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The map label for this gene is nuoE [H]

Identifier: 126454652

GI number: 126454652

Start: 1273949

End: 1274434

Strand: Direct

Name: nuoE [H]

Synonym: BURPS1106A_1303

Alternate gene names: 126454652

Gene position: 1273949-1274434 (Clockwise)

Preceding gene: 126453345

Following gene: 126454273

Centisome position: 31.94

GC content: 60.7

Gene sequence:

>486_bases
ATGATCTCAGCTGAAGGCCTGAAAGAAATCGATCGAGCGATCGCGAAGTATCCCGCCGATCAGAAACAGTCCGCTGTGAT
GTCGGCGCTGGCCGTCGCTCAGGAAGAGCATGGCTGGCTGTCGCCCGAACTGATGCAGTTCGTCGCGGACTATCTCGGCA
TGCCGGCCATCGCGGTCCAGGAAGTCGCGACGTTCTACACGATGTACGAGCTCGCGCCTGTCGGCAAGCACAAGATCACG
CTCTGCACGAACCTGCCGTGCCAGCTCGGCCCGCACGGCGGCGCCGAGGCGACGGCCGACTATCTGAAGCAAAAGCTCGG
CATCGATTTCGGCGAAACCACGCCGGACGGCAAGTTCACGCTGAAGGAAGGCGAATGCTTCGGCGCGTGCGGCGATGCGC
CGGTGCTGCTGCTCAACAATCACAAAATGTGCAGCTTCATGAGCCGCGAGAAGATCGACCAGCTGCTTGAGGAGCTCTCG
AAATGA

Upstream 100 bases:

>100_bases
CGCCGTCGCAACAAGCTGTCAACAGTGAGCGCCAGGTCTGCCGCATCGATCATGCGGCAGGTTGTTCGTGCGGTAGGAAT
TGAAAGAGTCGTGTCTGAAA

Downstream 100 bases:

>100_bases
CGTCCCTTCACGATCGTCACATCAAACCGCTGATCCTCGCCGGCCTGACCGGCGAGAACTGGCATCTCGAAGACTACGTC
GCGCGCGGCGGCTACAAGCA

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I chain 2; NDH-1 subunit 2 [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MISAEGLKEIDRAIAKYPADQKQSAVMSALAVAQEEHGWLSPELMQFVADYLGMPAIAVQEVATFYTMYELAPVGKHKIT
LCTNLPCQLGPHGGAEATADYLKQKLGIDFGETTPDGKFTLKEGECFGACGDAPVLLLNNHKMCSFMSREKIDQLLEELS
K

Sequences:

>Translated_161_residues
MISAEGLKEIDRAIAKYPADQKQSAVMSALAVAQEEHGWLSPELMQFVADYLGMPAIAVQEVATFYTMYELAPVGKHKIT
LCTNLPCQLGPHGGAEATADYLKQKLGIDFGETTPDGKFTLKEGECFGACGDAPVLLLNNHKMCSFMSREKIDQLLEELS
K
>Mature_161_residues
MISAEGLKEIDRAIAKYPADQKQSAVMSALAVAQEEHGWLSPELMQFVADYLGMPAIAVQEVATFYTMYELAPVGKHKIT
LCTNLPCQLGPHGGAEATADYLKQKLGIDFGETTPDGKFTLKEGECFGACGDAPVLLLNNHKMCSFMSREKIDQLLEELS
K

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=158, Percent_Identity=40.5063291139241, Blast_Score=127, Evalue=6e-30,
Organism=Escherichia coli, GI1788621, Length=157, Percent_Identity=33.1210191082803, Blast_Score=90, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17561328, Length=158, Percent_Identity=38.6075949367089, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI18859877, Length=154, Percent_Identity=38.961038961039, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21355353, Length=139, Percent_Identity=38.1294964028777, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 17571; Mature: 17571

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAEGLKEIDRAIAKYPADQKQSAVMSALAVAQEEHGWLSPELMQFVADYLGMPAIAVQ
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
EVATFYTMYELAPVGKHKITLCTNLPCQLGPHGGAEATADYLKQKLGIDFGETTPDGKFT
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEE
LKEGECFGACGDAPVLLLNNHKMCSFMSREKIDQLLEELSK
EECCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISAEGLKEIDRAIAKYPADQKQSAVMSALAVAQEEHGWLSPELMQFVADYLGMPAIAVQ
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
EVATFYTMYELAPVGKHKITLCTNLPCQLGPHGGAEATADYLKQKLGIDFGETTPDGKFT
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEE
LKEGECFGACGDAPVLLLNNHKMCSFMSREKIDQLLEELSK
EECCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134 [H]