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The map label for this gene is lhgO [H]

Identifier: 126454680

GI number: 126454680

Start: 234759

End: 235880

Strand: Direct

Name: lhgO [H]

Synonym: BURPS1106A_0251

Alternate gene names: 126454680

Gene position: 234759-235880 (Clockwise)

Preceding gene: 126453536

Following gene: 126452268

Centisome position: 5.89

GC content: 71.03

Gene sequence:

>1122_bases
ATGACGATCGAGCGGATTGACTGTGTGGTGATCGGCGCCGGCGTTGTCGGCCTGGCGATCGCGCGCGAGCTGGCCGCGCG
CGGACGCGAGACGCTGATCCTGGAGGCGGCCGACGCGATCGGCACGGGCATGAGTTCGCGCAACAGCGAGGTGATCCATG
CGGGGCTCTACTACCCGCGCGGGTCGCTGAAGGCTTCGCTGTGCTTGCACGGGCGAGACCTGCTGTACGACTTTTGCGAG
ACGCACGGCGTGCCGCACCGGCGCTGCGGCAAGCTCGTCGTCGCGACCTCGCCCGCGCAGGCGAAGCAGTTGAAGGCGAT
CGCCGCGCGCGCGGAGGAAAACGGCGTGCTCGATTTGCTGACGCTGTCGCGCGACGAGGTGCAGGCGCTCGAGCCCGAGC
TCGAATGCCTCGAGGCGCTGTTCTCGCCGAGCACGGGCATCATCGACAGCCATCAGCTGATGCTCGCGCTGCTCGGCGAC
GCCGAGCGCGACGGCGCATCGTGCGCGCTGCGCTCGCCCGTCGAATCGATCGACGCGGCGGGCGGCCGCTTCGTCGTGCG
CACGGGCGGCGAAGCGCCGGCCGCGATCGCGGCCGCATGCGTGATCAACAGCGCGGGGCTCGACGCGCAGGCGCTCGCCA
AGCGCATCCGCGGGCTCGATTCGCGCTGGGTGCCGCCGCTCTATCTCGCGCGCGGCAATTACTTCAGCCTGTCCGGCCGC
GCGCCGTTCGCGCATCTCGTCTATCCGGTGCCGGACCGCGCCGGGCTGGGCGTGCACCTGACGCTCGATCTCGCCGGCGA
CGCCCGCTTCGGGCCCGACGTCGAATGGATCGACGCGCTGCGTTACGACGTCGACCCGCGCCGTGCCGAATCTTTCTGCA
CGTCGATCCGCGCGTATTGGCCGGGATTGCCCGAAGGCTCGCTGCGGCCGGCTTACGCGGGCATTCGTGCGAAAGTCTCC
GGTCCCGGCGAGCCTGCCGCCGATTTCGTGATCCAGGGCACGGCGCAGCACGGCGTGCGCGGGCTCGTGAACCTGTTCGG
CATCGAGTCGCCCGGGCTCACCGCGGCGCTCGCGATCGCGCAGCGCGTCGGCGACATGGCGGCGCGCACGCGGCATACGT
AG

Upstream 100 bases:

>100_bases
CGGGGCGGCGCCGTCCGATCGGCTTTTGACGGGCGGCGCGCGCGTGCGCTTCGCGCGACGTACAATCGAAGGTCCTGCCT
TCGAAGCGTGAGCGAAGCGA

Downstream 100 bases:

>100_bases
CGTGTGTGACGATTTCTTGTTTTCGGTTGGCTTATCTTCGGAATTACTCGCGACACATCGGGGCGCATGAGCGGTATGCT
TGTGCGCTGCTGCCGCTAGA

Product: FAD-dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTIERIDCVVIGAGVVGLAIARELAARGRETLILEAADAIGTGMSSRNSEVIHAGLYYPRGSLKASLCLHGRDLLYDFCE
THGVPHRRCGKLVVATSPAQAKQLKAIAARAEENGVLDLLTLSRDEVQALEPELECLEALFSPSTGIIDSHQLMLALLGD
AERDGASCALRSPVESIDAAGGRFVVRTGGEAPAAIAAACVINSAGLDAQALAKRIRGLDSRWVPPLYLARGNYFSLSGR
APFAHLVYPVPDRAGLGVHLTLDLAGDARFGPDVEWIDALRYDVDPRRAESFCTSIRAYWPGLPEGSLRPAYAGIRAKVS
GPGEPAADFVIQGTAQHGVRGLVNLFGIESPGLTAALAIAQRVGDMAARTRHT

Sequences:

>Translated_373_residues
MTIERIDCVVIGAGVVGLAIARELAARGRETLILEAADAIGTGMSSRNSEVIHAGLYYPRGSLKASLCLHGRDLLYDFCE
THGVPHRRCGKLVVATSPAQAKQLKAIAARAEENGVLDLLTLSRDEVQALEPELECLEALFSPSTGIIDSHQLMLALLGD
AERDGASCALRSPVESIDAAGGRFVVRTGGEAPAAIAAACVINSAGLDAQALAKRIRGLDSRWVPPLYLARGNYFSLSGR
APFAHLVYPVPDRAGLGVHLTLDLAGDARFGPDVEWIDALRYDVDPRRAESFCTSIRAYWPGLPEGSLRPAYAGIRAKVS
GPGEPAADFVIQGTAQHGVRGLVNLFGIESPGLTAALAIAQRVGDMAARTRHT
>Mature_372_residues
TIERIDCVVIGAGVVGLAIARELAARGRETLILEAADAIGTGMSSRNSEVIHAGLYYPRGSLKASLCLHGRDLLYDFCET
HGVPHRRCGKLVVATSPAQAKQLKAIAARAEENGVLDLLTLSRDEVQALEPELECLEALFSPSTGIIDSHQLMLALLGDA
ERDGASCALRSPVESIDAAGGRFVVRTGGEAPAAIAAACVINSAGLDAQALAKRIRGLDSRWVPPLYLARGNYFSLSGRA
PFAHLVYPVPDRAGLGVHLTLDLAGDARFGPDVEWIDALRYDVDPRRAESFCTSIRAYWPGLPEGSLRPAYAGIRAKVSG
PGEPAADFVIQGTAQHGVRGLVNLFGIESPGLTAALAIAQRVGDMAARTRHT

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=259, Percent_Identity=32.8185328185328, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI87082148, Length=372, Percent_Identity=29.8387096774194, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17565764, Length=406, Percent_Identity=30.2955665024631, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24585081, Length=397, Percent_Identity=29.9748110831234, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39475; Mature: 39343

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIERIDCVVIGAGVVGLAIARELAARGRETLILEAADAIGTGMSSRNSEVIHAGLYYPR
CCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCEEEEEEECCC
GSLKASLCLHGRDLLYDFCETHGVPHRRCGKLVVATSPAQAKQLKAIAARAEENGVLDLL
CCCEEEEEECCHHHHHHHHHHCCCCCHHHCCEEEEECCHHHHHHHHHHHHHCCCCCEEEE
TLSRDEVQALEPELECLEALFSPSTGIIDSHQLMLALLGDAERDGASCALRSPVESIDAA
ECCHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEHHCCHHHHHCC
GGRFVVRTGGEAPAAIAAACVINSAGLDAQALAKRIRGLDSRWVPPLYLARGNYFSLSGR
CCEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEEECCC
APFAHLVYPVPDRAGLGVHLTLDLAGDARFGPDVEWIDALRYDVDPRRAESFCTSIRAYW
CCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHC
PGLPEGSLRPAYAGIRAKVSGPGEPAADFVIQGTAQHGVRGLVNLFGIESPGLTAALAIA
CCCCCCCCCCHHHCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHH
QRVGDMAARTRHT
HHHHHHHHHCCCC
>Mature Secondary Structure 
TIERIDCVVIGAGVVGLAIARELAARGRETLILEAADAIGTGMSSRNSEVIHAGLYYPR
CCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCEEEEEEECCC
GSLKASLCLHGRDLLYDFCETHGVPHRRCGKLVVATSPAQAKQLKAIAARAEENGVLDLL
CCCEEEEEECCHHHHHHHHHHCCCCCHHHCCEEEEECCHHHHHHHHHHHHHCCCCCEEEE
TLSRDEVQALEPELECLEALFSPSTGIIDSHQLMLALLGDAERDGASCALRSPVESIDAA
ECCHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEHHCCHHHHHCC
GGRFVVRTGGEAPAAIAAACVINSAGLDAQALAKRIRGLDSRWVPPLYLARGNYFSLSGR
CCEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEEECCC
APFAHLVYPVPDRAGLGVHLTLDLAGDARFGPDVEWIDALRYDVDPRRAESFCTSIRAYW
CCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHC
PGLPEGSLRPAYAGIRAKVSGPGEPAADFVIQGTAQHGVRGLVNLFGIESPGLTAALAIA
CCCCCCCCCCHHHCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHH
QRVGDMAARTRHT
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]