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The map label for this gene is pyrD [H]

Identifier: 126453525

GI number: 126453525

Start: 1788046

End: 1789074

Strand: Reverse

Name: pyrD [H]

Synonym: BURPS1106A_1825

Alternate gene names: 126453525

Gene position: 1789074-1788046 (Counterclockwise)

Preceding gene: 126452638

Following gene: 126455413

Centisome position: 44.86

GC content: 70.17

Gene sequence:

>1029_bases
GTGTTCAGCTCCCTCTACCCGCTTGCCCGCGCGTCCCTCTTCAAGATGGATGCGGAGGACGCCCATCATCTGACCCTGCG
CATGCTCGGCGCCGCGGGCCGCACGGGCCTCGCGTGCGCGCTGTCGCCCCGCGTGCCCGACGCGCCGCGCACCGTGATGG
GGCTCTCGTTCCGCAATCCGGTCGGGCTCGCGGCCGGCCTCGACAAGGACGGCGCGGCGATCGACGGCTTCGCCGCGCTC
GGCTTCGGCTTCATCGAGGTGGGCACCGTCACGCCGCGCGCGCAGCCCGGCAACCCGCGCCCGCGGATGTTCCGGCTACC
CGAGGCGGACGCGATCATCAACCGGATGGGCTTCAACAACAGCGGCGTCGACCAGTTCGTGAAGAACGTGCAGGCGGCGC
GCTATCGCGGCGTGCTCGGCCTGAACATCGGCAAGAACGCCGACACGCCGATCGAGCGCGCGGCCGACGATTACCTGTAC
TGCCTCGAGCGCGTCTACCCGTTCGCGAGCTACGTGACGATCAACATCTCGTCGCCGAACACGAAGAACCTGCGCCAGCT
CCAGGGCGCGGGCGAGCTCGACGCGCTGCTCGCCGCGCTGAAGGACAAGCAGCGGCGCCTCGCCGACCTGCACGGCAAGC
TCGTGCCGCTCGCGCTGAAGATCGCGCCCGATCTCGACGACGAACAGGTGAAGGAAATCGCCGCAACGCTGCTGCGCCAC
GACATCGAAGGCGTGATCGCGACCAACACCACGCTGTCGCGCGAAGCGGTGAAAGGCCTGCCGCACGCCGACGAGGCGGG
CGGACTGTCCGGGCGGCCGGTGTTCGACGCGTCGAACGCGGTGATCCGCAAGCTGCGCGCGGAGCTTGGCGACGCGGTGC
CGATCATCGGCGTGGGCGGCATCTTCTCCGGCGAGGACGCGCGTGCGAAACTCGCGGCGGGCGCGGCGCTCGTCCAGCTG
TACACCGGCTTCATCTATCGGGGCCCGGCGCTCGTCGCCGAATGCGTGAAGGCGATCGCCCGCGGCTAA

Upstream 100 bases:

>100_bases
CCTGGGCCGCTTGCGCCGCCGCGCCGCCCGATCCAGGCTCGCCGGCACTTCTCGGCTAAAATAGCGGGTTGTCAATTTTT
CGGCCGTCGCCGCCTCTGCC

Downstream 100 bases:

>100_bases
GCGCGGTGATATAGAAATAAACAAACGGTATTTAGACATCGATTGTTATTTCGCTATCATTGAGCGATCGATTTCAAGGC
CTCGTCGAAGGCTCCCATCC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNPVGLAAGLDKDGAAIDGFAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPEADAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRH
DIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGGIFSGEDARAKLAAGAALVQL
YTGFIYRGPALVAECVKAIARG

Sequences:

>Translated_342_residues
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNPVGLAAGLDKDGAAIDGFAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPEADAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRH
DIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGGIFSGEDARAKLAAGAALVQL
YTGFIYRGPALVAECVKAIARG
>Mature_342_residues
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNPVGLAAGLDKDGAAIDGFAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPEADAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRH
DIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGGIFSGEDARAKLAAGAALVQL
YTGFIYRGPALVAECVKAIARG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=337, Percent_Identity=43.620178041543, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=55.688622754491, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=41.4110429447853, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=44.9324324324324, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=44.9324324324324, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36323; Mature: 36323

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCCCC
VGLAAGLDKDGAAIDGFAALGFGFIEVGTVTPRAQPGNPRPRMFRLPEADAIINRMGFNN
CCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCC
SGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
DIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGG
HHCCEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECC
IFSGEDARAKLAAGAALVQLYTGFIYRGPALVAECVKAIARG
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCCCC
VGLAAGLDKDGAAIDGFAALGFGFIEVGTVTPRAQPGNPRPRMFRLPEADAIINRMGFNN
CCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCC
SGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
DIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGG
HHCCEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECC
IFSGEDARAKLAAGAALVQLYTGFIYRGPALVAECVKAIARG
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA