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The map label for this gene is hisS [H]

Identifier: 126453409

GI number: 126453409

Start: 2215435

End: 2216775

Strand: Reverse

Name: hisS [H]

Synonym: BURPS1106A_2227

Alternate gene names: 126453409

Gene position: 2216775-2215435 (Counterclockwise)

Preceding gene: 126452211

Following gene: 126454178

Centisome position: 55.58

GC content: 65.62

Gene sequence:

>1341_bases
ATGACAGAACAAAAGCGAAAGCTCGAGAAGCTGACGGGCGTGAAGGGCATGAACGACATCCTCCCGCAGGATGCCGGCTT
GTGGGAATTCTTCGAGGCGACGGTGAAGTCGCTGCTGCGCGCATACGGCTATCAGAACATCCGCACGCCGATCGTCGAGC
ATACGCAGCTCTTCACGCGCGGCATCGGCGAGGTGACCGACATCGTCGAAAAGGAGATGTACAGCTTCGTCGATGCGTTG
AACGGCGAGAACCTGACGCTGCGCCCCGAGAACACCGCGGCCGTCGTGCGCGCGGCGATCGAGCACAACATGCTGTATGA
CGGCCCGAAACGCCTGTGGTATCTCGGGCCGATGTTCCGCCACGAGCGCCCGCAGCGCGGCCGTTATCGCCAGTTCCATC
AGGTCGGCGTCGAGGCGCTCGGCTTCGCGGGCCCCGACGCGGACGCGGAAATCATCATGATGTGCCAGCGCCTGTGGGAC
GATCTCGGTCTCACCGGCATCAAGCTCGAGATCAACTCGCTCGGTCTCGCCGAGGAGCGCGCCGCGCACCGCGTCGAGCT
CATCAAGTATCTCGAGCAGCACGTCGACAAGCTCGACGACGACGCGCAGCGCCGCCTCTACACCAACCCGCTGCGCGTGC
TCGACACGAAGAACCCGGCGCTGCAGGAGATCGTGCGGAACGCGCCGCAGCTGATCGATTTCCTCGGCGACGTGTCGCGC
GCGCACTTCGACGGCCTGCAGCGGCTGCTGAAGGCGAACAACCTGCCGTTTACGATCAATCCGCGGCTCGTGCGCGGGCT
CGACTACTACAACCTGACCGTGTTCGAGTGGGTGACCGACAAGCTCGGCGCGCAGGGCACGGTCGCCGCGGGCGGCCGCT
ACGATCCGCTGATCGAGCAGTTGGGCGGCAAGCCGACCGCCGCGTGCGGCTGGGCGATGGGTGTCGAGCGCATCCTCGAG
CTCCTGAAGGAAGAGCACCTCGTGCCGGAGCAGGAAGGCGTCGACGTGTACGTCGTCCACCAGGGCGACGCGGCGCGCGA
GCAGGCGTTCATCGTCGCCGAGCGTCTGCGCGACACCGGCCTCGACGTGATCCTGCATTGCAGCGCGGACGGCGCGGGCG
CGAGCTTCAAGTCGCAGATGAAGCGCGCGGATGCAAGCGGCGCGGCGTTCGCGGTGATCTTCGGCGAAGACGAGGTCGCG
AACGGCACGGTGAGCGTGAAGCCGCTGCGCGGCACGGGCGCCGAAGGCGAGAAGAACGTTCAGCAGTCCGTGCCGGTCGA
AAGCTTGACCGAATTTCTAATCAATGCGATGGTTGCAACCGCCGAAGACGGCGACGACTGA

Upstream 100 bases:

>100_bases
CGAGCACATCGCGGAAGAGTTCCAGCAGATCGTGAGCGACTACGTCGCGCGCACCTACGGCCGCGCCGCGGCGCAGAATT
AATTCGTCCACCGTATTCAG

Downstream 100 bases:

>100_bases
GCGCCGCGCATCCGCTCGACAAAAAGCGTGTACAGGAAGGAATCGCCAGGCGATGAGTTATCACGACGAACAAGAATCGA
TTGAAAGCCTGAAGGCGTGG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDAL
NGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWD
DLGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSR
AHFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILE
LLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVA
NGTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD

Sequences:

>Translated_446_residues
MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDAL
NGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWD
DLGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSR
AHFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILE
LLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVA
NGTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD
>Mature_445_residues
TEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDALN
GENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDD
LGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSRA
HFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILEL
LKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVAN
GTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=406, Percent_Identity=55.1724137931034, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 49629; Mature: 49498

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTR
CCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFR
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHH
HERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEER
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSR
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHH
AHFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQ
HHHHHHHHHHHHCCCCEEECHHHHHCCCCCCHHHHHHHHHHHCCCCEECCCCCCCHHHHH
LGGKPTAACGWAMGVERILELLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTG
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
LDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVANGTVSVKPLRGTGAEGEKNV
CEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCHHH
QQSVPVESLTEFLINAMVATAEDGDD
HHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTR
CHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFR
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHH
HERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEER
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSR
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHH
AHFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQ
HHHHHHHHHHHHCCCCEEECHHHHHCCCCCCHHHHHHHHHHHCCCCEECCCCCCCHHHHH
LGGKPTAACGWAMGVERILELLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTG
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
LDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVANGTVSVKPLRGTGAEGEKNV
CEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCHHH
QQSVPVESLTEFLINAMVATAEDGDD
HHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA