Click here to switch to the map view.

The map label for this gene is pheP [H]

Identifier: 126453093

GI number: 126453093

Start: 946745

End: 948121

Strand: Direct

Name: pheP [H]

Synonym: BURPS1106A_0965

Alternate gene names: 126453093

Gene position: 946745-948121 (Clockwise)

Preceding gene: 126452761

Following gene: 126453919

Centisome position: 23.74

GC content: 66.74

Gene sequence:

>1377_bases
TTGACACAACAACAACGGACGTTCGACTCGATCGTCGAACGCGAGAAGGGCCTGCGGCGCGGGCTCTCGTCGGCTCAGAT
GGCGATGATCGCGATCGGCGGCGCGATCGGCACGGGGCTGTTTCTCGGCAGCGGTTTCGCGATCGGGCTCGCCGGGCCGG
GCGTGCTGGTGTCGTATGCGATCGGTGCGCTGATCGCGTTGCTGCTGATGGGCGCGCTCGCCGAGATGACGGTCGCGCAT
CCGACCTCCGGCTCGTTCGGCGCGTATGCCGAGCACTACGTCGGCCCGCTCGCGGGCTTTCTCGTCCGCTATGCGTACTG
GTCGGCCGTGGTGTTCGCGGTCGGCACCGAGGTGAGCGCGATCGCCGTCTTCATGAAGTACTGGTATCCGGGCGTGCCCG
GCTGGTATTGGGTCGTCGGCTTCTCGGCCGTGCTGATCGCGGTGAACATGACGAGCGTCACGCTTTACGGCGTCGTCGAA
TACGTGTTCTCGATGCTGAAGATCGCCGCGATCGTCGCGTTCATCGCGCTTGGCGCGTACTTCGTCGCGGCGGCGCCCGC
GTCGTCCGGCATCGGCTTCGCGAACTATTCGGCGCACGGCGGCTTCTTTCCAAAAGGCTTCTCGGGCGTGTGGGTCGCGG
TGATTGTCGCGATTTTCAGCTATATGAGCATCGAAACCGTCGCGATCGCGGCGGGCGAGGCGCGCGATCCGCAGCGCGCG
GTGTCGCGCGCGTTTCGGTCGACCGTGTTTCGTCTCGTGCTGTTCTATCTGCTCACGCTCGCGCTGATGCTCGCGATCGT
GCCGTGGACGCAGGCGGGCACCGACGAGAGCCCGTTCGTCAAGGTGATGGCCGCGACGCACGTGCCGTATGCGGCGGGCG
TCATCAATTTCGTCGTGCTCGTCGCCGCGCTGTCGGCGATGAACAGCCAGCTATATGTGACGACGCGGATGATGTTCAGC
CTCTCCCGCGCGCGGCTCGCGCCCGCGATGTTCGGGCGCGTCGGCGCGAACGGCGTGCCGCTCGCGGCGCTCGCCGTGTC
GTCGAGCGGCGTCGCGGTCGCGGCCGTGCTGGTTGCGCTGTATCCGCAGACCGCGTTCACGCTGCTGATGGCGATCGCGA
TGTTCGGCGCGCTGTTCACGTGGCTGATGATTTTCGTCACGCATCTGCGCTTTCGGGCGCGCTATCGCGGCCCCACGCCC
GTGTTTCGGATGTGGCTGCATCCGGCGGGCAGCCTGACGGGCGCGGCGCTCGTCGGCGCGGTGCTCGTGACGACCGCGTT
TACGCGCGAGTTCAGAATGACGATGATGGTCGGCGTGGCGTTCATCGTGCTGCTGACGCTCGCCTATCGATGGCATTACC
GCGCGCGGCACGCGTGA

Upstream 100 bases:

>100_bases
GTTGTAGGTCCGAAACGTTTCGCATGAACGGCGCGGGAAGTCTTCCGCGCCGTTTCGTTTTATTTGCGGCAGATGAAAGG
TACGGAAGCAGGAGTCTGGT

Downstream 100 bases:

>100_bases
GCGGCACGGCCCGGCGCTGCGCGAACCGGCGATGGCGCGGCGAGCAGGGCGGCACATCCGATGAGGAGCGGCATGACGAC
GATCAAGGCAGGCGACGCAT

Product: amino acid permease

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTQQQRTFDSIVEREKGLRRGLSSAQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAH
PTSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAVLIAVNMTSVTLYGVVE
YVFSMLKIAAIVAFIALGAYFVAAAPASSGIGFANYSAHGGFFPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRA
VSRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFS
LSRARLAPAMFGRVGANGVPLAALAVSSSGVAVAAVLVALYPQTAFTLLMAIAMFGALFTWLMIFVTHLRFRARYRGPTP
VFRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFIVLLTLAYRWHYRARHA

Sequences:

>Translated_458_residues
MTQQQRTFDSIVEREKGLRRGLSSAQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAH
PTSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAVLIAVNMTSVTLYGVVE
YVFSMLKIAAIVAFIALGAYFVAAAPASSGIGFANYSAHGGFFPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRA
VSRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFS
LSRARLAPAMFGRVGANGVPLAALAVSSSGVAVAAVLVALYPQTAFTLLMAIAMFGALFTWLMIFVTHLRFRARYRGPTP
VFRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFIVLLTLAYRWHYRARHA
>Mature_457_residues
TQQQRTFDSIVEREKGLRRGLSSAQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAHP
TSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAVLIAVNMTSVTLYGVVEY
VFSMLKIAAIVAFIALGAYFVAAAPASSGIGFANYSAHGGFFPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRAV
SRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFSL
SRARLAPAMFGRVGANGVPLAALAVSSSGVAVAAVLVALYPQTAFTLLMAIAMFGALFTWLMIFVTHLRFRARYRGPTPV
FRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFIVLLTLAYRWHYRARHA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=320, Percent_Identity=25.625, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=38.0630630630631, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1786302, Length=448, Percent_Identity=34.1517857142857, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI87081708, Length=454, Percent_Identity=36.5638766519824, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI48994972, Length=452, Percent_Identity=34.070796460177, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=34.070796460177, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1790653, Length=465, Percent_Identity=30.9677419354839, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789017, Length=441, Percent_Identity=33.7868480725624, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI87081915, Length=383, Percent_Identity=33.9425587467363, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1788480, Length=402, Percent_Identity=34.5771144278607, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87081869, Length=246, Percent_Identity=25.2032520325203, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324553, Length=402, Percent_Identity=32.3383084577114, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=437, Percent_Identity=30.6636155606407, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320772, Length=455, Percent_Identity=29.010989010989, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=456, Percent_Identity=28.2894736842105, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324059, Length=419, Percent_Identity=32.2195704057279, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=401, Percent_Identity=31.4214463840399, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=28.9672544080605, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=412, Percent_Identity=30.0970873786408, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=409, Percent_Identity=29.3398533007335, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=27.1604938271605, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=28.1094527363184, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=395, Percent_Identity=27.5949367088608, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=27.5689223057644, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=389, Percent_Identity=26.7352185089974, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=419, Percent_Identity=27.4463007159904, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=451, Percent_Identity=25.4988913525499, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.5353535353535, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=458, Percent_Identity=22.9257641921397, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667468, Length=429, Percent_Identity=22.3776223776224, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48912; Mature: 48780

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQQQRTFDSIVEREKGLRRGLSSAQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]