGCGCGCGTGTGGCCGCTTATCGAGGAC
GGGCGCGTGAAGCCCGTCATCTATCGCGTGCTGCCGGCCGCGCAGGCCGCCGACGCGCATGCGCTGATGGAGAGCAGCGA
GCACGTCGGCAAGATCGTGCTCGATTGGGGTGCGAACGCTTGA

Upstream 100 bases:

>100_bases
CTGCTGAACGAGGCGGCCGCCCAGGCGGATACGCCGCCGCAGCAGTAAGCGGCAAGGCGACGGCCGGCAGCGCGAATGCG
CGCCGGCCGTTTTTCACAGG

Downstream 100 bases:

>100_bases
CATCGGTCGTTTGACCGGTTCTTCAGCGTCGCAGTAAAATCGCGGGTTCGCTTCGCCAGATGAACACGACGCCCGGCTTC
GGCGCGTCCACGACGAGACA

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MGRFAWRASRAQTRHDLGATCMKAIEITEFGAPDVLKLTERPQPEPKRGEVLIKVAASGVNRPDVFQRKGAYAPPPGASD
LPGLEVAGEIVGGDLADSAANPFGLKLCDRVCALLAGGGYAQYVAAPLAQCLPVPKGLTDVDAASLPETFFTVWSNVFDR
AQLGAGEGGAQETFLVQGGSSGIGVTAIQIAHALGFRVFATAGTDDKCRACEALGAERAINYKSEDFVEVVKSLTHDRGV
DVILDMVAGAYVPRELAALADGGRLVVIALLGGAKAEINVAEILRRRLTITGSTLRPRPVEFKAAIAAQLKARVWPLIED
GRVKPVIYRVLPAAQAADAHALMESSEHVGKIVLDWGANA

Sequences:

>Translated_360_residues
MGRFAWRASRAQTRHDLGATCMKAIEITEFGAPDVLKLTERPQPEPKRGEVLIKVAASGVNRPDVFQRKGAYAPPPGASD
LPGLEVAGEIVGGDLADSAANPFGLKLCDRVCALLAGGGYAQYVAAPLAQCLPVPKGLTDVDAASLPETFFTVWSNVFDR
AQLGAGEGGAQETFLVQGGSSGIGVTAIQIAHALGFRVFATAGTDDKCRACEALGAERAINYKSEDFVEVVKSLTHDRGV
DVILDMVAGAYVPRELAALADGGRLVVIALLGGAKAEINVAEILRRRLTITGSTLRPRPVEFKAAIAAQLKARVWPLIED
GRVKPVIYRVLPAAQAADAHALMESSEHVGKIVLDWGANA
>Mature_359_residues
GRFAWRASRAQTRHDLGATCMKAIEITEFGAPDVLKLTERPQPEPKRGEVLIKVAASGVNRPDVFQRKGAYAPPPGASDL
PGLEVAGEIVGGDLADSAANPFGLKLCDRVCALLAGGGYAQYVAAPLAQCLPVPKGLTDVDAASLPETFFTVWSNVFDRA
QLGAGEGGAQETFLVQGGSSGIGVTAIQIAHALGFRVFATAGTDDKCRACEALGAERAINYKSEDFVEVVKSLTHDRGVD
VILDMVAGAYVPRELAALADGGRLVVIALLGGAKAEINVAEILRRRLTITGSTLRPRPVEFKAAIAAQLKARVWPLIEDG
RVKPVIYRVLPAAQAADAHALMESSEHVGKIVLDWGANA

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=340, Percent_Identity=36.4705882352941, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI22538444, Length=340, Percent_Identity=36.4705882352941, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI194239674, Length=341, Percent_Identity=33.1378299120235, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI13236495, Length=341, Percent_Identity=33.1378299120235, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI194239676, Length=341, Percent_Identity=30.2052785923754, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI18379349, Length=352, Percent_Identity=26.9886363636364, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24308257, Length=363, Percent_Identity=26.1707988980716, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI197927207, Length=186, Percent_Identity=32.258064516129, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI28557745, Length=289, Percent_Identity=29.757785467128, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI41872631, Length=320, Percent_Identity=27.5, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI47519420, Length=360, Percent_Identity=25.8333333333333, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790485, Length=343, Percent_Identity=28.8629737609329, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=347, Percent_Identity=28.2420749279539, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319520, Length=342, Percent_Identity=26.0233918128655, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=294, Percent_Identity=26.8707482993197, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=351, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24581345, Length=249, Percent_Identity=24.8995983935743, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=24.6428571428571, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=24.6428571428571, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37912; Mature: 37781

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRFAWRASRAQTRHDLGATCMKAIEITEFGAPDVLKLTERPQPEPKRGEVLIKVAASGV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCEEEEEECCCC
NRPDVFQRKGAYAPPPGASDLPGLEVAGEIVGGDLADSAANPFGLKLCDRVCALLAGGGY
CCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHCCCH
AQYVAAPLAQCLPVPKGLTDVDAASLPETFFTVWSNVFDRAQLGAGEGGAQETFLVQGGS
HHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
SGIGVTAIQIAHALGFRVFATAGTDDKCRACEALGAERAINYKSEDFVEVVKSLTHDRGV
CCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHCCCCH
DVILDMVAGAYVPRELAALADGGRLVVIALLGGAKAEINVAEILRRRLTITGSTLRPRPV
HHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCC
EFKAAIAAQLKARVWPLIEDGRVKPVIYRVLPAAQAADAHALMESSEHVGKIVLDWGANA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCC
>Mature Secondary Structure 
GRFAWRASRAQTRHDLGATCMKAIEITEFGAPDVLKLTERPQPEPKRGEVLIKVAASGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCEEEEEECCCC
NRPDVFQRKGAYAPPPGASDLPGLEVAGEIVGGDLADSAANPFGLKLCDRVCALLAGGGY
CCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHCCCH
AQYVAAPLAQCLPVPKGLTDVDAASLPETFFTVWSNVFDRAQLGAGEGGAQETFLVQGGS
HHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
SGIGVTAIQIAHALGFRVFATAGTDDKCRACEALGAERAINYKSEDFVEVVKSLTHDRGV
CCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHCCCCH
DVILDMVAGAYVPRELAALADGGRLVVIALLGGAKAEINVAEILRRRLTITGSTLRPRPV
HHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCC
EFKAAIAAQLKARVWPLIEDGRVKPVIYRVLPAAQAADAHALMESSEHVGKIVLDWGANA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]