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The map label for this gene is lon2 [H]

Identifier: 126453536

GI number: 126453536

Start: 233707

End: 234687

Strand: Direct

Name: lon2 [H]

Synonym: BURPS1106A_0250

Alternate gene names: 126453536

Gene position: 233707-234687 (Clockwise)

Preceding gene: 126452164

Following gene: 126454680

Centisome position: 5.86

GC content: 67.28

Gene sequence:

>981_bases
ATGACGACGGCGATGGTGAAACAGGAACTGGCGGTGGCTTCGTTCAGCACGGTCTACGATATCGAGCGAATCGAGACGGC
GCTGAACGATCTGAACGAAGGCGCGAGCGATGCATTGCGCGCGACCTACGAGAAGATGCTGAAGACGGGCAATCTGCGCT
TTTGCGTGAAGCCGACGCGCATGCCCGCGTTCGATTCGCTTGCGCAGGCGTTGCCGAACTTCGCCGAGCCGCTCGACGAC
GTGCGCAAGCAGGTGGCGCTGTGCCTCGAGACCGACGATCGCCTCGAATTGATGCCGATCCTGCTGCTCGGCGAGCCGGG
CATCGGCAAGACGCATTTCGCGAAGGCGCTCGCGAAGATGCTCGGGACCGCTTACCACTACGTGCCGATGAGCTCGCTCA
CGGCGGGCTGGGTGCTCTCGGGCGCGTCGTCGCAGTGGAAGAACGCGAAGCCGGGCAAGGTGTTCGACGCGCTCGTCAAC
GGCTGCTATTCGAACCCGGTGATCGCGATCGACGAGATCGACAAGGCGGGCAGCGACGCGCAGTACGATCCGCTCGGCGC
GCTGTATGCGCTTCTCGAGCACGACACCGCGAGCGCGTTCGTCGACGAATTCGCCGAGGTGCCGATCGACGCGGGCAACG
TGATCTGGATCGCGACCGCGAACGACGCGAGCGCGATTCCCGAGCCGATCATGAACCGGATGAACGTGTACGAGATCGAG
CCGCCCGATGCGTCGGGCGCGCGCCGCATCGCGCAGACGATCTACGGCGAGATCCGCAACGCGCACGCGTGGGGGCAGCG
CTTTCCCGCCGCGCTCGGCGACGACGCGCTCGACGTGCTCGCCGCGATGCCGCCGCGCACGATGCGCCGCGTGCTGCTGC
ATGCGTTCGGCGCGGCGCGGCTCGACGGGCGGGACGCGGTCGCGCCGCGCGACATCCGCACCGACGAGAGCGCGGGGCGG
CGCCGTCCGATCGGCTTTTGA

Upstream 100 bases:

>100_bases
CAGCAGACCCCGGCGGCTGCTTGCTTGCACGCGATTTCGGGCTCGCTACACTGAAGTCGACGGGGTCTGATGGGTGGGCG
GTAGCAAGGCGAGGTGTGCG

Downstream 100 bases:

>100_bases
CGGGCGGCGCGCGCGTGCGCTTCGCGCGACGTACAATCGAAGGTCCTGCCTTCGAAGCGTGAGCGAAGCGAATGACGATC
GAGCGGATTGACTGTGTGGT

Product: ATP-dependent protease domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTTAMVKQELAVASFSTVYDIERIETALNDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAQALPNFAEPLDD
VRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVN
GCYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
PPDASGARRIAQTIYGEIRNAHAWGQRFPAALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAVAPRDIRTDESAGR
RRPIGF

Sequences:

>Translated_326_residues
MTTAMVKQELAVASFSTVYDIERIETALNDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAQALPNFAEPLDD
VRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVN
GCYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
PPDASGARRIAQTIYGEIRNAHAWGQRFPAALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAVAPRDIRTDESAGR
RRPIGF
>Mature_325_residues
TTAMVKQELAVASFSTVYDIERIETALNDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAQALPNFAEPLDDV
RKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNG
CYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIEP
PDASGARRIAQTIYGEIRNAHAWGQRFPAALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAVAPRDIRTDESAGRR
RPIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=140, Percent_Identity=35, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI31377667, Length=142, Percent_Identity=32.3943661971831, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786643, Length=142, Percent_Identity=33.8028169014084, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17556486, Length=168, Percent_Identity=32.1428571428571, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17505831, Length=137, Percent_Identity=35.036496350365, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319449, Length=154, Percent_Identity=33.7662337662338, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24666867, Length=136, Percent_Identity=36.7647058823529, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221513036, Length=136, Percent_Identity=36.7647058823529, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35451; Mature: 35320

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMVKQELAVASFSTVYDIERIETALNDLNEGASDALRATYEKMLKTGNLRFCVKPTR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCC
MPAFDSLAQALPNFAEPLDDVRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKM
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGCYSNPVIAIDEIDKAGSDA
HHHHHHHCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEC
PPDASGARRIAQTIYGEIRNAHAWGQRFPAALGDDALDVLAAMPPRTMRRVLLHAFGAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
LDGRDAVAPRDIRTDESAGRRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTAMVKQELAVASFSTVYDIERIETALNDLNEGASDALRATYEKMLKTGNLRFCVKPTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCC
MPAFDSLAQALPNFAEPLDDVRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKM
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGCYSNPVIAIDEIDKAGSDA
HHHHHHHCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEC
PPDASGARRIAQTIYGEIRNAHAWGQRFPAALGDDALDVLAAMPPRTMRRVLLHAFGAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
LDGRDAVAPRDIRTDESAGRRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA