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The map label for this gene is fghA [C]

Identifier: 126453351

GI number: 126453351

Start: 851039

End: 851899

Strand: Direct

Name: fghA [C]

Synonym: BURPS1106A_0867

Alternate gene names: 126453351

Gene position: 851039-851899 (Clockwise)

Preceding gene: 126451444

Following gene: 126453608

Centisome position: 21.34

GC content: 69.69

Gene sequence:

>861_bases
ATGGAAACGACGACGCTCGAATGCGTTTCTTCGCATGCGTGCCACGGCGGCGAGCAGCGCTTCTATCGGCATGAATCGAA
AACGATCGGACTGCCGATGAAATTCTCGGCGTATCTGCCGCCGCAGGCGGCGCACGGCCGCGTGCCGGCGCTGTTCTATC
TCGCCGGGCTCACGTGCACCGAGGAGACGTTCGCGATCAAGGCGGGTGCGCAGCGCTTCGCCGCGCAGCACGGCATCGCG
CTCGTCGCGCCCGATACGAGCCCGCGCGGCGCAGGCGTGCCGGGCGAGGCGGATGCGTGGGATTTCGGCGTCGGCGCGGG
TTTTTACGTCGACGCCACGGAGGCGCCGTGGTCCGCGCATTACCGGATGGAATCGTACGTGAGCGGGGAACTGCGCGAGA
TCGTGGCGGCGGAGCTGCCGATCGATGCCGCGCGGCTCGGCATCTTCGGCCACTCGATGGGCGGCCACGGCGCGCTCGTG
CTCGCGCTGCGCCATCCGCAGCTGTACCGCTCGGTGTCGGCGTTCGCGCCGATCGCCGCGCCGACGCGTTGCCCGTGGGG
CGAGAAGGCGTTTTCCGGCTATCTCGGCGCCGATCGCGAAGCGTGGAAGCGGCACGACGCGAGCGAGCTCGTCGCGCGTG
CCGACGCGAAGCGGTTCGCCGAAGGCATCCTGATCGATCAGGGGCTCGCGGACCCGTTCCTGCCGACGCAGCTCCACCCC
GATGCGTTCGAGGCCGCGTGCCGCGCGGCGGGCCAGCCGCTCACGCTGCGCCGCCACGCCGGCTACGATCACGGCTACTA
CTTCATCTCGACGTTCATCGCCGATCACCTCGCGCATCATGCGCGCGTGCTCGGCCGATGA

Upstream 100 bases:

>100_bases
ACGCACACGCTGCCGCTCGAGAAGATCAACGAAGGCTTCGAGCTGATGAAGAAGGGCGAATCGATCCGCTCGGTCGTGCT
GTACTGATCGGGAGCCTTGC

Downstream 100 bases:

>100_bases
GCCGGCGCGCGAGCGATCGATGAAGCGGTGCGCGACGCGGCGACGCACGCGGCGCGCATGACGAAAAGCCCGCACGGCTC
GAGAGAGCGGTGCGGGCTTT

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
METTTLECVSSHACHGGEQRFYRHESKTIGLPMKFSAYLPPQAAHGRVPALFYLAGLTCTEETFAIKAGAQRFAAQHGIA
LVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWSAHYRMESYVSGELREIVAAELPIDAARLGIFGHSMGGHGALV
LALRHPQLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKRHDASELVARADAKRFAEGILIDQGLADPFLPTQLHP
DAFEAACRAAGQPLTLRRHAGYDHGYYFISTFIADHLAHHARVLGR

Sequences:

>Translated_286_residues
METTTLECVSSHACHGGEQRFYRHESKTIGLPMKFSAYLPPQAAHGRVPALFYLAGLTCTEETFAIKAGAQRFAAQHGIA
LVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWSAHYRMESYVSGELREIVAAELPIDAARLGIFGHSMGGHGALV
LALRHPQLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKRHDASELVARADAKRFAEGILIDQGLADPFLPTQLHP
DAFEAACRAAGQPLTLRRHAGYDHGYYFISTFIADHLAHHARVLGR
>Mature_286_residues
METTTLECVSSHACHGGEQRFYRHESKTIGLPMKFSAYLPPQAAHGRVPALFYLAGLTCTEETFAIKAGAQRFAAQHGIA
LVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWSAHYRMESYVSGELREIVAAELPIDAARLGIFGHSMGGHGALV
LALRHPQLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKRHDASELVARADAKRFAEGILIDQGLADPFLPTQLHP
DAFEAACRAAGQPLTLRRHAGYDHGYYFISTFIADHLAHHARVLGR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=54.0925266903915, Blast_Score=332, Evalue=3e-91,
Organism=Escherichia coli, GI1786551, Length=280, Percent_Identity=47.5, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=50.5376344086022, Blast_Score=271, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=48.3985765124555, Blast_Score=276, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6322393, Length=299, Percent_Identity=37.4581939799331, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45551932, Length=286, Percent_Identity=52.4475524475524, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=52.6501766784452, Blast_Score=302, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30953; Mature: 30953

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTTLECVSSHACHGGEQRFYRHESKTIGLPMKFSAYLPPQAAHGRVPALFYLAGLTCT
CCCCHHHHHHHHCCCCCHHHHHHHCCCEECCCEEECCCCCCCCCCCCCCHHHHHHCCCCC
EETFAIKAGAQRFAAQHGIALVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWSAH
CHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHH
YRMESYVSGELREIVAAELPIDAARLGIFGHSMGGHGALVLALRHPQLYRSVSAFAPIAA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCEEEEEEECHHHHHHHHHHCCCCC
PTRCPWGEKAFSGYLGADREAWKRHDASELVARADAKRFAEGILIDQGLADPFLPTQLHP
CCCCCCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
DAFEAACRAAGQPLTLRRHAGYDHGYYFISTFIADHLAHHARVLGR
HHHHHHHHHCCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METTTLECVSSHACHGGEQRFYRHESKTIGLPMKFSAYLPPQAAHGRVPALFYLAGLTCT
CCCCHHHHHHHHCCCCCHHHHHHHCCCEECCCEEECCCCCCCCCCCCCCHHHHHHCCCCC
EETFAIKAGAQRFAAQHGIALVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWSAH
CHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHH
YRMESYVSGELREIVAAELPIDAARLGIFGHSMGGHGALVLALRHPQLYRSVSAFAPIAA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCEEEEEEECHHHHHHHHHHCCCCC
PTRCPWGEKAFSGYLGADREAWKRHDASELVARADAKRFAEGILIDQGLADPFLPTQLHP
CCCCCCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
DAFEAACRAAGQPLTLRRHAGYDHGYYFISTFIADHLAHHARVLGR
HHHHHHHHHCCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]