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The map label for this gene is nuoD [H]

Identifier: 126453345

GI number: 126453345

Start: 1272527

End: 1273780

Strand: Direct

Name: nuoD [H]

Synonym: BURPS1106A_1302

Alternate gene names: 126453345

Gene position: 1272527-1273780 (Clockwise)

Preceding gene: 126454408

Following gene: 126454652

Centisome position: 31.91

GC content: 62.84

Gene sequence:

>1254_bases
ATGGCTGAAATCAAGAACTACACGCTCAACTTCGGTCCGCAGCACCCGGCCGCGCACGGCGTGCTGCGCCTCGTGCTCGA
GCTCGACGGCGAAGTGATCCAGCGCGCCGATCCGCACATCGGCCTGCTGCACCGGGCAACCGAGAAGCTCGCCGAGAACA
AGACGTTCATCCAGTCCGTGCCGTACATGGACCGTCTCGACTACGTGTCGATGATGGTGAACGAACACGGTTACGTGCTC
GCGATCGAGAAGCTGCTCGGCATCGAGGTGCCGGAACGCGCGCAATACATCCGCGTGCTGTTCGACGAAATCACGCGCGT
GCTGAACCACCTGATGTGGATCGGCGCGCACGCGCTCGACGTCGGCGCGATGGCGGTGTTCCTGTATGCGTTCCGCGAGC
GCGAGGACCTGATGGACGTGTACGAGGCGGTGTCCGGCGCGCGCATGCACGCGGCGTACTATCGTCCGGGCGGCGTCTAT
CGCGATCTGCCGGAAGCCATGCCGCAGTACAAGGCGTCGAAGATTCGCAACGAACGTGCGCTCGCGAAGATGAACGAGGC
GCGCTCGGGTTCGGTGCTCGATTTCATCGACGATTTCTTCACGCGCTTTCCGAAGTGCGTCGACGAATACGAAACGCTGC
TGACCGACAACCGGATCTGGAAGCAGCGTCTCGTGGGCATCGGCGTCGTGTCGCCGGAGCGCGCGCTGCAGCTCGGCCTG
ACGGGGCCGATGATCCGCGGCTCCGGTATCGCATGGGATCTGCGCAAGAAGCAGCCGTACGAAGTGTACGACCGCCTCGA
CTTCGATATCCCCGTCGGCGTGAACGGCGATTGCTACGACCGCTATCTGGTGCGCGTCGAGGAGATGCGCCAGTCGACGC
GTATCGCGAAACAATGTATTGAGTGGCTTCGCAAGAATCCCGGCCCCGTGATCACCGACAATCACAAGGTCGCGCCGCCG
TCGCGTGTCGGCATGAAGACGAACATGGAGGATCTGATCCACCATTTCAAGCTCTTCACCGAAGGTTTTCACGTGCCCGA
GGGCGAGACGTACGCCGCCGTCGAGCATCCGAAGGGCGAATTCGGCATCTATCTGGTGTCGGACGGCGCGAACAAGCCGT
ACCGGCTCAAGATTCGCGCGCCGGGCTACGCCCATCTGTCCGCGCTCGACGAAATGGCGCGCGGGCACATGATCGCCGAC
GCCGTCACGATCATCGGGACGCAGGACATCGTGTTCGGCGAAATCGACCGCTGA

Upstream 100 bases:

>100_bases
CGCGTCGTGTACCAGCCGGTGACGATCGAGCCGCGCGAAATCACGCCGCGCGTGATCCGCGAGGATCGCTATGGCGGTCT
GAAACATTAAGGGTGGCGTC

Downstream 100 bases:

>100_bases
CGGTCGCGCCGCCCGCCGGCCCGAGCCGGGCGGCAGGCGGCGAGTCACACGCGGCGCGCATTCGGGTGCGCCGTCGCAAC
AAGCTGTCAACAGTGAGCGC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAENKTFIQSVPYMDRLDYVSMMVNEHGYVL
AIEKLLGIEVPERAQYIRVLFDEITRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVY
RDLPEAMPQYKASKIRNERALAKMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQLGL
TGPMIRGSGIAWDLRKKQPYEVYDRLDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCIEWLRKNPGPVITDNHKVAPP
SRVGMKTNMEDLIHHFKLFTEGFHVPEGETYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIAD
AVTIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAENKTFIQSVPYMDRLDYVSMMVNEHGYVL
AIEKLLGIEVPERAQYIRVLFDEITRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVY
RDLPEAMPQYKASKIRNERALAKMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQLGL
TGPMIRGSGIAWDLRKKQPYEVYDRLDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCIEWLRKNPGPVITDNHKVAPP
SRVGMKTNMEDLIHHFKLFTEGFHVPEGETYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIAD
AVTIIGTQDIVFGEIDR
>Mature_416_residues
AEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAENKTFIQSVPYMDRLDYVSMMVNEHGYVLA
IEKLLGIEVPERAQYIRVLFDEITRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYR
DLPEAMPQYKASKIRNERALAKMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQLGLT
GPMIRGSGIAWDLRKKQPYEVYDRLDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCIEWLRKNPGPVITDNHKVAPPS
RVGMKTNMEDLIHHFKLFTEGFHVPEGETYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIADA
VTIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=60.8695652173913, Blast_Score=517, Evalue=1e-147,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.0490196078431, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.0487804878049, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1789076, Length=419, Percent_Identity=28.4009546539379, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.4509803921569, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=58.7951807228916, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=57.5903614457831, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=60.2409638554217, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221459469, Length=412, Percent_Identity=55.0970873786408, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47507; Mature: 47376

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAENKTFIQSV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHC
PYMDRLDYVSMMVNEHGYVLAIEKLLGIEVPERAQYIRVLFDEITRVLNHLMWIGAHALD
CCHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPEAMPQYKASKIRNERA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LAKMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQLGL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHEECC
TGPMIRGSGIAWDLRKKQPYEVYDRLDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCI
CCCCEECCCCEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVITDNHKVAPPSRVGMKTNMEDLIHHFKLFTEGFHVPEGETYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure 
AEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAENKTFIQSV
CCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHC
PYMDRLDYVSMMVNEHGYVLAIEKLLGIEVPERAQYIRVLFDEITRVLNHLMWIGAHALD
CCHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPEAMPQYKASKIRNERA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LAKMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQLGL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHEECC
TGPMIRGSGIAWDLRKKQPYEVYDRLDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCI
CCCCEECCCCEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVITDNHKVAPPSRVGMKTNMEDLIHHFKLFTEGFHVPEGETYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA