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The map label for this gene is hisD

Identifier: 126453408

GI number: 126453408

Start: 3636196

End: 3637533

Strand: Reverse

Name: hisD

Synonym: BURPS1106A_3724

Alternate gene names: 126453408

Gene position: 3637533-3636196 (Counterclockwise)

Preceding gene: 126453353

Following gene: 126452351

Centisome position: 91.2

GC content: 69.58

Gene sequence:

>1338_bases
ATGGCTATCAAGATACGCAAACTCGATTCGGCAGGCGAAGGCTTCGCGGCCGAATTGCGCGCGGTGCTCGCGTTCGAGGC
GAGCGAAGACGACGCGATCGAGCGCGCGGTCGCGCAGATTCTCGCCGACGTGAAGGCGCGCGGCGACGCCGCGGTGCTCG
ACTACACGAATCGCTTCGACCGGCTGAACGCGGCGAGCGTCGCGGCGCTCGAGCTGCCGCAAAGCGAGCTGGAAGCGGCG
CTCGAGGGCCTCGAGCCGAAGCGCCGCGCGGCGCTCGAAGCGGCGGCCGCGCGCGTGCGCGGCTACCACGAGAAGCAGAA
GATCGAATGCGGCAGCCATAGCTGGCAGTACACCGAGGCCGACGGCACCGTGCTCGGCCAGAAGGTGACGCCGCTCGACC
GCGTCGGCCTGTACGTGCCGGGCGGCAAGGCCGCGTATCCGTCGTCGGTGCTGATGAACGCGATTCCGGCGCGCGTCGCG
GGCGTCGGCGAGATCGTGATGGTCGTGCCGACGCCGGACGGCCTGAAGAACGATCTCGTGCTCGCCGCGGCGCTGTTGGG
CGGCGTCGATCGCGTGTTCACGATCGGCGGCGCGCAGGCGGTGGCCGCGCTCGCGTACGGCACGCAAACGGTGCCCGCCG
TCGACAAGATCTGCGGGCCGGGCAACGCGTACGTCGCGTCGGCCAAGCGCCGCGTGTTCGGCACGGTCGGCATCGACATG
ATCGCCGGGCCGTCGGAGATCCTCGTGCTGTGCGACGGCACGACCGATCCGTCGTGGGTCGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAGCTCGCGCAATCGATCCTGCTGTGCCCGGACGAAGCGTTCATCGAGCGCGTCGAGAAGGCGATCG
GCGAGCTGCTGCCGACGATGCCGCGCCAGGACGTGATCCGCGCGTCGCTCGAGGGGCGCGGCGCGCTCGTCAAGGTGCGC
GACATGGCCGAGGCGTGCAGGATCGCGAACGACATCGCGCCCGAGCACCTGGAGATCTCCGCGCTCGAGCCGCACCAATG
GGGCAAGCAGATCCGCCACGCGGGCGCGATCTTCCTCGGCCGCTACACGAGCGAGAGCCTGGGCGATTACTGCGCGGGCC
CGAATCACGTGCTGCCGACGTCGCGCACCGCGCGCTTTTCGTCGCCGCTCGGCGTGTACGATTTCTTCAAGCGCTCGAGC
CTGATCGAGGTGAGCGCCGAAGGCGCGCACACGCTCGGCGAGATCGCGTCCGAGCTCGCGTACGGCGAAGGTTTGCAGGC
GCACGCGAAGAGCGCCGAGTACCGGATGAAAGGAGCGGGCGACCGCCAGAAAGGCTAA

Upstream 100 bases:

>100_bases
CCGCGCTGAAGCCGTTCCTCGACGCGTTCGAACGCGCGTCGCTGGGGAGCGGCGCCTGACCCTCCGCGGCTCTCGGCGCA
TTACCGGAACGGATGACAGC

Downstream 100 bases:

>100_bases
GGGTAAGCCCAGCCGCGCCGGTTGCGCGAGACGAGACCAGCCCAAAAAGACGATAACCCGAGACCGCCCGGCGAGGCGTC
TCGCGCGGCGCGACCGGTGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MAIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAA
LEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGLKNDLVLAAALLGGVDRVFTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVR
DMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
LIEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG

Sequences:

>Translated_445_residues
MAIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAA
LEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGLKNDLVLAAALLGGVDRVFTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVR
DMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
LIEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG
>Mature_444_residues
AIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAAL
EGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAG
VGEIVMVVPTPDGLKNDLVLAAALLGGVDRVFTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVRD
MAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSL
IEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=41.4457831325301, Blast_Score=283, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=35.9712230215827, Blast_Score=236, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_BURMA (Q62GD9)

Other databases:

- EMBL:   CP000010
- RefSeq:   YP_104235.1
- ProteinModelPortal:   Q62GD9
- SMR:   Q62GD9
- GeneID:   3091284
- GenomeReviews:   CP000010_GR
- KEGG:   bma:BMA2714
- TIGR:   BMA2714
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q62GD9
- ProtClustDB:   PRK00877
- BioCyc:   BMAL243160:BMA_2714-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47303; Mature: 47172

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 335-335 ACT_SITE 336-336 BINDING 138-138 BINDING 199-199 BINDING 222-222 BINDING 245-245 BINDING 267-267 BINDING 270-270 BINDING 336-336 BINDING 369-369 BINDING 423-423 BINDING 428-428

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFD
CEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHC
RLNAASVAALELPQSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEA
CCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGLKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
LAAALLGGVDRVFTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PRQDVIRASLEGRGALVKVRDMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAHTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEYRMKGAGDRQKG
HCCCHHHHHCCCCEEECCCCCCCCC
>Mature Secondary Structure 
AIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFD
EEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHC
RLNAASVAALELPQSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEA
CCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGLKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
LAAALLGGVDRVFTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PRQDVIRASLEGRGALVKVRDMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAHTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEYRMKGAGDRQKG
HCCCHHHHHCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA